Sugi Variant

Sugi Variant/GPC4

GPC4 — 147 ClinVar variants

All ClinVar germline GPC4 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 83 flagged for review →

7 Pathogenic · 9 Likely pathogenic · 7 Conflicting · 8 Benign · 2 Benign/Likely benign · 33 Likely benign · 81 Uncertain significance

Full GPC4 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions

⚑ Evidence disagreements 83

Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.

Predictors vs ClinVar 1

ClinVar calls these pathogenic, but the computational predictors lean tolerated — the highest-value review flag.

Predictors agree, ClinVar conflicts 6

ClinVar submitters conflict, but the independent predictors unanimously agree — a QC review flag, not a reclassification.

Predictors lean, ClinVar uncertain 66

ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.

Predictors split 10

The independent predictors disagree with each other — read with care.

All GPC4 variants

Pathogenic 7

Likely pathogenic 9

Conflicting classifications of pathogenicity 7

Benign 8

Benign/Likely benign 2

Likely benign 33

Uncertain significance 81