GPR34 — 14 ClinVar variants

All ClinVar germline GPR34 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 10 flagged for review →

1 Benign · 1 Benign/Likely benign · 2 Likely benign · 10 Uncertain significance

Full GPR34 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions

⚑ Evidence disagreements 10

Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.

Predictors lean, ClinVar uncertain 10

ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.

All GPR34 variants

Benign 1

p.Val296= Multiple submitters

Benign/Likely benign 1

p.Asn295Ser Multiple submitters

Likely benign 2

p.Ile191Val Single submitter
p.Ile337Val Single submitter

Uncertain significance 10

p.Arg266Cys Single submitter ⚠
p.Arg352Lys Single submitter ⚠
p.Asn200Ser Single submitter ⚠
p.Asp49Gly Single submitter ⚠
p.Gly198Arg Single submitter ⚠
p.Met112Thr Single submitter ⚠
p.Ser171Asn Single submitter ⚠
p.Ser332Gly Single submitter ⚠
p.Ser3Asn Single submitter ⚠
p.Val96Ile Single submitter ⚠