Sugi Variant

Sugi Variant/GHR

GHR — 607 ClinVar variants

All ClinVar germline GHR variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 231 flagged for review →

46 Pathogenic · 7 Pathogenic/Likely pathogenic · 10 Likely pathogenic · 38 Conflicting · 36 Benign · 11 Benign/Likely benign · 190 Likely benign · 269 Uncertain significance

Full GHR gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions

⚑ Evidence disagreements 231

Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.

Predictors vs ClinVar 1

ClinVar calls these pathogenic, but the computational predictors lean tolerated — the highest-value review flag.

Predictors agree, ClinVar conflicts 16

ClinVar submitters conflict, but the independent predictors unanimously agree — a QC review flag, not a reclassification.

Predictors lean, ClinVar uncertain 183

ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification. · showing the 150 best-reviewed of 183

Predictors split 31

The independent predictors disagree with each other — read with care.

All GHR variants

Pathogenic 46

Pathogenic/Likely pathogenic 7

Likely pathogenic 10

Conflicting classifications of pathogenicity 38

Benign 36

Benign/Likely benign 11

Likely benign 190

Uncertain significance 269