GLS2 — 67 ClinVar variants
All ClinVar germline GLS2 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 60 flagged for review →
1 Benign · 3 Likely benign · 63 Uncertain significance
Full GLS2 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 60
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 52
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- GLS2 p.Ala365Ser Uncertain significance Single submitter
- GLS2 p.Ala420Thr Uncertain significance Single submitter
- GLS2 p.Ala6Val Uncertain significance Single submitter
- GLS2 p.Arg107Gln Uncertain significance Single submitter
- GLS2 p.Arg107Pro Uncertain significance Single submitter
- GLS2 p.Arg130Gln Uncertain significance Single submitter
- GLS2 p.Arg166His Uncertain significance Single submitter
- GLS2 p.Arg387Cys Uncertain significance Single submitter
- GLS2 p.Arg471Gln Uncertain significance Single submitter
- GLS2 p.Arg483Gln Uncertain significance Single submitter
- GLS2 p.Arg483Trp Uncertain significance Single submitter
- GLS2 p.Arg520His Uncertain significance Single submitter
- GLS2 p.Arg520Leu Uncertain significance Single submitter
- GLS2 p.Asn252Lys Uncertain significance Single submitter
- GLS2 p.Asn301Ser Uncertain significance Single submitter
- GLS2 p.Asp202Gly Uncertain significance Single submitter
- GLS2 p.Asp60Tyr Uncertain significance Single submitter
- GLS2 p.Gln293Lys Uncertain significance Single submitter
- GLS2 p.Gln562Leu Uncertain significance Single submitter
- GLS2 p.Gln57Leu Uncertain significance Single submitter
- GLS2 p.Glu49Gly Uncertain significance Single submitter
- GLS2 p.Glu540Lys Uncertain significance Single submitter
- GLS2 p.Gly22Ser Uncertain significance Single submitter
- GLS2 p.Gly300Arg Uncertain significance Single submitter
- GLS2 p.Gly479Arg Uncertain significance Single submitter
- GLS2 p.Gly530Glu Uncertain significance Single submitter
- GLS2 p.Gly67Asp Uncertain significance Single submitter
- GLS2 p.Ile80Val Uncertain significance Single submitter
- GLS2 p.Leu224Pro Uncertain significance Single submitter
- GLS2 p.Leu328Ile Uncertain significance Single submitter
- GLS2 p.Leu32Phe Uncertain significance Single submitter
- GLS2 p.Leu581Phe Uncertain significance Single submitter
- GLS2 p.Leu69Arg Uncertain significance Single submitter
- GLS2 p.Lys172Arg Uncertain significance Single submitter
- GLS2 p.Lys253Gln Uncertain significance Single submitter
- GLS2 p.Lys253Thr Uncertain significance Single submitter
- GLS2 p.Met266Ile Uncertain significance Single submitter
- GLS2 p.Met304Val Uncertain significance Single submitter
- GLS2 p.Met393Arg Uncertain significance Single submitter
- GLS2 p.Met4Ile Uncertain significance Single submitter
- GLS2 p.Met510Thr Uncertain significance Single submitter
- GLS2 p.Met68Thr Uncertain significance Single submitter
- GLS2 p.Phe311Tyr Uncertain significance Single submitter
- GLS2 p.Pro223Leu Uncertain significance Single submitter
- GLS2 p.Ser456Pro Uncertain significance Single submitter
- GLS2 p.Ser53Cys Uncertain significance Single submitter
- GLS2 p.Thr232Ser Uncertain significance Single submitter
- GLS2 p.Tyr495Cys Uncertain significance Single submitter
- GLS2 p.Tyr517His Uncertain significance Single submitter
- GLS2 p.Val274Ile Uncertain significance Single submitter
- GLS2 p.Val353Leu Uncertain significance Single submitter
- GLS2 p.Val362Ile Uncertain significance Single submitter
Predictors split 8
The independent predictors disagree with each other — read with care.
- GLS2 p.Arg166Cys Uncertain significance Single submitter
- GLS2 p.Arg37Trp Uncertain significance Single submitter
- GLS2 p.Arg471Trp Uncertain significance Single submitter
- GLS2 p.Glu378Lys Uncertain significance Single submitter
- GLS2 p.Gly325Ser Uncertain significance Single submitter
- GLS2 p.Ile228Thr Uncertain significance Single submitter
- GLS2 p.Leu233Arg Uncertain significance Single submitter
- GLS2 p.Leu557Arg Uncertain significance Single submitter
All GLS2 variants
Benign 1
- p.Gly337= Multiple submitters
Likely benign 3
- c.929+3A>G Single submitter
- p.Arg86Gln Single submitter
- p.Leu367= Single submitter
Uncertain significance 63
- p.Ala365Ser Single submitter ⚠
- p.Ala420Thr Single submitter ⚠
- p.Ala6Val Single submitter ⚠
- p.Arg107Gln Single submitter ⚠
- p.Arg107Pro Single submitter ⚠
- p.Arg130Gln Single submitter ⚠
- p.Arg130Ter Single submitter
- p.Arg166Cys Single submitter ⚠
- p.Arg166His Single submitter ⚠
- p.Arg320Gln Single submitter
- p.Arg37Trp Single submitter ⚠
- p.Arg387Cys Single submitter ⚠
- p.Arg471Gln Single submitter ⚠
- p.Arg471Trp Single submitter ⚠
- p.Arg483Gln Single submitter ⚠
- p.Arg483Trp Single submitter ⚠
- p.Arg520His Single submitter ⚠
- p.Arg520Leu Single submitter ⚠
- p.Asn252Lys Single submitter ⚠
- p.Asn301Ser Single submitter ⚠
- p.Asp202Gly Single submitter ⚠
- p.Asp60Tyr Single submitter ⚠
- p.Gln293Lys Single submitter ⚠
- p.Gln562Leu Single submitter ⚠
- p.Gln57Leu Single submitter ⚠
- p.Glu378Lys Single submitter ⚠
- p.Glu49Gly Single submitter ⚠
- p.Glu540Lys Single submitter ⚠
- p.Gly22Ser Single submitter ⚠
- p.Gly300Arg Single submitter ⚠
- p.Gly325Ser Single submitter ⚠
- p.Gly479Arg Single submitter ⚠
- p.Gly530Glu Single submitter ⚠
- p.Gly67Asp Single submitter ⚠
- p.Ile228Thr Single submitter ⚠
- p.Ile80Val Single submitter ⚠
- p.Leu224Pro Single submitter ⚠
- p.Leu233Arg Single submitter ⚠
- p.Leu328Ile Single submitter ⚠
- p.Leu32Phe Single submitter ⚠
- p.Leu557Arg Single submitter ⚠
- p.Leu581Phe Single submitter ⚠
- p.Leu69Arg Single submitter ⚠
- p.Lys172Arg Single submitter ⚠
- p.Lys253Gln Single submitter ⚠
- p.Lys253Thr Single submitter ⚠
- p.Met266Ile Single submitter ⚠
- p.Met304Val Single submitter ⚠
- p.Met393Arg Single submitter ⚠
- p.Met4Ile Single submitter ⚠
- p.Met510Thr Single submitter ⚠
- p.Met68Thr Single submitter ⚠
- p.Phe311Tyr Single submitter ⚠
- p.Pro223Leu Single submitter ⚠
- p.Ser456Pro Single submitter ⚠
- p.Ser53Cys Single submitter ⚠
- p.Thr232Ser Single submitter ⚠
- p.Tyr495Cys Single submitter ⚠
- p.Tyr517His Single submitter ⚠
- p.Val208Glu Single submitter
- p.Val274Ile Single submitter ⚠
- p.Val353Leu Single submitter ⚠
- p.Val362Ile Single submitter ⚠