Sugi Variant

Sugi Variant/GLRB

GLRB — 448 ClinVar variants

All ClinVar germline GLRB variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 159 flagged for review →

17 Pathogenic · 1 Pathogenic/Likely pathogenic · 3 Likely pathogenic · 10 Conflicting · 44 Benign · 10 Benign/Likely benign · 154 Likely benign · 209 Uncertain significance

Full GLRB gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions

⚑ Evidence disagreements 159

Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.

Predictors agree, ClinVar conflicts 6

ClinVar submitters conflict, but the independent predictors unanimously agree — a QC review flag, not a reclassification.

Predictors lean, ClinVar uncertain 104

ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.

Predictors split 49

The independent predictors disagree with each other — read with care.

All GLRB variants

Pathogenic 17

Pathogenic/Likely pathogenic 1

  • c.610+5G>A Multiple submitters GLRB-related disorders

Likely pathogenic 3

Conflicting classifications of pathogenicity 10

Benign 44

Benign/Likely benign 10

Likely benign 154

Uncertain significance 209