GPR27 — 50 ClinVar variants
All ClinVar germline GPR27 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 48 flagged for review →
50 Uncertain significance
Full GPR27 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 48
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 42
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- GPR27 p.Ala140Thr Uncertain significance Single submitter
- GPR27 p.Ala147Ser Uncertain significance Single submitter
- GPR27 p.Ala151Glu Uncertain significance Single submitter
- GPR27 p.Ala154Thr Uncertain significance Single submitter
- GPR27 p.Ala15Val Uncertain significance Single submitter
- GPR27 p.Ala169Thr Uncertain significance Single submitter
- GPR27 p.Ala172Thr Uncertain significance Single submitter
- GPR27 p.Ala180Asp Uncertain significance Single submitter
- GPR27 p.Ala180Thr Uncertain significance Single submitter
- GPR27 p.Ala303Thr Uncertain significance Single submitter
- GPR27 p.Ala364Val Uncertain significance Single submitter
- GPR27 p.Ala68Thr Uncertain significance Single submitter
- GPR27 p.Ala78Thr Uncertain significance Single submitter
- GPR27 p.Ala84Ser Uncertain significance Single submitter
- GPR27 p.Arg259Gly Uncertain significance Single submitter
- GPR27 p.Asp165Glu Uncertain significance Single submitter
- GPR27 p.Cys171Tyr Uncertain significance Single submitter
- GPR27 p.Cys356Trp Uncertain significance Single submitter
- GPR27 p.Glu344Gln Uncertain significance Single submitter
- GPR27 p.Glu46Lys Uncertain significance Single submitter
- GPR27 p.Glu6Asp Uncertain significance Single submitter
- GPR27 p.His225Gln Uncertain significance Single submitter
- GPR27 p.His366Tyr Uncertain significance Single submitter
- GPR27 p.Ile333Leu Uncertain significance Single submitter
- GPR27 p.Leu219Pro Uncertain significance Single submitter
- GPR27 p.Leu292Val Uncertain significance Single submitter
- GPR27 p.Pro170Gln Uncertain significance Single submitter
- GPR27 p.Pro177His Uncertain significance Single submitter
- GPR27 p.Pro354Ser Uncertain significance Single submitter
- GPR27 p.Pro7Leu Uncertain significance Single submitter
- GPR27 p.Pro7Ser Uncertain significance Single submitter
- GPR27 p.Pro90Ala Uncertain significance Single submitter
- GPR27 p.Ser358Ile Uncertain significance Single submitter
- GPR27 p.Thr278Arg Uncertain significance Single submitter
- GPR27 p.Thr321Met Uncertain significance Single submitter
- GPR27 p.Thr361Ile Uncertain significance Single submitter
- GPR27 p.Val192Gly Uncertain significance Single submitter
- GPR27 p.Val194Ala Uncertain significance Single submitter
- GPR27 p.Val200Leu Uncertain significance Single submitter
- GPR27 p.Val301Ile Uncertain significance Single submitter
- GPR27 p.Val302Leu Uncertain significance Single submitter
- GPR27 p.Val44Leu Uncertain significance Single submitter
Predictors split 6
The independent predictors disagree with each other — read with care.
- GPR27 p.Arg211Leu Uncertain significance Single submitter
- GPR27 p.Asn334Thr Uncertain significance Single submitter
- GPR27 p.Gly231Ser Uncertain significance Single submitter
- GPR27 p.Leu255Arg Uncertain significance Single submitter
- GPR27 p.Leu27Arg Uncertain significance Single submitter
- GPR27 p.Pro90Gln Uncertain significance Single submitter
All GPR27 variants
Uncertain significance 50
- p.Ala140Thr Single submitter ⚠
- p.Ala147Ser Single submitter ⚠
- p.Ala151Glu Single submitter ⚠
- p.Ala154Thr Single submitter ⚠
- p.Ala15Val Single submitter ⚠
- p.Ala169Thr Single submitter ⚠
- p.Ala172Thr Single submitter ⚠
- p.Ala180Asp Single submitter ⚠
- p.Ala180Thr Single submitter ⚠
- p.Ala240Thr Single submitter
- p.Ala303Thr Single submitter ⚠
- p.Ala364Val Single submitter ⚠
- p.Ala68Thr Single submitter ⚠
- p.Ala78Thr Single submitter ⚠
- p.Ala84Ser Single submitter ⚠
- p.Arg211Leu Single submitter ⚠
- p.Arg248Gly Single submitter
- p.Arg259Gly Single submitter ⚠
- p.Asn334Thr Single submitter ⚠
- p.Asp165Glu Single submitter ⚠
- p.Cys171Tyr Single submitter ⚠
- p.Cys356Trp Single submitter ⚠
- p.Glu344Gln Single submitter ⚠
- p.Glu46Lys Single submitter ⚠
- p.Glu6Asp Single submitter ⚠
- p.Gly231Ser Single submitter ⚠
- p.His225Gln Single submitter ⚠
- p.His366Tyr Single submitter ⚠
- p.Ile333Leu Single submitter ⚠
- p.Leu219Pro Single submitter ⚠
- p.Leu255Arg Single submitter ⚠
- p.Leu27Arg Single submitter ⚠
- p.Leu292Val Single submitter ⚠
- p.Pro170Gln Single submitter ⚠
- p.Pro177His Single submitter ⚠
- p.Pro354Ser Single submitter ⚠
- p.Pro7Leu Single submitter ⚠
- p.Pro7Ser Single submitter ⚠
- p.Pro90Ala Single submitter ⚠
- p.Pro90Gln Single submitter ⚠
- p.Ser358Ile Single submitter ⚠
- p.Thr278Arg Single submitter ⚠
- p.Thr321Met Single submitter ⚠
- p.Thr361Ile Single submitter ⚠
- p.Val192Gly Single submitter ⚠
- p.Val194Ala Single submitter ⚠
- p.Val200Leu Single submitter ⚠
- p.Val301Ile Single submitter ⚠
- p.Val302Leu Single submitter ⚠
- p.Val44Leu Single submitter ⚠