GPR174 — 38 ClinVar variants
All ClinVar germline GPR174 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 26 flagged for review →
5 Benign · 6 Likely benign · 27 Uncertain significance
Full GPR174 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 26
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 26
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- GPR174 p.Ala236Ser Uncertain significance Single submitter
- GPR174 p.Ala236Thr Uncertain significance Single submitter
- GPR174 p.Asn297Ser Uncertain significance Single submitter
- GPR174 p.Asn322Ser Uncertain significance Single submitter
- GPR174 p.Asp159Val Uncertain significance Single submitter
- GPR174 p.Cys333Arg Uncertain significance Single submitter
- GPR174 p.Gln313Lys Uncertain significance Single submitter
- GPR174 p.Glu50Lys Uncertain significance Single submitter
- GPR174 p.Ile291Met Uncertain significance Single submitter
- GPR174 p.Ile35Thr Uncertain significance Single submitter
- GPR174 p.Ile38Met Uncertain significance Single submitter
- GPR174 p.Ile59Met Uncertain significance Single submitter
- GPR174 p.Leu155Phe Uncertain significance Single submitter
- GPR174 p.Leu210Ser Uncertain significance Single submitter
- GPR174 p.Lys130Arg Uncertain significance Single submitter
- GPR174 p.Met185Val Uncertain significance Single submitter
- GPR174 p.Met92Ile Uncertain significance Single submitter
- GPR174 p.Phe254Tyr Uncertain significance Single submitter
- GPR174 p.Pro32Ala Uncertain significance Single submitter
- GPR174 p.Ser158Thr Uncertain significance Single submitter
- GPR174 p.Thr187Ser Uncertain significance Single submitter
- GPR174 p.Thr208Met Uncertain significance Single submitter
- GPR174 p.Thr25Ile Uncertain significance Single submitter
- GPR174 p.Tyr133His Uncertain significance Single submitter
- GPR174 p.Tyr216His Uncertain significance Single submitter
- GPR174 p.Val114Ala Uncertain significance Single submitter
All GPR174 variants
Benign 5
- c.-17T>C Multiple submitters
- c.-34C>T Multiple submitters
- p.Thr161= Multiple submitters
- p.Leu202= No assertion criteria GPR174-related disorder
- p.Ser162Pro No assertion criteria GPR174-related disorder
Likely benign 6
- p.Arg125His Single submitter
- p.Gly141= Single submitter
- p.Lys225= Single submitter
- p.Leu74= No assertion criteria GPR174-related disorder
- p.Pro88His No assertion criteria GPR174-related disorder
- p.Ser182= No assertion criteria GPR174-related disorder
Uncertain significance 27
- p.Ala236Ser Single submitter ⚠
- p.Ala236Thr Single submitter ⚠
- p.Ala281Ser Single submitter
- p.Asn297Ser Single submitter ⚠
- p.Asn322Ser Single submitter ⚠
- p.Asp159Val Single submitter ⚠
- p.Cys333Arg Single submitter ⚠
- p.Gln313Lys Single submitter ⚠
- p.Glu50Lys Single submitter ⚠
- p.Ile291Met Single submitter ⚠
- p.Ile35Thr Single submitter ⚠
- p.Ile38Met Single submitter ⚠
- p.Ile59Met Single submitter ⚠
- p.Leu155Phe Single submitter ⚠
- p.Leu210Ser Single submitter ⚠
- p.Lys130Arg Single submitter ⚠
- p.Met185Val Single submitter ⚠
- p.Met92Ile Single submitter ⚠
- p.Phe254Tyr Single submitter ⚠
- p.Pro32Ala Single submitter ⚠
- p.Ser158Thr Single submitter ⚠
- p.Thr187Ser Single submitter ⚠
- p.Thr208Met Single submitter ⚠
- p.Thr25Ile Single submitter ⚠
- p.Tyr133His Single submitter ⚠
- p.Tyr216His Single submitter ⚠
- p.Val114Ala Single submitter ⚠