GPR132 — 70 ClinVar variants
All ClinVar germline GPR132 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 56 flagged for review →
4 Benign · 9 Likely benign · 57 Uncertain significance
Full GPR132 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 56
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 48
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- GPR132 p.Ala164Ser Uncertain significance Single submitter
- GPR132 p.Ala164Thr Uncertain significance Single submitter
- GPR132 p.Ala256Pro Uncertain significance Single submitter
- GPR132 p.Ala256Val Uncertain significance Single submitter
- GPR132 p.Ala267Gly Uncertain significance Single submitter
- GPR132 p.Ala30Thr Uncertain significance Single submitter
- GPR132 p.Ala354Val Uncertain significance Single submitter
- GPR132 p.Arg103His Uncertain significance Single submitter
- GPR132 p.Arg155Cys Uncertain significance Single submitter
- GPR132 p.Arg221Leu Uncertain significance Single submitter
- GPR132 p.Arg361Lys Uncertain significance Single submitter
- GPR132 p.Asn104Ser Uncertain significance Single submitter
- GPR132 p.Asn34Lys Uncertain significance Single submitter
- GPR132 p.Asn60Thr Uncertain significance Single submitter
- GPR132 p.Asp355Glu Uncertain significance Single submitter
- GPR132 p.Cys370Tyr Uncertain significance Single submitter
- GPR132 p.Gln348Arg Uncertain significance Single submitter
- GPR132 p.Gln348His Uncertain significance Single submitter
- GPR132 p.Glu184Asp Uncertain significance Single submitter
- GPR132 p.Glu184Val Uncertain significance Single submitter
- GPR132 p.Glu318Asp Uncertain significance Single submitter
- GPR132 p.Glu346Lys Uncertain significance Single submitter
- GPR132 p.Glu377Lys Uncertain significance Single submitter
- GPR132 p.Glu378Val Uncertain significance Single submitter
- GPR132 p.Gly198Arg Uncertain significance Single submitter
- GPR132 p.Gly325Val Uncertain significance Single submitter
- GPR132 p.Gly56Glu Uncertain significance Single submitter
- GPR132 p.His356Tyr Uncertain significance Single submitter
- GPR132 p.Ile121Val Uncertain significance Single submitter
- GPR132 p.Ile196Phe Uncertain significance Single submitter
- GPR132 p.Ile306Val Uncertain significance Single submitter
- GPR132 p.Leu28Phe Uncertain significance Single submitter
- GPR132 p.Lys373Asn Uncertain significance Single submitter
- GPR132 p.Pro16Ser Uncertain significance Single submitter
- GPR132 p.Pro366Arg Uncertain significance Single submitter
- GPR132 p.Pro366Thr Uncertain significance Single submitter
- GPR132 p.Thr18Ile Uncertain significance Single submitter
- GPR132 p.Thr312Met Uncertain significance Single submitter
- GPR132 p.Thr32Ile Uncertain significance Single submitter
- GPR132 p.Tyr357Cys Uncertain significance Single submitter
- GPR132 p.Tyr80Cys Uncertain significance Single submitter
- GPR132 p.Tyr80His Uncertain significance Single submitter
- GPR132 p.Val128Ile Uncertain significance Single submitter
- GPR132 p.Val142Met Uncertain significance Single submitter
- GPR132 p.Val264Phe Uncertain significance Single submitter
- GPR132 p.Val302Met Uncertain significance Single submitter
- GPR132 p.Val309Met Uncertain significance Single submitter
- GPR132 p.Val36Met Uncertain significance Single submitter
Predictors split 8
The independent predictors disagree with each other — read with care.
- GPR132 p.Ala159Thr Uncertain significance Single submitter
- GPR132 p.Ala67Glu Uncertain significance Single submitter
- GPR132 p.Arg140Cys Uncertain significance Single submitter
- GPR132 p.Arg221Trp Uncertain significance Single submitter
- GPR132 p.Pro305Ser Uncertain significance Single submitter
- GPR132 p.Ser163Phe Uncertain significance Single submitter
- GPR132 p.Val144Met Uncertain significance Single submitter
- GPR132 p.Val292Glu Uncertain significance Single submitter
All GPR132 variants
Benign 4
- p.Ala352Ser Multiple submitters
- p.Leu169= Multiple submitters
- p.Ser243= Multiple submitters
- p.Phe38= Single submitter
Likely benign 9
- p.Arg153His Single submitter
- p.Arg155His Single submitter
- p.Arg156Gln Single submitter
- p.Glu328Gln Single submitter
- p.Ile166Val Single submitter
- p.Met279Val Single submitter
- p.Pro16Leu Single submitter
- p.Thr180Met Single submitter
- p.Val264Ile Single submitter
Uncertain significance 57
- p.Ala159Thr Single submitter ⚠
- p.Ala164Ser Single submitter ⚠
- p.Ala164Thr Single submitter ⚠
- p.Ala256Pro Single submitter ⚠
- p.Ala256Val Single submitter ⚠
- p.Ala267Gly Single submitter ⚠
- p.Ala30Thr Single submitter ⚠
- p.Ala354Val Single submitter ⚠
- p.Ala67Glu Single submitter ⚠
- p.Arg103His Single submitter ⚠
- p.Arg140Cys Single submitter ⚠
- p.Arg155Cys Single submitter ⚠
- p.Arg221Leu Single submitter ⚠
- p.Arg221Trp Single submitter ⚠
- p.Arg361Lys Single submitter ⚠
- p.Asn104Ser Single submitter ⚠
- p.Asn34Lys Single submitter ⚠
- p.Asn60Thr Single submitter ⚠
- p.Asp355Glu Single submitter ⚠
- p.Cys370Tyr Single submitter ⚠
- p.Gln348Arg Single submitter ⚠
- p.Gln348His Single submitter ⚠
- p.Glu184Asp Single submitter ⚠
- p.Glu184Val Single submitter ⚠
- p.Glu318Asp Single submitter ⚠
- p.Glu346Lys Single submitter ⚠
- p.Glu377Lys Single submitter ⚠
- p.Glu378Val Single submitter ⚠
- p.Gly198Arg Single submitter ⚠
- p.Gly325Val Single submitter ⚠
- p.Gly56Glu Single submitter ⚠
- p.His356Tyr Single submitter ⚠
- p.Ile121Val Single submitter ⚠
- p.Ile196Phe Single submitter ⚠
- p.Ile306Val Single submitter ⚠
- p.Leu28Phe Single submitter ⚠
- p.Lys237Thr Single submitter
- p.Lys373Asn Single submitter ⚠
- p.Pro16Ser Single submitter ⚠
- p.Pro305Ser Single submitter ⚠
- p.Pro366Arg Single submitter ⚠
- p.Pro366Thr Single submitter ⚠
- p.Ser163Phe Single submitter ⚠
- p.Thr18Ile Single submitter ⚠
- p.Thr312Met Single submitter ⚠
- p.Thr32Ile Single submitter ⚠
- p.Tyr357Cys Single submitter ⚠
- p.Tyr80Cys Single submitter ⚠
- p.Tyr80His Single submitter ⚠
- p.Val128Ile Single submitter ⚠
- p.Val142Met Single submitter ⚠
- p.Val144Met Single submitter ⚠
- p.Val264Phe Single submitter ⚠
- p.Val292Glu Single submitter ⚠
- p.Val302Met Single submitter ⚠
- p.Val309Met Single submitter ⚠
- p.Val36Met Single submitter ⚠