GLRA3 — 51 ClinVar variants
All ClinVar germline GLRA3 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 48 flagged for review →
1 Benign · 50 Uncertain significance
Full GLRA3 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 48
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 40
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- GLRA3 p.Ala284Ser Uncertain significance Single submitter
- GLRA3 p.Ala2Thr Uncertain significance Single submitter
- GLRA3 p.Ala34Glu Uncertain significance Single submitter
- GLRA3 p.Ala39Pro Uncertain significance Single submitter
- GLRA3 p.Ala434Gly Uncertain significance Single submitter
- GLRA3 p.Arg229Leu Uncertain significance Single submitter
- GLRA3 p.Arg251Gln Uncertain significance Single submitter
- GLRA3 p.Arg251Gly Uncertain significance Single submitter
- GLRA3 p.Arg35Ser Uncertain significance Single submitter
- GLRA3 p.Arg37Gln Uncertain significance Single submitter
- GLRA3 p.Arg424Trp Uncertain significance Single submitter
- GLRA3 p.Arg5Gly Uncertain significance Single submitter
- GLRA3 p.Asn278Thr Uncertain significance Single submitter
- GLRA3 p.Asn404Ser Uncertain significance Single submitter
- GLRA3 p.Asp423Asn Uncertain significance Single submitter
- GLRA3 p.Asp464Gly Uncertain significance Single submitter
- GLRA3 p.Cys435Ser Uncertain significance Single submitter
- GLRA3 p.Cys74Trp Uncertain significance Single submitter
- GLRA3 p.Gln463Pro Uncertain significance Single submitter
- GLRA3 p.Gly402Val Uncertain significance Single submitter
- GLRA3 p.His456Arg Uncertain significance Single submitter
- GLRA3 p.Ile459Met Uncertain significance Single submitter
- GLRA3 p.Leu215Phe Uncertain significance Single submitter
- GLRA3 p.Leu25Met Uncertain significance Single submitter
- GLRA3 p.Lys137Arg Uncertain significance Single submitter
- GLRA3 p.Met187Thr Uncertain significance Single submitter
- GLRA3 p.Met388Lys Uncertain significance Single submitter
- GLRA3 p.Phe383Val Uncertain significance Single submitter
- GLRA3 p.Pro120Ser Uncertain significance Single submitter
- GLRA3 p.Ser191Gly Uncertain significance Single submitter
- GLRA3 p.Thr216Ser Uncertain significance Single submitter
- GLRA3 p.Thr241Ala Uncertain significance Single submitter
- GLRA3 p.Thr28Ile Uncertain significance Single submitter
- GLRA3 p.Thr9Ile Uncertain significance Single submitter
- GLRA3 p.Tyr312Asp Uncertain significance Single submitter
- GLRA3 p.Tyr451Cys Uncertain significance Single submitter
- GLRA3 p.Val209Ile Uncertain significance Single submitter
- GLRA3 p.Val26Phe Uncertain significance Single submitter
- GLRA3 p.Val293Met Uncertain significance Single submitter
- GLRA3 p.Val409Ile Uncertain significance Single submitter
Predictors split 8
The independent predictors disagree with each other — read with care.
- GLRA3 p.Asn197Lys Uncertain significance Single submitter
- GLRA3 p.Glu457Lys Uncertain significance Single submitter
- GLRA3 p.Gly387Glu Uncertain significance Single submitter
- GLRA3 p.Gly82Ser Uncertain significance Single submitter
- GLRA3 p.Ile243Thr Uncertain significance Single submitter
- GLRA3 p.Thr166Ser Uncertain significance Single submitter
- GLRA3 p.Thr430Ile Uncertain significance Single submitter
- GLRA3 p.Val211Ala Uncertain significance Single submitter
All GLRA3 variants
Benign 1
- p.Thr9= Multiple submitters
Uncertain significance 50
- p.Ala284Ser Single submitter ⚠
- p.Ala2Thr Single submitter ⚠
- p.Ala34Glu Single submitter ⚠
- p.Ala39Pro Single submitter ⚠
- p.Ala434Gly Single submitter ⚠
- p.Arg229Leu Single submitter ⚠
- p.Arg251Gln Single submitter ⚠
- p.Arg251Gly Single submitter ⚠
- p.Arg351Leu Single submitter
- p.Arg35Ser Single submitter ⚠
- p.Arg37Gln Single submitter ⚠
- p.Arg424Trp Single submitter ⚠
- p.Arg5Gly Single submitter ⚠
- p.Asn197Lys Single submitter ⚠
- p.Asn278Thr Single submitter ⚠
- p.Asn404Ser Single submitter ⚠
- p.Asp423Asn Single submitter ⚠
- p.Asp464Gly Single submitter ⚠
- p.Cys435Ser Single submitter ⚠
- p.Cys74Trp Single submitter ⚠
- p.Gln463Pro Single submitter ⚠
- p.Glu457Lys Single submitter ⚠
- p.Gly387Glu Single submitter ⚠
- p.Gly402Val Single submitter ⚠
- p.Gly82Ser Single submitter ⚠
- p.His456Arg Single submitter ⚠
- p.Ile243Thr Single submitter ⚠
- p.Ile459Met Single submitter ⚠
- p.Leu215Phe Single submitter ⚠
- p.Leu25Met Single submitter ⚠
- p.Lys137Arg Single submitter ⚠
- p.Met187Thr Single submitter ⚠
- p.Met388Lys Single submitter ⚠
- p.Met417Lys Single submitter
- p.Phe383Val Single submitter ⚠
- p.Pro120Ser Single submitter ⚠
- p.Ser191Gly Single submitter ⚠
- p.Thr166Ser Single submitter ⚠
- p.Thr216Ser Single submitter ⚠
- p.Thr241Ala Single submitter ⚠
- p.Thr28Ile Single submitter ⚠
- p.Thr430Ile Single submitter ⚠
- p.Thr9Ile Single submitter ⚠
- p.Tyr312Asp Single submitter ⚠
- p.Tyr451Cys Single submitter ⚠
- p.Val209Ile Single submitter ⚠
- p.Val211Ala Single submitter ⚠
- p.Val26Phe Single submitter ⚠
- p.Val293Met Single submitter ⚠
- p.Val409Ile Single submitter ⚠