GLP1R — 47 ClinVar variants
All ClinVar germline GLP1R variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 33 flagged for review →
8 Benign · 4 Likely benign · 35 Uncertain significance
Full GLP1R gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 33
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 24
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- GLP1R p.Arg9Cys Uncertain significance Single submitter
- GLP1R p.Arg9His Uncertain significance Single submitter
- GLP1R p.Cys46Tyr Uncertain significance Single submitter
- GLP1R p.Gln37Arg Uncertain significance Single submitter
- GLP1R p.Glu41Ala Uncertain significance Single submitter
- GLP1R p.Glu41Asp Uncertain significance Single submitter
- GLP1R p.Gly16Trp Uncertain significance Single submitter
- GLP1R p.Gly75Ala Uncertain significance Single submitter
- GLP1R p.His173Arg Uncertain significance Single submitter
- GLP1R p.His374Gln Uncertain significance Single submitter
- GLP1R p.Ile147Met Uncertain significance Single submitter
- GLP1R p.Ile196Thr Uncertain significance Single submitter
- GLP1R p.Ile272Met Uncertain significance Single submitter
- GLP1R p.Ile286Val Uncertain significance Single submitter
- GLP1R p.Ile330Val Uncertain significance Single submitter
- GLP1R p.Ile427Asn Uncertain significance Single submitter
- GLP1R p.Leu268Phe Uncertain significance Single submitter
- GLP1R p.Met17Thr Uncertain significance Single submitter
- GLP1R p.Met433Ile Uncertain significance Single submitter
- GLP1R p.Pro439Arg Uncertain significance Single submitter
- GLP1R p.Pro5Leu Uncertain significance Single submitter
- GLP1R p.Ser157Phe Uncertain significance Single submitter
- GLP1R p.Tyr269Cys Uncertain significance Single submitter
- GLP1R p.Val83Ile Uncertain significance Single submitter
Predictors split 9
The independent predictors disagree with each other — read with care.
- GLP1R p.Ala11Glu Uncertain significance Single submitter
- GLP1R p.Arg421Trp Uncertain significance Single submitter
- GLP1R p.Arg44Cys Uncertain significance Single submitter
- GLP1R p.Asn320Ser Uncertain significance Single submitter
- GLP1R p.Asp122Tyr Uncertain significance Single submitter
- GLP1R p.Leu244Ile Uncertain significance Single submitter
- GLP1R p.Met303Thr Uncertain significance Single submitter
- GLP1R p.Pro77Leu Uncertain significance Single submitter
- GLP1R p.Val246Met Uncertain significance Single submitter
All GLP1R variants
Benign 8
Likely benign 4
- p.Ala449Val Single submitter
- p.Ile272Val Single submitter
- p.Leu167= Single submitter
- p.Ser258= Single submitter
Uncertain significance 35
- c.402+3del Single submitter type 2 diabetes mellitus
- p.Ala11Glu Single submitter ⚠
- p.Arg421Trp Single submitter ⚠
- p.Arg44Cys Single submitter ⚠
- p.Arg9Cys Single submitter ⚠
- p.Arg9His Single submitter ⚠
- p.Asn320Ser Single submitter ⚠
- p.Asp122Tyr Single submitter ⚠
- p.Cys46Tyr Single submitter ⚠
- p.Gln37Arg Single submitter ⚠
- p.Glu41Ala Single submitter ⚠
- p.Glu41Asp Single submitter ⚠
- p.Gly16Trp Single submitter ⚠
- p.Gly75Ala Single submitter ⚠
- p.His173Arg Single submitter ⚠
- p.His374Gln Single submitter ⚠
- p.Ile147Met Single submitter ⚠
- p.Ile196Thr Single submitter ⚠
- p.Ile272Met Single submitter ⚠
- p.Ile286Val Single submitter ⚠
- p.Ile330Val Single submitter ⚠
- p.Ile427Asn Single submitter ⚠
- p.Leu244Ile Single submitter ⚠
- p.Leu268Phe Single submitter ⚠
- p.Met17Thr Single submitter ⚠
- p.Met303Thr Single submitter ⚠
- p.Met433Ile Single submitter ⚠
- p.Pro439Arg Single submitter ⚠
- p.Pro5Leu Single submitter ⚠
- p.Pro77Leu Single submitter ⚠
- p.Ser157Phe Single submitter ⚠
- p.Tyr269Cys Single submitter ⚠
- p.Val246Met Single submitter ⚠
- p.Val81Met Single submitter
- p.Val83Ile Single submitter ⚠