GPER1 — 62 ClinVar variants
All ClinVar germline GPER1 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 55 flagged for review →
2 Benign · 3 Likely benign · 57 Uncertain significance
Full GPER1 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 55
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 52
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- GPER1 p.Ala104Val Uncertain significance Single submitter
- GPER1 p.Ala162Val Uncertain significance Single submitter
- GPER1 p.Ala195Thr Uncertain significance Single submitter
- GPER1 p.Ala19Ser Uncertain significance Single submitter
- GPER1 p.Ala244Val Uncertain significance Single submitter
- GPER1 p.Ala355Ser Uncertain significance Single submitter
- GPER1 p.Ala41Thr Uncertain significance Single submitter
- GPER1 p.Arg122Trp Uncertain significance Single submitter
- GPER1 p.Arg164His Uncertain significance Single submitter
- GPER1 p.Arg175Trp Uncertain significance Single submitter
- GPER1 p.Arg248Cys Uncertain significance Single submitter
- GPER1 p.Arg286Gln Uncertain significance Single submitter
- GPER1 p.Arg286Pro Uncertain significance Single submitter
- GPER1 p.Arg286Trp Uncertain significance Single submitter
- GPER1 p.Asp2Val Uncertain significance Single submitter
- GPER1 p.Asp368Asn Uncertain significance Single submitter
- GPER1 p.Asp95His Uncertain significance Single submitter
- GPER1 p.Gln6Glu Uncertain significance Single submitter
- GPER1 p.Glu121Ala Uncertain significance Single submitter
- GPER1 p.Glu121Lys Uncertain significance Single submitter
- GPER1 p.Glu30Lys Uncertain significance Single submitter
- GPER1 p.Glu365Lys Uncertain significance Single submitter
- GPER1 p.Gly249Glu Uncertain significance Single submitter
- GPER1 p.Gly290Arg Uncertain significance Single submitter
- GPER1 p.Gly45Arg Uncertain significance Single submitter
- GPER1 p.His245Gln Uncertain significance Single submitter
- GPER1 p.His353Gln Uncertain significance Single submitter
- GPER1 p.Ile181Val Uncertain significance Single submitter
- GPER1 p.Ile230Met Uncertain significance Single submitter
- GPER1 p.Ile72Val Uncertain significance Single submitter
- GPER1 p.Leu232Pro Uncertain significance Single submitter
- GPER1 p.Leu69Ile Uncertain significance Single submitter
- GPER1 p.Met91Leu Uncertain significance Single submitter
- GPER1 p.Phe351Leu Uncertain significance Single submitter
- GPER1 p.Pro21Ala Uncertain significance Single submitter
- GPER1 p.Pro36Arg Uncertain significance Single submitter
- GPER1 p.Pro36Leu Uncertain significance Single submitter
- GPER1 p.Ser297Tyr Uncertain significance Single submitter
- GPER1 p.Ser315Cys Uncertain significance Single submitter
- GPER1 p.Ser367Leu Uncertain significance Single submitter
- GPER1 p.Ser373Asn Uncertain significance Single submitter
- GPER1 p.Ser373Thr Uncertain significance Single submitter
- GPER1 p.Thr189Met Uncertain significance Single submitter
- GPER1 p.Thr305Met Uncertain significance Single submitter
- GPER1 p.Thr330Ser Uncertain significance Single submitter
- GPER1 p.Thr4Ile Uncertain significance Single submitter
- GPER1 p.Thr66Ala Uncertain significance Single submitter
- GPER1 p.Val186Met Uncertain significance Single submitter
- GPER1 p.Val225Met Uncertain significance Single submitter
- GPER1 p.Val277Ala Uncertain significance Single submitter
- GPER1 p.Val56Met Uncertain significance Single submitter
- GPER1 p.Val83Ala Uncertain significance Single submitter
Predictors split 3
The independent predictors disagree with each other — read with care.
All GPER1 variants
Benign 2
- p.Pro16Leu Single submitter
- p.Ser5Phe Single submitter
Likely benign 3
- p.Asp368Glu Single submitter
- p.Ile230= Single submitter
- p.Val270Ile Single submitter
Uncertain significance 57
- p.Ala104Val Single submitter ⚠
- p.Ala162Val Single submitter ⚠
- p.Ala195Thr Single submitter ⚠
- p.Ala19Ser Single submitter ⚠
- p.Ala244Val Single submitter ⚠
- p.Ala355Ser Single submitter ⚠
- p.Ala41Thr Single submitter ⚠
- p.Arg122Trp Single submitter ⚠
- p.Arg164His Single submitter ⚠
- p.Arg175Trp Single submitter ⚠
- p.Arg248Cys Single submitter ⚠
- p.Arg286Gln Single submitter ⚠
- p.Arg286Pro Single submitter ⚠
- p.Arg286Trp Single submitter ⚠
- p.Asp2Val Single submitter ⚠
- p.Asp368Asn Single submitter ⚠
- p.Asp95His Single submitter ⚠
- p.Gln6Glu Single submitter ⚠
- p.Glu121Ala Single submitter ⚠
- p.Glu121Lys Single submitter ⚠
- p.Glu275Gly Single submitter ⚠
- p.Glu30Lys Single submitter ⚠
- p.Glu365Lys Single submitter ⚠
- p.Gly249Glu Single submitter ⚠
- p.Gly290Arg Single submitter ⚠
- p.Gly45Arg Single submitter ⚠
- p.His245Gln Single submitter ⚠
- p.His353Gln Single submitter ⚠
- p.Ile114Thr Single submitter ⚠
- p.Ile181Val Single submitter ⚠
- p.Ile229Thr Single submitter
- p.Ile230Met Single submitter ⚠
- p.Ile72Val Single submitter ⚠
- p.Leu232Pro Single submitter ⚠
- p.Leu284Arg Single submitter
- p.Leu69Ile Single submitter ⚠
- p.Met91Leu Single submitter ⚠
- p.Phe351Leu Single submitter ⚠
- p.Pro21Ala Single submitter ⚠
- p.Pro36Arg Single submitter ⚠
- p.Pro36Leu Single submitter ⚠
- p.Ser297Tyr Single submitter ⚠
- p.Ser315Cys Single submitter ⚠
- p.Ser367Leu Single submitter ⚠
- p.Ser373Asn Single submitter ⚠
- p.Ser373Thr Single submitter ⚠
- p.Thr189Met Single submitter ⚠
- p.Thr305Met Single submitter ⚠
- p.Thr330Ser Single submitter ⚠
- p.Thr4Ile Single submitter ⚠
- p.Thr66Ala Single submitter ⚠
- p.Val186Met Single submitter ⚠
- p.Val225Met Single submitter ⚠
- p.Val264Ala Single submitter ⚠
- p.Val277Ala Single submitter ⚠
- p.Val56Met Single submitter ⚠
- p.Val83Ala Single submitter ⚠