GIPR — 47 ClinVar variants
All ClinVar germline GIPR variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 45 flagged for review →
1 Benign · 1 Likely benign · 45 Uncertain significance
Full GIPR gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 45
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 21
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- GIPR p.Ala23Gly Uncertain significance Single submitter
- GIPR p.Arg12Gly Uncertain significance Single submitter
- GIPR p.Arg289Leu Uncertain significance Single submitter
- GIPR p.Arg370Ser Uncertain significance Single submitter
- GIPR p.Arg41Gln Uncertain significance Single submitter
- GIPR p.Asp129Glu Uncertain significance Single submitter
- GIPR p.Asp66Val Uncertain significance Single submitter
- GIPR p.Cys286Arg Uncertain significance Single submitter
- GIPR p.Gly250Ser Uncertain significance Single submitter
- GIPR p.Leu111Val Uncertain significance Single submitter
- GIPR p.Leu132Arg Uncertain significance Single submitter
- GIPR p.Leu241Pro Uncertain significance Single submitter
- GIPR p.Leu318Pro Uncertain significance Single submitter
- GIPR p.Leu446Ser Uncertain significance Single submitter
- GIPR p.Met140Thr Uncertain significance Single submitter
- GIPR p.Met305Val Uncertain significance Single submitter
- GIPR p.Pro348His Uncertain significance Single submitter
- GIPR p.Ser415Gly Uncertain significance Single submitter
- GIPR p.Ser447Thr Uncertain significance Single submitter
- GIPR p.Ser57Pro Uncertain significance Single submitter
- GIPR p.Tyr36Ser Uncertain significance Single submitter
Predictors split 24
The independent predictors disagree with each other — read with care.
- GIPR p.Ala268Glu Uncertain significance Single submitter
- GIPR p.Ala74Gly Uncertain significance Single submitter
- GIPR p.Ala75Val Uncertain significance Single submitter
- GIPR p.Arg300Trp Uncertain significance Single submitter
- GIPR p.Arg331Ser Uncertain significance Single submitter
- GIPR p.Arg341Leu Uncertain significance Single submitter
- GIPR p.Arg404Ser Uncertain significance Single submitter
- GIPR p.Arg411Cys Uncertain significance Single submitter
- GIPR p.Asp106Asn Uncertain significance Single submitter
- GIPR p.Cys16Tyr Uncertain significance Single submitter
- GIPR p.Gln8Glu Uncertain significance Single submitter
- GIPR p.Glu252Lys Uncertain significance Single submitter
- GIPR p.Glu34Gly Uncertain significance Single submitter
- GIPR p.Gly17Arg Uncertain significance Single submitter
- GIPR p.Leu157Ile Uncertain significance Single submitter
- GIPR p.Leu159Phe Uncertain significance Single submitter
- GIPR p.Leu261His Uncertain significance Single submitter
- GIPR p.Leu304Arg Uncertain significance Single submitter
- GIPR p.Leu312Pro Uncertain significance Single submitter
- GIPR p.Ser415Ile Uncertain significance Single submitter
- GIPR p.Ser64Tyr Uncertain significance Single submitter
- GIPR p.Thr25Ile Uncertain significance Single submitter
- GIPR p.Thr31Lys Uncertain significance Single submitter
- GIPR p.Val356Ala Uncertain significance Single submitter
All GIPR variants
Benign 1
- c.280+273A>C Single submitter
Likely benign 1
- p.Gln108= Single submitter
Uncertain significance 45
- p.Ala23Gly Single submitter ⚠
- p.Ala268Glu Single submitter ⚠
- p.Ala74Gly Single submitter ⚠
- p.Ala75Val Single submitter ⚠
- p.Arg12Gly Single submitter ⚠
- p.Arg289Leu Single submitter ⚠
- p.Arg300Trp Single submitter ⚠
- p.Arg331Ser Single submitter ⚠
- p.Arg341Leu Single submitter ⚠
- p.Arg370Ser Single submitter ⚠
- p.Arg404Ser Single submitter ⚠
- p.Arg411Cys Single submitter ⚠
- p.Arg41Gln Single submitter ⚠
- p.Asp106Asn Single submitter ⚠
- p.Asp129Glu Single submitter ⚠
- p.Asp66Val Single submitter ⚠
- p.Cys16Tyr Single submitter ⚠
- p.Cys286Arg Single submitter ⚠
- p.Gln8Glu Single submitter ⚠
- p.Glu252Lys Single submitter ⚠
- p.Glu34Gly Single submitter ⚠
- p.Gly17Arg Single submitter ⚠
- p.Gly250Ser Single submitter ⚠
- p.Leu111Val Single submitter ⚠
- p.Leu132Arg Single submitter ⚠
- p.Leu157Ile Single submitter ⚠
- p.Leu159Phe Single submitter ⚠
- p.Leu241Pro Single submitter ⚠
- p.Leu261His Single submitter ⚠
- p.Leu304Arg Single submitter ⚠
- p.Leu312Pro Single submitter ⚠
- p.Leu318Pro Single submitter ⚠
- p.Leu446Ser Single submitter ⚠
- p.Met140Thr Single submitter ⚠
- p.Met305Val Single submitter ⚠
- p.Pro348His Single submitter ⚠
- p.Ser415Gly Single submitter ⚠
- p.Ser415Ile Single submitter ⚠
- p.Ser447Thr Single submitter ⚠
- p.Ser57Pro Single submitter ⚠
- p.Ser64Tyr Single submitter ⚠
- p.Thr25Ile Single submitter ⚠
- p.Thr31Lys Single submitter ⚠
- p.Tyr36Ser Single submitter ⚠
- p.Val356Ala Single submitter ⚠