GPR183 — 44 ClinVar variants
All ClinVar germline GPR183 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 42 flagged for review →
1 Benign · 1 Likely benign · 42 Uncertain significance
Full GPR183 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 42
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 35
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- GPR183 p.Ala30Val Uncertain significance Single submitter
- GPR183 p.Ala6Thr Uncertain significance Single submitter
- GPR183 p.Ala83Ser Uncertain significance Single submitter
- GPR183 p.Arg138His Uncertain significance Single submitter
- GPR183 p.Arg273Cys Uncertain significance Single submitter
- GPR183 p.Arg325Trp Uncertain significance Single submitter
- GPR183 p.Arg344His Uncertain significance Single submitter
- GPR183 p.Asp20Ala Uncertain significance Single submitter
- GPR183 p.Glu189Val Uncertain significance Single submitter
- GPR183 p.Gly18Arg Uncertain significance Single submitter
- GPR183 p.Gly360Arg Uncertain significance Single submitter
- GPR183 p.Ile168Thr Uncertain significance Single submitter
- GPR183 p.Ile331Thr Uncertain significance Single submitter
- GPR183 p.Ile353Thr Uncertain significance Single submitter
- GPR183 p.Ile44Thr Uncertain significance Single submitter
- GPR183 p.Ile99Phe Uncertain significance Single submitter
- GPR183 p.Leu164Phe Uncertain significance Single submitter
- GPR183 p.Leu68Phe Uncertain significance Single submitter
- GPR183 p.Met322Ile Uncertain significance Single submitter
- GPR183 p.Met351Val Uncertain significance Single submitter
- GPR183 p.Pro12Ser Uncertain significance Single submitter
- GPR183 p.Pro170Arg Uncertain significance Single submitter
- GPR183 p.Pro305Ser Uncertain significance Single submitter
- GPR183 p.Ser281Gly Uncertain significance Single submitter
- GPR183 p.Thr15Ser Uncertain significance Single submitter
- GPR183 p.Thr29Met Uncertain significance Single submitter
- GPR183 p.Thr349Ala Uncertain significance Single submitter
- GPR183 p.Tyr315Cys Uncertain significance Single submitter
- GPR183 p.Val251Ile Uncertain significance Single submitter
- GPR183 p.Val262Ala Uncertain significance Single submitter
- GPR183 p.Val294Ile Uncertain significance Single submitter
- GPR183 p.Val329Leu Uncertain significance Single submitter
- GPR183 p.Val33Ala Uncertain significance Single submitter
- GPR183 p.Val41Ile Uncertain significance Single submitter
- GPR183 p.Val47Met Uncertain significance Single submitter
Predictors split 7
The independent predictors disagree with each other — read with care.
- GPR183 p.Ala108Val Uncertain significance Single submitter
- GPR183 p.Cys295Tyr Uncertain significance Single submitter
- GPR183 p.His267Gln Uncertain significance Single submitter
- GPR183 p.Met268Ile Uncertain significance Single submitter
- GPR183 p.Met34Thr Uncertain significance Single submitter
- GPR183 p.Phe310Ser Uncertain significance Single submitter
- GPR183 p.Tyr90Phe Uncertain significance Single submitter
All GPR183 variants
Benign 1
- p.Leu290= Single submitter
Likely benign 1
- p.Ser358Leu Single submitter
Uncertain significance 42
- p.Ala108Val Single submitter ⚠
- p.Ala30Val Single submitter ⚠
- p.Ala6Thr Single submitter ⚠
- p.Ala83Ser Single submitter ⚠
- p.Arg138His Single submitter ⚠
- p.Arg273Cys Single submitter ⚠
- p.Arg325Trp Single submitter ⚠
- p.Arg344His Single submitter ⚠
- p.Asp20Ala Single submitter ⚠
- p.Cys295Tyr Single submitter ⚠
- p.Glu189Val Single submitter ⚠
- p.Gly18Arg Single submitter ⚠
- p.Gly360Arg Single submitter ⚠
- p.His267Gln Single submitter ⚠
- p.Ile168Thr Single submitter ⚠
- p.Ile331Thr Single submitter ⚠
- p.Ile353Thr Single submitter ⚠
- p.Ile44Thr Single submitter ⚠
- p.Ile99Phe Single submitter ⚠
- p.Leu164Phe Single submitter ⚠
- p.Leu68Phe Single submitter ⚠
- p.Met268Ile Single submitter ⚠
- p.Met322Ile Single submitter ⚠
- p.Met34Thr Single submitter ⚠
- p.Met351Val Single submitter ⚠
- p.Phe310Ser Single submitter ⚠
- p.Pro12Ser Single submitter ⚠
- p.Pro170Arg Single submitter ⚠
- p.Pro305Ser Single submitter ⚠
- p.Ser281Gly Single submitter ⚠
- p.Thr15Ser Single submitter ⚠
- p.Thr29Met Single submitter ⚠
- p.Thr349Ala Single submitter ⚠
- p.Tyr315Cys Single submitter ⚠
- p.Tyr90Phe Single submitter ⚠
- p.Val251Ile Single submitter ⚠
- p.Val262Ala Single submitter ⚠
- p.Val294Ile Single submitter ⚠
- p.Val329Leu Single submitter ⚠
- p.Val33Ala Single submitter ⚠
- p.Val41Ile Single submitter ⚠
- p.Val47Met Single submitter ⚠