GID4 — 25 ClinVar variants
All ClinVar germline GID4 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 23 flagged for review →
1 Likely benign · 24 Uncertain significance
Full GID4 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 23
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 19
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- GID4 p.Ala38Glu Uncertain significance Single submitter
- GID4 p.Arg35Gly Uncertain significance Single submitter
- GID4 p.Arg49Leu Uncertain significance Single submitter
- GID4 p.Arg64Ser Uncertain significance Single submitter
- GID4 p.Asn285Ile Uncertain significance Single submitter
- GID4 p.Gln36Pro Uncertain significance Single submitter
- GID4 p.Glu224Lys Uncertain significance Single submitter
- GID4 p.Glu30Lys Uncertain significance Single submitter
- GID4 p.Gly125Ser Uncertain significance Single submitter
- GID4 p.Leu54Val Uncertain significance Single submitter
- GID4 p.Leu61Arg Uncertain significance Single submitter
- GID4 p.Pro18Ser Uncertain significance Single submitter
- GID4 p.Pro29Ser Uncertain significance Single submitter
- GID4 p.Pro72Ser Uncertain significance Single submitter
- GID4 p.Pro74Ser Uncertain significance Single submitter
- GID4 p.Ser55Tyr Uncertain significance Single submitter
- GID4 p.Thr150Met Uncertain significance Single submitter
- GID4 p.Val143Met Uncertain significance Single submitter
- GID4 p.Val22Phe Uncertain significance Single submitter
Predictors split 4
The independent predictors disagree with each other — read with care.
All GID4 variants
Likely benign 1
- p.Ser217= Single submitter
Uncertain significance 24
- p.Ala118Asp Single submitter ⚠
- p.Ala38Glu Single submitter ⚠
- p.Arg35Gly Single submitter ⚠
- p.Arg49Leu Single submitter ⚠
- p.Arg64Ser Single submitter ⚠
- p.Asn285Ile Single submitter ⚠
- p.Gln36Pro Single submitter ⚠
- p.Glu224Lys Single submitter ⚠
- p.Glu30Lys Single submitter ⚠
- p.Gly125Ser Single submitter ⚠
- p.His131Gln Single submitter ⚠
- p.Leu54Val Single submitter ⚠
- p.Leu61Arg Single submitter ⚠
- p.Pro18Ser Single submitter ⚠
- p.Pro29Ser Single submitter ⚠
- p.Pro72Ser Single submitter ⚠
- p.Pro74Ser Single submitter ⚠
- p.Ser120Cys Single submitter ⚠
- p.Ser55Tyr Single submitter ⚠
- p.Thr150Lys Single submitter
- p.Thr150Met Single submitter ⚠
- p.Val143Met Single submitter ⚠
- p.Val22Phe Single submitter ⚠
- p.Val231Leu Single submitter ⚠