GMFG — 21 ClinVar variants
All ClinVar germline GMFG variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 20 flagged for review →
21 Uncertain significance
Full GMFG gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 20
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 16
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- GMFG p.Arg142His Uncertain significance Single submitter
- GMFG p.Arg22Cys Uncertain significance Single submitter
- GMFG p.Arg40Gln Uncertain significance Single submitter
- GMFG p.Arg40Gly Uncertain significance Single submitter
- GMFG p.Arg81Gln Uncertain significance Single submitter
- GMFG p.Asp28Asn Uncertain significance Single submitter
- GMFG p.Glu26Gln Uncertain significance Single submitter
- GMFG p.Glu9Ala Uncertain significance Single submitter
- GMFG p.Glu9Lys Uncertain significance Single submitter
- GMFG p.Lys58Ile Uncertain significance Single submitter
- GMFG p.Met103Leu Uncertain significance Single submitter
- GMFG p.Met42Thr Uncertain significance Single submitter
- GMFG p.Pro62Arg Uncertain significance Single submitter
- GMFG p.Pro62Leu Uncertain significance Single submitter
- GMFG p.Thr130Ser Uncertain significance Single submitter
- GMFG p.Val10Ile Uncertain significance Single submitter
Predictors split 4
The independent predictors disagree with each other — read with care.
All GMFG variants
Uncertain significance 21
- p.Arg142His Single submitter ⚠
- p.Arg142Leu Single submitter ⚠
- p.Arg22Cys Single submitter ⚠
- p.Arg40Gln Single submitter ⚠
- p.Arg40Gly Single submitter ⚠
- p.Arg81Gln Single submitter ⚠
- p.Asp28Asn Single submitter ⚠
- p.Glu26Gln Single submitter ⚠
- p.Glu9Ala Single submitter ⚠
- p.Glu9Lys Single submitter ⚠
- p.Leu45Pro Single submitter
- p.Lys58Ile Single submitter ⚠
- p.Met103Leu Single submitter ⚠
- p.Met42Thr Single submitter ⚠
- p.Phe49Leu Single submitter ⚠
- p.Pro12Leu Single submitter ⚠
- p.Pro62Arg Single submitter ⚠
- p.Pro62Leu Single submitter ⚠
- p.Thr130Ser Single submitter ⚠
- p.Val10Ile Single submitter ⚠
- p.Val76Gly Single submitter ⚠