GPR18 — 51 ClinVar variants
All ClinVar germline GPR18 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 39 flagged for review →
4 Likely benign · 47 Uncertain significance
Full GPR18 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 39
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 36
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- GPR18 p.Ala141Pro Uncertain significance Single submitter
- GPR18 p.Ala253Thr Uncertain significance Single submitter
- GPR18 p.Ala295Thr Uncertain significance Single submitter
- GPR18 p.Arg296Gln Uncertain significance Single submitter
- GPR18 p.Arg311His Uncertain significance Single submitter
- GPR18 p.Arg311Leu Uncertain significance Single submitter
- GPR18 p.Arg316Leu Uncertain significance Single submitter
- GPR18 p.Arg321Trp Uncertain significance Single submitter
- GPR18 p.Asn213Tyr Uncertain significance Single submitter
- GPR18 p.Asn265Ile Uncertain significance Single submitter
- GPR18 p.Cys94Tyr Uncertain significance Single submitter
- GPR18 p.Glu261Gln Uncertain significance Single submitter
- GPR18 p.Glu261Lys Uncertain significance Single submitter
- GPR18 p.Glu329Val Uncertain significance Single submitter
- GPR18 p.Gly217Ser Uncertain significance Single submitter
- GPR18 p.Ile210Val Uncertain significance Single submitter
- GPR18 p.Ile231Leu Uncertain significance Single submitter
- GPR18 p.Ile32Thr Uncertain significance Single submitter
- GPR18 p.Ile34Leu Uncertain significance Single submitter
- GPR18 p.Ile35Thr Uncertain significance Single submitter
- GPR18 p.Ile72Met Uncertain significance Single submitter
- GPR18 p.Leu111Phe Uncertain significance Single submitter
- GPR18 p.Leu26Pro Uncertain significance Single submitter
- GPR18 p.Met301Ile Uncertain significance Single submitter
- GPR18 p.Met330Leu Uncertain significance Single submitter
- GPR18 p.Met73Thr Uncertain significance Single submitter
- GPR18 p.Pro18Ala Uncertain significance Single submitter
- GPR18 p.Pro88Leu Uncertain significance Single submitter
- GPR18 p.Ser106Thr Uncertain significance Single submitter
- GPR18 p.Thr151Ile Uncertain significance Single submitter
- GPR18 p.Thr219Met Uncertain significance Single submitter
- GPR18 p.Thr259Met Uncertain significance Single submitter
- GPR18 p.Thr3Ile Uncertain significance Single submitter
- GPR18 p.Val143Met Uncertain significance Single submitter
- GPR18 p.Val239Leu Uncertain significance Single submitter
- GPR18 p.Val297Ile Uncertain significance Single submitter
Predictors split 3
The independent predictors disagree with each other — read with care.
All GPR18 variants
Likely benign 4
- p.Leu187Met Multiple submitters
- p.His216= Single submitter
- p.Lys161Glu Single submitter
- p.Val186Met Single submitter
Uncertain significance 47
- p.Ala141Pro Single submitter ⚠
- p.Ala253Thr Single submitter ⚠
- p.Ala295Thr Single submitter ⚠
- p.Arg296Gln Single submitter ⚠
- p.Arg311Cys Single submitter
- p.Arg311His Single submitter ⚠
- p.Arg311Leu Single submitter ⚠
- p.Arg316Leu Single submitter ⚠
- p.Arg321Trp Single submitter ⚠
- p.Arg54Ile Single submitter
- p.Asn213Tyr Single submitter ⚠
- p.Asn265Ile Single submitter ⚠
- p.Cys280Ser Single submitter
- p.Cys94Tyr Single submitter ⚠
- p.Glu261Gln Single submitter ⚠
- p.Glu261Lys Single submitter ⚠
- p.Glu329Val Single submitter ⚠
- p.Gly217Ser Single submitter ⚠
- p.Ile210Val Single submitter ⚠
- p.Ile231Leu Single submitter ⚠
- p.Ile288Asn Single submitter ⚠
- p.Ile32Thr Single submitter ⚠
- p.Ile34Leu Single submitter ⚠
- p.Ile35Thr Single submitter ⚠
- p.Ile59Thr Single submitter
- p.Ile72Met Single submitter ⚠
- p.Leu111Phe Single submitter ⚠
- p.Leu26Pro Single submitter ⚠
- p.Met121Thr Single submitter
- p.Met148Thr Single submitter ⚠
- p.Met301Ile Single submitter ⚠
- p.Met330Leu Single submitter ⚠
- p.Met73Thr Single submitter ⚠
- p.Phe245Leu Single submitter ⚠
- p.Pro126Thr Single submitter
- p.Pro18Ala Single submitter ⚠
- p.Pro88Leu Single submitter ⚠
- p.Ser106Thr Single submitter ⚠
- p.Thr151Ile Single submitter ⚠
- p.Thr219Met Single submitter ⚠
- p.Thr259Met Single submitter ⚠
- p.Thr279Met Single submitter
- p.Thr3Ile Single submitter ⚠
- p.Val143Met Single submitter ⚠
- p.Val239Leu Single submitter ⚠
- p.Val297Ile Single submitter ⚠
- p.Val64Leu Single submitter