GPAM — 99 ClinVar variants

All ClinVar germline GPAM variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 91 flagged for review →

4 Benign · 3 Likely benign · 92 Uncertain significance

Full GPAM gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions

⚑ Evidence disagreements 91

Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.

Predictors lean, ClinVar uncertain 58

ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.

Predictors split 33

The independent predictors disagree with each other — read with care.

All GPAM variants

Benign 4

p.Ala420Val Multiple submitters
p.Asp399= Multiple submitters
p.Ile43Val Multiple submitters
c.1222-13dup Single submitter

Likely benign 3

p.Ile760Val Single submitter
p.Val163Ile Single submitter
p.Val739Ile Single submitter

Uncertain significance 92

c.102+1G>A Single submitter
p.Ala144Thr Single submitter ⚠
p.Ala144Val Single submitter ⚠
p.Ala327Thr Single submitter ⚠
p.Ala382Thr Single submitter ⚠
p.Ala401Thr Single submitter ⚠
p.Ala518Val Single submitter ⚠
p.Ala536Gly Single submitter ⚠
p.Ala5Pro Single submitter ⚠
p.Ala5Val Single submitter ⚠
p.Ala619Val Single submitter ⚠
p.Ala736Val Single submitter ⚠
p.Arg102Cys Single submitter ⚠
p.Arg102His Single submitter ⚠
p.Arg279Ser Single submitter ⚠
p.Arg305Gln Single submitter ⚠
p.Arg305Pro Single submitter ⚠
p.Arg383Ser Single submitter ⚠
p.Arg453Gly Single submitter ⚠
p.Arg45Gly Single submitter ⚠
p.Arg45Ile Single submitter ⚠
p.Arg463Ser Single submitter ⚠
p.Arg497Thr Single submitter ⚠
p.Arg58Trp Single submitter ⚠
p.Arg617Gln Single submitter ⚠
p.Arg617Gly Single submitter ⚠
p.Asn128Ser Single submitter ⚠
p.Asn198Ile Single submitter ⚠
p.Asn203Ser Single submitter ⚠
p.Asn221Ser Single submitter ⚠
p.Asn342Ser Single submitter ⚠
p.Asp153His Single submitter ⚠
p.Asp346His Single submitter ⚠
p.Asp442Gly Single submitter ⚠
p.Asp553His Single submitter ⚠
p.Cys245Tyr Single submitter ⚠
p.Cys326Arg Single submitter ⚠
p.Cys326Tyr Single submitter ⚠
p.Cys704Arg Single submitter ⚠
p.Gln307His Single submitter ⚠
p.Gln415Lys Single submitter ⚠
p.Gln498Arg Single submitter ⚠
p.Gln652Lys Single submitter ⚠
p.Gln701His Single submitter ⚠
p.Glu515Lys Single submitter ⚠
p.Glu568Asp Single submitter ⚠
p.Glu568Lys Single submitter ⚠
p.Glu96Lys Single submitter ⚠
p.Gly444Arg Single submitter ⚠
p.Gly630Ser Single submitter ⚠
p.Gly648Arg Single submitter ⚠
p.Gly744Ser Single submitter ⚠
p.His486Asp Single submitter ⚠
p.His578Arg Single submitter ⚠
p.Ile432Val Single submitter ⚠
p.Ile500Thr Single submitter ⚠
p.Ile557Val Single submitter ⚠
p.Ile586Thr Single submitter ⚠
p.Ile667Thr Single submitter ⚠
p.Leu296Phe Single submitter ⚠
p.Leu310Trp Single submitter ⚠
p.Leu369Pro Single submitter ⚠
p.Leu424Pro Single submitter ⚠
p.Leu517Val Single submitter ⚠
p.Leu55Ile Single submitter ⚠
p.Lys416Thr Single submitter ⚠
p.Lys478Glu Single submitter ⚠
p.Lys757Arg Single submitter ⚠
p.Lys796Arg Single submitter ⚠
p.Lys798Thr Single submitter ⚠
p.Met185Val Single submitter ⚠
p.Met512Ile Single submitter ⚠
p.Met56Lys Single submitter ⚠
p.Met785Ile Single submitter ⚠
p.Phe650Val Single submitter ⚠
p.Pro223Leu Single submitter ⚠
p.Pro417Leu Single submitter ⚠
p.Pro41Ser Single submitter ⚠
p.Pro559Ala Single submitter ⚠
p.Pro635Ser Single submitter ⚠
p.Pro747Leu Single submitter ⚠
p.Ser136Asn Single submitter ⚠
p.Ser340Phe Single submitter ⚠
p.Ser711Cys Single submitter ⚠
p.Thr10Ala Single submitter ⚠
p.Thr266Ile Single submitter ⚠
p.Thr761Ile Single submitter ⚠
p.Trp676Gly Single submitter ⚠
p.Tyr356Cys Single submitter ⚠
p.Val192Leu Single submitter ⚠
p.Val511Met Single submitter ⚠
p.Val800Gly Single submitter ⚠