GLRX3 — 48 ClinVar variants
All ClinVar germline GLRX3 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 45 flagged for review →
1 Benign · 1 Likely benign · 46 Uncertain significance
Full GLRX3 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 45
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 30
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- GLRX3 p.Ala105Val Uncertain significance Single submitter
- GLRX3 p.Ala116Glu Uncertain significance Single submitter
- GLRX3 p.Ala11Ser Uncertain significance Single submitter
- GLRX3 p.Ala11Thr Uncertain significance Single submitter
- GLRX3 p.Ala143Gly Uncertain significance Single submitter
- GLRX3 p.Ala3Val Uncertain significance Single submitter
- GLRX3 p.Ala5Thr Uncertain significance Single submitter
- GLRX3 p.Arg188Gln Uncertain significance Single submitter
- GLRX3 p.Arg290Trp Uncertain significance Single submitter
- GLRX3 p.Arg99Gln Uncertain significance Single submitter
- GLRX3 p.Asn173His Uncertain significance Single submitter
- GLRX3 p.Glu310Asp Uncertain significance Single submitter
- GLRX3 p.Glu51Lys Uncertain significance Single submitter
- GLRX3 p.Gly119Asp Uncertain significance Single submitter
- GLRX3 p.Gly4Arg Uncertain significance Single submitter
- GLRX3 p.Ile181Val Uncertain significance Single submitter
- GLRX3 p.Leu133Ile Uncertain significance Single submitter
- GLRX3 p.Leu34Val Uncertain significance Single submitter
- GLRX3 p.Pro41Ser Uncertain significance Single submitter
- GLRX3 p.Ser118Asn Uncertain significance Single submitter
- GLRX3 p.Ser118Gly Uncertain significance Single submitter
- GLRX3 p.Ser162Asn Uncertain significance Single submitter
- GLRX3 p.Thr141Ala Uncertain significance Single submitter
- GLRX3 p.Thr199Ala Uncertain significance Single submitter
- GLRX3 p.Thr227Arg Uncertain significance Single submitter
- GLRX3 p.Thr301Ser Uncertain significance Single submitter
- GLRX3 p.Trp197Cys Uncertain significance Single submitter
- GLRX3 p.Val10Gly Uncertain significance Single submitter
- GLRX3 p.Val241Leu Uncertain significance Single submitter
- GLRX3 p.Val276Ile Uncertain significance Single submitter
Predictors split 15
The independent predictors disagree with each other — read with care.
- GLRX3 p.Ala2Val Uncertain significance Single submitter
- GLRX3 p.Arg136His Uncertain significance Single submitter
- GLRX3 p.Asp132Gly Uncertain significance Single submitter
- GLRX3 p.Asp132Val Uncertain significance Single submitter
- GLRX3 p.Glu220Lys Uncertain significance Single submitter
- GLRX3 p.Glu224Lys Uncertain significance Single submitter
- GLRX3 p.Glu326Ala Uncertain significance Single submitter
- GLRX3 p.His172Arg Uncertain significance Single submitter
- GLRX3 p.Leu148Val Uncertain significance Single submitter
- GLRX3 p.Lys171Glu Uncertain significance Single submitter
- GLRX3 p.Met147Val Uncertain significance Single submitter
- GLRX3 p.Met53Ile Uncertain significance Single submitter
- GLRX3 p.Ser18Leu Uncertain significance Single submitter
- GLRX3 p.Ser32Phe Uncertain significance Single submitter
- GLRX3 p.Ser94Phe Uncertain significance Single submitter
All GLRX3 variants
Benign 1
- p.Gln164= Multiple submitters
Likely benign 1
- p.Glu14Val Single submitter
Uncertain significance 46
- p.Ala105Val Single submitter ⚠
- p.Ala116Glu Single submitter ⚠
- p.Ala11Ser Single submitter ⚠
- p.Ala11Thr Single submitter ⚠
- p.Ala143Gly Single submitter ⚠
- p.Ala2Val Single submitter ⚠
- p.Ala3Val Single submitter ⚠
- p.Ala5Thr Single submitter ⚠
- p.Arg136His Single submitter ⚠
- p.Arg188Gln Single submitter ⚠
- p.Arg290Trp Single submitter ⚠
- p.Arg99Gln Single submitter ⚠
- p.Asn173His Single submitter ⚠
- p.Asp132Gly Single submitter ⚠
- p.Asp132Val Single submitter ⚠
- p.Glu208Ala Single submitter
- p.Glu220Lys Single submitter ⚠
- p.Glu224Lys Single submitter ⚠
- p.Glu310Asp Single submitter ⚠
- p.Glu326Ala Single submitter ⚠
- p.Glu51Lys Single submitter ⚠
- p.Gly119Asp Single submitter ⚠
- p.Gly4Arg Single submitter ⚠
- p.His172Arg Single submitter ⚠
- p.Ile181Val Single submitter ⚠
- p.Leu133Ile Single submitter ⚠
- p.Leu148Val Single submitter ⚠
- p.Leu34Val Single submitter ⚠
- p.Lys171Glu Single submitter ⚠
- p.Met147Val Single submitter ⚠
- p.Met53Ile Single submitter ⚠
- p.Pro41Ser Single submitter ⚠
- p.Ser118Asn Single submitter ⚠
- p.Ser118Gly Single submitter ⚠
- p.Ser162Asn Single submitter ⚠
- p.Ser18Leu Single submitter ⚠
- p.Ser32Phe Single submitter ⚠
- p.Ser94Phe Single submitter ⚠
- p.Thr141Ala Single submitter ⚠
- p.Thr199Ala Single submitter ⚠
- p.Thr227Arg Single submitter ⚠
- p.Thr301Ser Single submitter ⚠
- p.Trp197Cys Single submitter ⚠
- p.Val10Gly Single submitter ⚠
- p.Val241Leu Single submitter ⚠
- p.Val276Ile Single submitter ⚠