GPR3 — 34 ClinVar variants
All ClinVar germline GPR3 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 33 flagged for review →
1 Likely benign · 33 Uncertain significance
Full GPR3 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 33
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 28
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- GPR3 p.Ala106Val Uncertain significance Single submitter
- GPR3 p.Ala10Ser Uncertain significance Single submitter
- GPR3 p.Ala236Ser Uncertain significance Single submitter
- GPR3 p.Ala35Thr Uncertain significance Single submitter
- GPR3 p.Ala42Val Uncertain significance Single submitter
- GPR3 p.Arg134Cys Uncertain significance Single submitter
- GPR3 p.Arg152Gln Uncertain significance Single submitter
- GPR3 p.Arg231Trp Uncertain significance Single submitter
- GPR3 p.Arg243His Uncertain significance Single submitter
- GPR3 p.Arg323Gln Uncertain significance Single submitter
- GPR3 p.Glu147Ala Uncertain significance Single submitter
- GPR3 p.Gly125Ser Uncertain significance Single submitter
- GPR3 p.Gly163Val Uncertain significance Single submitter
- GPR3 p.Ile103Leu Uncertain significance Single submitter
- GPR3 p.Ile208Val Uncertain significance Single submitter
- GPR3 p.Ile292Asn Uncertain significance Single submitter
- GPR3 p.Met75Thr Uncertain significance Single submitter
- GPR3 p.Phe101Tyr Uncertain significance Single submitter
- GPR3 p.Pro33Leu Uncertain significance Single submitter
- GPR3 p.Pro36Leu Uncertain significance Single submitter
- GPR3 p.Thr149Ala Uncertain significance Single submitter
- GPR3 p.Trp309Cys Uncertain significance Single submitter
- GPR3 p.Tyr213Cys Uncertain significance Single submitter
- GPR3 p.Tyr239Cys Uncertain significance Single submitter
- GPR3 p.Tyr280Cys Uncertain significance Single submitter
- GPR3 p.Val19Met Uncertain significance Single submitter
- GPR3 p.Val61Ala Uncertain significance Single submitter
- GPR3 p.Val84Met Uncertain significance Single submitter
Predictors split 5
The independent predictors disagree with each other — read with care.
All GPR3 variants
Likely benign 1
- p.Pro26Ser Single submitter
Uncertain significance 33
- p.Ala106Val Single submitter ⚠
- p.Ala10Ser Single submitter ⚠
- p.Ala236Ser Single submitter ⚠
- p.Ala35Thr Single submitter ⚠
- p.Ala42Val Single submitter ⚠
- p.Arg134Cys Single submitter ⚠
- p.Arg152Gln Single submitter ⚠
- p.Arg152Trp Single submitter ⚠
- p.Arg231Trp Single submitter ⚠
- p.Arg243His Single submitter ⚠
- p.Arg323Gln Single submitter ⚠
- p.Cys56Tyr Single submitter ⚠
- p.Glu147Ala Single submitter ⚠
- p.Gly125Ser Single submitter ⚠
- p.Gly163Val Single submitter ⚠
- p.Gly245Ser Single submitter ⚠
- p.Ile103Leu Single submitter ⚠
- p.Ile208Val Single submitter ⚠
- p.Ile292Asn Single submitter ⚠
- p.Met75Thr Single submitter ⚠
- p.Phe101Tyr Single submitter ⚠
- p.Pro33Leu Single submitter ⚠
- p.Pro36Leu Single submitter ⚠
- p.Ser328Arg Single submitter ⚠
- p.Thr149Ala Single submitter ⚠
- p.Trp309Cys Single submitter ⚠
- p.Tyr213Cys Single submitter ⚠
- p.Tyr239Cys Single submitter ⚠
- p.Tyr280Cys Single submitter ⚠
- p.Val19Met Single submitter ⚠
- p.Val304Ala Single submitter ⚠
- p.Val61Ala Single submitter ⚠
- p.Val84Met Single submitter ⚠