GPR142 — 101 ClinVar variants
All ClinVar germline GPR142 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 82 flagged for review →
2 Benign · 2 Benign/Likely benign · 11 Likely benign · 86 Uncertain significance
Full GPR142 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 82
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 73
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- GPR142 c.-124G>A Uncertain significance Single submitter
- GPR142 c.-157G>A Uncertain significance Single submitter
- GPR142 c.-162C>A Uncertain significance Single submitter
- GPR142 c.-178C>G Uncertain significance Single submitter
- GPR142 c.-256A>C Uncertain significance Single submitter
- GPR142 c.-259A>G Uncertain significance Single submitter
- GPR142 c.-263G>A Uncertain significance Single submitter
- GPR142 c.-266G>A Uncertain significance Single submitter
- GPR142 c.-271A>G Uncertain significance Single submitter
- GPR142 c.-27G>A Uncertain significance Single submitter
- GPR142 c.-350A>G Uncertain significance Single submitter
- GPR142 c.-40A>C Uncertain significance Single submitter
- GPR142 c.-45C>G Uncertain significance Single submitter
- GPR142 c.-4G>A Uncertain significance Single submitter
- GPR142 c.-58A>G Uncertain significance Single submitter
- GPR142 c.-61C>T Uncertain significance Single submitter
- GPR142 p.Ala156Thr Uncertain significance Single submitter
- GPR142 p.Ala161Thr Uncertain significance Single submitter
- GPR142 p.Ala283Val Uncertain significance Single submitter
- GPR142 p.Ala320Val Uncertain significance Single submitter
- GPR142 p.Ala60Thr Uncertain significance Single submitter
- GPR142 p.Arg102Met Uncertain significance Single submitter
- GPR142 p.Arg144His Uncertain significance Single submitter
- GPR142 p.Arg179Gln Uncertain significance Single submitter
- GPR142 p.Arg186Gln Uncertain significance Single submitter
- GPR142 p.Arg186Trp Uncertain significance Single submitter
- GPR142 p.Arg188His Uncertain significance Single submitter
- GPR142 p.Arg188Ser Uncertain significance Single submitter
- GPR142 p.Arg189Gln Uncertain significance Single submitter
- GPR142 p.Arg219Lys Uncertain significance Single submitter
- GPR142 p.Arg251Gln Uncertain significance Single submitter
- GPR142 p.Arg251Trp Uncertain significance Single submitter
- GPR142 p.Arg263Gln Uncertain significance Single submitter
- GPR142 p.Arg338Gln Uncertain significance Single submitter
- GPR142 p.Arg95His Uncertain significance Single submitter
- GPR142 p.Asn147Asp Uncertain significance Single submitter
- GPR142 p.Asn312Ser Uncertain significance Single submitter
- GPR142 p.Asp216Asn Uncertain significance Single submitter
- GPR142 p.Asp343Asn Uncertain significance Single submitter
- GPR142 p.Cys6= Uncertain significance Single submitter
- GPR142 p.Gly324Cys Uncertain significance Single submitter
- GPR142 p.Gly47Glu Uncertain significance Single submitter
- GPR142 p.Gly68Ser Uncertain significance Single submitter
- GPR142 p.Gly7= Uncertain significance Single submitter
- GPR142 p.Gly82Glu Uncertain significance Single submitter
- GPR142 p.His177Tyr Uncertain significance Single submitter
- GPR142 p.His299Pro Uncertain significance Single submitter
- GPR142 p.His318Gln Uncertain significance Single submitter
- GPR142 p.Ile118Met Uncertain significance Single submitter
- GPR142 p.Ile162Leu Uncertain significance Single submitter
- GPR142 p.Ile191Val Uncertain significance Single submitter
- GPR142 p.Leu277Val Uncertain significance Single submitter
- GPR142 p.Met293Ile Uncertain significance Single submitter
- GPR142 p.Met313Lys Uncertain significance Single submitter
- GPR142 p.Pro184Arg Uncertain significance Single submitter
- GPR142 p.Pro218Leu Uncertain significance Single submitter
- GPR142 p.Pro297His Uncertain significance Single submitter
- GPR142 p.Pro354Leu Uncertain significance Single submitter
- GPR142 p.Pro354Ser Uncertain significance Single submitter
- GPR142 p.Pro64Ser Uncertain significance Single submitter
- GPR142 p.Ser114Leu Uncertain significance Single submitter
- GPR142 p.Ser246Trp Uncertain significance Single submitter
- GPR142 p.Ser330Arg Uncertain significance Single submitter
- GPR142 p.Ser49Ile Uncertain significance Single submitter
- GPR142 p.Thr112Arg Uncertain significance Single submitter
- GPR142 p.Thr145Ala Uncertain significance Single submitter
- GPR142 p.Thr215Ser Uncertain significance Single submitter
- GPR142 p.Trp207Ser Uncertain significance Single submitter
- GPR142 p.Tyr206Cys Uncertain significance Single submitter
- GPR142 p.Tyr291His Uncertain significance Single submitter
- GPR142 p.Val224Ile Uncertain significance Single submitter
- GPR142 p.Val374Ala Uncertain significance Single submitter
- GPR142 p.Val374Gly Uncertain significance Single submitter
Predictors split 9
The independent predictors disagree with each other — read with care.
- GPR142 p.Arg257Trp Uncertain significance Single submitter
- GPR142 p.Arg263Trp Uncertain significance Single submitter
- GPR142 p.Asn322Ser Uncertain significance Single submitter
- GPR142 p.His305Arg Uncertain significance Single submitter
- GPR142 p.Leu134Pro Uncertain significance Single submitter
- GPR142 p.Phe241Leu Uncertain significance Single submitter
- GPR142 p.Pro103Leu Uncertain significance Single submitter
- GPR142 p.Pro175Thr Uncertain significance Single submitter
- GPR142 p.Thr319Met Uncertain significance Single submitter
All GPR142 variants
Benign 2
- p.Arg36Gln Multiple submitters
- p.Leu128= Multiple submitters
Likely benign 11
- p.Arg285Trp Multiple submitters
- c.-333A>C Single submitter
- p.Ala125Val Single submitter
- p.Ala181Thr Single submitter
- p.Ala359Val Single submitter
- p.Ala90Thr Single submitter
- p.Gln34fs Single submitter
- p.Pro366Leu Single submitter
- p.Ser196= Single submitter
- p.Val120Ala Single submitter
- p.Val133Leu Single submitter
Uncertain significance 86
- c.-124G>A Single submitter ⚠
- c.-157G>A Single submitter ⚠
- c.-162C>A Single submitter ⚠
- c.-178C>G Single submitter ⚠
- c.-256A>C Single submitter ⚠
- c.-259A>G Single submitter ⚠
- c.-263G>A Single submitter ⚠
- c.-266G>A Single submitter ⚠
- c.-271A>G Single submitter ⚠
- c.-27G>A Single submitter ⚠
- c.-350A>G Single submitter ⚠
- c.-40A>C Single submitter ⚠
- c.-45C>G Single submitter ⚠
- c.-4G>A Single submitter ⚠
- c.-58A>G Single submitter ⚠
- c.-61C>T Single submitter ⚠
- p.Ala132Pro Single submitter
- p.Ala156Thr Single submitter ⚠
- p.Ala161Thr Single submitter ⚠
- p.Ala283Val Single submitter ⚠
- p.Ala320Val Single submitter ⚠
- p.Ala60Thr Single submitter ⚠
- p.Arg102Met Single submitter ⚠
- p.Arg144His Single submitter ⚠
- p.Arg179Gln Single submitter ⚠
- p.Arg186Gln Single submitter ⚠
- p.Arg186Trp Single submitter ⚠
- p.Arg188His Single submitter ⚠
- p.Arg188Ser Single submitter ⚠
- p.Arg189Gln Single submitter ⚠
- p.Arg219Lys Single submitter ⚠
- p.Arg251Gln Single submitter ⚠
- p.Arg251Trp Single submitter ⚠
- p.Arg257Trp Single submitter ⚠
- p.Arg263Gln Single submitter ⚠
- p.Arg263Trp Single submitter ⚠
- p.Arg303Ser Single submitter
- p.Arg338Gln Single submitter ⚠
- p.Arg95His Single submitter ⚠
- p.Asn147Asp Single submitter ⚠
- p.Asn312Ser Single submitter ⚠
- p.Asn322Ser Single submitter ⚠
- p.Asp216Asn Single submitter ⚠
- p.Asp343Asn Single submitter ⚠
- p.Cys230Ser Single submitter
- p.Cys6= Single submitter ⚠
- p.Gly324Cys Single submitter ⚠
- p.Gly47Glu Single submitter ⚠
- p.Gly68Ser Single submitter ⚠
- p.Gly7= Single submitter ⚠
- p.Gly82Glu Single submitter ⚠
- p.His177Tyr Single submitter ⚠
- p.His299Pro Single submitter ⚠
- p.His305Arg Single submitter ⚠
- p.His318Gln Single submitter ⚠
- p.Ile118Met Single submitter ⚠
- p.Ile162Leu Single submitter ⚠
- p.Ile191Val Single submitter ⚠
- p.Leu134Pro Single submitter ⚠
- p.Leu277Val Single submitter ⚠
- p.Met293Ile Single submitter ⚠
- p.Met313Lys Single submitter ⚠
- p.Phe241Leu Single submitter ⚠
- p.Pro103Leu Single submitter ⚠
- p.Pro175Thr Single submitter ⚠
- p.Pro184Arg Single submitter ⚠
- p.Pro218Leu Single submitter ⚠
- p.Pro297His Single submitter ⚠
- p.Pro354Leu Single submitter ⚠
- p.Pro354Ser Single submitter ⚠
- p.Pro64Ser Single submitter ⚠
- p.Ser114Leu Single submitter ⚠
- p.Ser246Trp Single submitter ⚠
- p.Ser330Arg Single submitter ⚠
- p.Ser49Ile Single submitter ⚠
- p.Thr112Arg Single submitter ⚠
- p.Thr145Ala Single submitter ⚠
- p.Thr215Ser Single submitter ⚠
- p.Thr319Met Single submitter ⚠
- p.Trp207Ser Single submitter ⚠
- p.Tyr206Cys Single submitter ⚠
- p.Tyr291His Single submitter ⚠
- p.Val123Met Single submitter
- p.Val224Ile Single submitter ⚠
- p.Val374Ala Single submitter ⚠
- p.Val374Gly Single submitter ⚠