GPR119 — 27 ClinVar variants
All ClinVar germline GPR119 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 23 flagged for review →
1 Benign · 4 Likely benign · 22 Uncertain significance
Full GPR119 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 23
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 14
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- GPR119 p.Ala124Ser Uncertain significance Single submitter
- GPR119 p.Ala209Asp Uncertain significance Single submitter
- GPR119 p.Ala89Thr Uncertain significance Single submitter
- GPR119 p.Arg112His Uncertain significance Single submitter
- GPR119 p.Cys42Arg Uncertain significance Single submitter
- GPR119 p.Gly60Ala Uncertain significance Single submitter
- GPR119 p.Ile10Phe Uncertain significance Single submitter
- GPR119 p.Ile99Met Uncertain significance Single submitter
- GPR119 p.Leu258Val Uncertain significance Single submitter
- GPR119 p.Leu267His Uncertain significance Single submitter
- GPR119 p.Ser272Tyr Uncertain significance Single submitter
- GPR119 p.Tyr257Cys Uncertain significance Single submitter
- GPR119 p.Val259Ala Uncertain significance Single submitter
- GPR119 p.Val297Met Uncertain significance Single submitter
Predictors split 9
The independent predictors disagree with each other — read with care.
- GPR119 p.Arg216Trp Uncertain significance Single submitter
- GPR119 p.Arg287Gln Uncertain significance Single submitter
- GPR119 p.Gly142Arg Uncertain significance Single submitter
- GPR119 p.His164Gln Uncertain significance Single submitter
- GPR119 p.Ile231Thr Uncertain significance Single submitter
- GPR119 p.Ile54Asn Uncertain significance Single submitter
- GPR119 p.Ser322Cys Uncertain significance Single submitter
- GPR119 p.Val121Met Likely benign Single submitter
- GPR119 p.Val9Met Uncertain significance Single submitter
All GPR119 variants
Benign 1
- p.Ser309Leu Multiple submitters
Likely benign 4
- p.Leu236Val Multiple submitters
- p.Arg71Gln Single submitter
- p.Leu47= Single submitter
- p.Val121Met Single submitter ⚠
Uncertain significance 22
- p.Ala124Ser Single submitter ⚠
- p.Ala209Asp Single submitter ⚠
- p.Ala89Thr Single submitter ⚠
- p.Arg112His Single submitter ⚠
- p.Arg216Trp Single submitter ⚠
- p.Arg287Gln Single submitter ⚠
- p.Cys42Arg Single submitter ⚠
- p.Gly142Arg Single submitter ⚠
- p.Gly60Ala Single submitter ⚠
- p.His164Gln Single submitter ⚠
- p.Ile10Phe Single submitter ⚠
- p.Ile231Thr Single submitter ⚠
- p.Ile54Asn Single submitter ⚠
- p.Ile99Met Single submitter ⚠
- p.Leu258Val Single submitter ⚠
- p.Leu267His Single submitter ⚠
- p.Ser272Tyr Single submitter ⚠
- p.Ser322Cys Single submitter ⚠
- p.Tyr257Cys Single submitter ⚠
- p.Val259Ala Single submitter ⚠
- p.Val297Met Single submitter ⚠
- p.Val9Met Single submitter ⚠