GPR22 — 28 ClinVar variants
All ClinVar germline GPR22 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 26 flagged for review →
1 Likely benign · 27 Uncertain significance
Full GPR22 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 26
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 20
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- GPR22 p.Ala157Pro Uncertain significance Single submitter
- GPR22 p.Ala399Val Uncertain significance Single submitter
- GPR22 p.Arg20Gln Uncertain significance Single submitter
- GPR22 p.Arg241Gln Uncertain significance Single submitter
- GPR22 p.Asn16Asp Uncertain significance Single submitter
- GPR22 p.Asp270Asn Uncertain significance Single submitter
- GPR22 p.Ile23Thr Uncertain significance Single submitter
- GPR22 p.Ile23Val Uncertain significance Single submitter
- GPR22 p.Ile389Thr Uncertain significance Single submitter
- GPR22 p.Ile414Thr Uncertain significance Single submitter
- GPR22 p.Lys424Arg Uncertain significance Single submitter
- GPR22 p.Pro408Thr Uncertain significance Single submitter
- GPR22 p.Ser35Thr Uncertain significance Single submitter
- GPR22 p.Thr189Asn Uncertain significance Single submitter
- GPR22 p.Thr28Ile Uncertain significance Single submitter
- GPR22 p.Thr432Lys Uncertain significance Single submitter
- GPR22 p.Val133Ile Uncertain significance Single submitter
- GPR22 p.Val225Ala Uncertain significance Single submitter
- GPR22 p.Val281Ile Uncertain significance Single submitter
- GPR22 p.Val64Ala Uncertain significance Single submitter
Predictors split 6
The independent predictors disagree with each other — read with care.
- GPR22 p.Ala293Gly Uncertain significance Single submitter
- GPR22 p.Gln216Arg Uncertain significance Single submitter
- GPR22 p.Ile292Thr Uncertain significance Single submitter
- GPR22 p.Ile401Thr Uncertain significance Single submitter
- GPR22 p.Lys379Asn Uncertain significance Single submitter
- GPR22 p.Thr321Ile Uncertain significance Single submitter
All GPR22 variants
Likely benign 1
- p.Asp418= Single submitter
Uncertain significance 27
- p.Ala157Pro Single submitter ⚠
- p.Ala293Gly Single submitter ⚠
- p.Ala399Val Single submitter ⚠
- p.Arg20Gln Single submitter ⚠
- p.Arg241Gln Single submitter ⚠
- p.Asn16Asp Single submitter ⚠
- p.Asp270Asn Single submitter ⚠
- p.Gln216Arg Single submitter ⚠
- p.Ile23Thr Single submitter ⚠
- p.Ile23Val Single submitter ⚠
- p.Ile292Thr Single submitter ⚠
- p.Ile389Thr Single submitter ⚠
- p.Ile401Thr Single submitter ⚠
- p.Ile414Thr Single submitter ⚠
- p.Leu235Ile Single submitter
- p.Lys379Asn Single submitter ⚠
- p.Lys424Arg Single submitter ⚠
- p.Pro408Thr Single submitter ⚠
- p.Ser35Thr Single submitter ⚠
- p.Thr189Asn Single submitter ⚠
- p.Thr28Ile Single submitter ⚠
- p.Thr321Ile Single submitter ⚠
- p.Thr432Lys Single submitter ⚠
- p.Val133Ile Single submitter ⚠
- p.Val225Ala Single submitter ⚠
- p.Val281Ile Single submitter ⚠
- p.Val64Ala Single submitter ⚠