GPR139 — 38 ClinVar variants
All ClinVar germline GPR139 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 35 flagged for review →
1 Likely benign · 37 Uncertain significance
Full GPR139 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 35
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 19
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- GPR139 p.Ala242Thr Uncertain significance Single submitter
- GPR139 p.Arg144Cys Uncertain significance Single submitter
- GPR139 p.Arg212Met Uncertain significance Single submitter
- GPR139 p.Arg291Gln Uncertain significance Single submitter
- GPR139 p.Gln258Lys Uncertain significance Single submitter
- GPR139 p.His3Leu Uncertain significance Single submitter
- GPR139 p.Ile205Val Uncertain significance Single submitter
- GPR139 p.Leu14Arg Uncertain significance Single submitter
- GPR139 p.Lys225Arg Uncertain significance Single submitter
- GPR139 p.Lys350Glu Uncertain significance Single submitter
- GPR139 p.Met266Ile Uncertain significance Single submitter
- GPR139 p.Phe231Leu Uncertain significance Single submitter
- GPR139 p.Pro29Ser Uncertain significance Single submitter
- GPR139 p.Ser235Pro Uncertain significance Single submitter
- GPR139 p.Thr138Met Uncertain significance Single submitter
- GPR139 p.Thr322Arg Uncertain significance Single submitter
- GPR139 p.Tyr174Asn Uncertain significance Single submitter
- GPR139 p.Val182Ile Uncertain significance Single submitter
- GPR139 p.Val194Met Uncertain significance Single submitter
Predictors split 16
The independent predictors disagree with each other — read with care.
- GPR139 p.Arg291Pro Uncertain significance Single submitter
- GPR139 p.Arg57Ser Uncertain significance Single submitter
- GPR139 p.Asp89Glu Uncertain significance Single submitter
- GPR139 p.Cys156Phe Uncertain significance Single submitter
- GPR139 p.Ile124Thr Uncertain significance Single submitter
- GPR139 p.Ile149Thr Uncertain significance Single submitter
- GPR139 p.Ile184Ser Uncertain significance Single submitter
- GPR139 p.Phe79Leu Uncertain significance Single submitter
- GPR139 p.Phe82Leu Uncertain significance Single submitter
- GPR139 p.Pro121Leu Uncertain significance Single submitter
- GPR139 p.Pro142Thr Uncertain significance Single submitter
- GPR139 p.Ser34Ile Uncertain significance Single submitter
- GPR139 p.Thr226Ser Uncertain significance Single submitter
- GPR139 p.Thr322Ile Uncertain significance Single submitter
- GPR139 p.Tyr33His Uncertain significance Single submitter
- GPR139 p.Val81Gly Uncertain significance Single submitter
All GPR139 variants
Likely benign 1
- p.Asp101Asn Single submitter
Uncertain significance 37
- p.Ala242Thr Single submitter ⚠
- p.Ala330Val Single submitter
- p.Arg144Cys Single submitter ⚠
- p.Arg144His Single submitter
- p.Arg212Met Single submitter ⚠
- p.Arg291Gln Single submitter ⚠
- p.Arg291Pro Single submitter ⚠
- p.Arg57Ser Single submitter ⚠
- p.Asp89Glu Single submitter ⚠
- p.Cys156Phe Single submitter ⚠
- p.Gln258Lys Single submitter ⚠
- p.His3Leu Single submitter ⚠
- p.Ile124Thr Single submitter ⚠
- p.Ile149Thr Single submitter ⚠
- p.Ile184Ser Single submitter ⚠
- p.Ile205Val Single submitter ⚠
- p.Leu14Arg Single submitter ⚠
- p.Lys225Arg Single submitter ⚠
- p.Lys350Glu Single submitter ⚠
- p.Met266Ile Single submitter ⚠
- p.Phe231Leu Single submitter ⚠
- p.Phe79Leu Single submitter ⚠
- p.Phe82Leu Single submitter ⚠
- p.Pro121Leu Single submitter ⚠
- p.Pro142Thr Single submitter ⚠
- p.Pro29Ser Single submitter ⚠
- p.Ser235Pro Single submitter ⚠
- p.Ser34Ile Single submitter ⚠
- p.Thr138Met Single submitter ⚠
- p.Thr226Ser Single submitter ⚠
- p.Thr322Arg Single submitter ⚠
- p.Thr322Ile Single submitter ⚠
- p.Tyr174Asn Single submitter ⚠
- p.Tyr33His Single submitter ⚠
- p.Val182Ile Single submitter ⚠
- p.Val194Met Single submitter ⚠
- p.Val81Gly Single submitter ⚠