GLO1 — 17 ClinVar variants
All ClinVar germline GLO1 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 15 flagged for review →
1 Likely benign · 16 Uncertain significance
Full GLO1 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 15
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 8
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- GLO1 p.Cys61Trp Uncertain significance Single submitter
- GLO1 p.Glu14Asp Uncertain significance Single submitter
- GLO1 p.Glu14Gln Uncertain significance Single submitter
- GLO1 p.Gly10Ser Uncertain significance Single submitter
- GLO1 p.Gly126Ser Uncertain significance Single submitter
- GLO1 p.Phe149Val Uncertain significance Single submitter
- GLO1 p.Val135Gly Uncertain significance Single submitter
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GLO1 p.Glu111Ala
Uncertain significance
No assertion criteria
autism, susceptibility to, 1
Predictors split 7
The independent predictors disagree with each other — read with care.
- GLO1 p.Arg141Lys Uncertain significance Single submitter
- GLO1 p.Glu14Lys Uncertain significance Single submitter
- GLO1 p.Lys28Thr Uncertain significance Single submitter
- GLO1 p.Met158Ile Uncertain significance Single submitter
- GLO1 p.Pro25Arg Uncertain significance Single submitter
- GLO1 p.Thr112Ile Uncertain significance Single submitter
- GLO1 p.Val135Ala Uncertain significance Single submitter
All GLO1 variants
Likely benign 1
- c.377-5G>A Multiple submitters
Uncertain significance 16
- p.Ala162Ser Single submitter
- p.Arg141Lys Single submitter ⚠
- p.Cys61Trp Single submitter ⚠
- p.Glu14Asp Single submitter ⚠
- p.Glu14Gln Single submitter ⚠
- p.Glu14Lys Single submitter ⚠
- p.Gly10Ser Single submitter ⚠
- p.Gly126Ser Single submitter ⚠
- p.Lys28Thr Single submitter ⚠
- p.Met158Ile Single submitter ⚠
- p.Phe149Val Single submitter ⚠
- p.Pro25Arg Single submitter ⚠
- p.Thr112Ile Single submitter ⚠
- p.Val135Ala Single submitter ⚠
- p.Val135Gly Single submitter ⚠
- p.Glu111Ala No assertion criteria autism, susceptibility to, 1 ⚠