GPR35 — 82 ClinVar variants

All ClinVar germline GPR35 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 53 flagged for review →

9 Benign · 4 Benign/Likely benign · 13 Likely benign · 56 Uncertain significance

Full GPR35 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions

⚑ Evidence disagreements 53

Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.

Predictors lean, ClinVar uncertain 40

ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.

Predictors split 13

The independent predictors disagree with each other — read with care.

All GPR35 variants

Benign 9

p.Ala25Thr Multiple submitters
p.Ala41= Multiple submitters
p.Arg56Cys Multiple submitters ⚠
p.Asn246= Multiple submitters
p.Gly126Arg Multiple submitters
p.Gly159= Multiple submitters
p.Thr108Met Multiple submitters ⚠
p.Val29Ile Multiple submitters
p.Val76Met Multiple submitters

Benign/Likely benign 4

p.Ala286= Multiple submitters
p.Arg100= Multiple submitters
p.Asn222= Multiple submitters
p.Phe226= Multiple submitters

Likely benign 13

p.Asn169Asp Multiple submitters
p.Ala185= Single submitter
p.Cys305Ser Single submitter
p.Gly146Ser Single submitter
p.Ile145Val Single submitter
p.Leu27Ser Single submitter
p.Pro87Leu Single submitter
p.Ser11= Single submitter
p.Ser11Gly Single submitter
p.Ser39Gly Single submitter
p.Thr53= Single submitter
p.Thr86= Single submitter
p.Tyr5Cys Single submitter

Uncertain significance 56

p.Ala134Val Single submitter ⚠
p.Ala138Thr Single submitter ⚠
p.Ala197Thr Single submitter ⚠
p.Ala242Thr Single submitter ⚠
p.Ala273Val Single submitter
p.Ala290Gly Single submitter ⚠
p.Ala63Val Single submitter ⚠
p.Ala65Ser Single submitter ⚠
p.Arg123Cys Single submitter ⚠
p.Arg123His Single submitter ⚠
p.Arg128Gln Single submitter
p.Arg128Trp Single submitter
p.Arg164Gly Single submitter ⚠
p.Arg167Gln Single submitter ⚠
p.Arg167Trp Single submitter ⚠
p.Arg217Cys Single submitter ⚠
p.Arg217His Single submitter ⚠
p.Arg240Cys Single submitter ⚠
p.Arg240Leu Single submitter ⚠
p.Arg240Ser Single submitter ⚠
p.Arg255His Single submitter ⚠
p.Arg256Cys Single submitter ⚠
p.Arg256His Single submitter ⚠
p.Asn268Lys Single submitter ⚠
p.Asn6Thr Single submitter ⚠
p.Asp12Asn Single submitter ⚠
p.Asp205Asn Single submitter ⚠
p.Cys68Ser Single submitter ⚠
p.Gly34Ser Single submitter ⚠
p.Gly34Val Single submitter ⚠
p.Ile104Met Single submitter
p.Ile260Val Single submitter ⚠
p.Leu233Pro Single submitter ⚠
p.Leu67Pro Single submitter ⚠
p.Leu80Pro Single submitter ⚠
p.Phe189Val Single submitter ⚠
p.Pro121Gln Single submitter ⚠
p.Pro121Leu Single submitter ⚠
p.Pro176Leu Single submitter ⚠
p.Ser165Gly Single submitter ⚠
p.Ser191Phe Single submitter ⚠
p.Ser294Asn Single submitter ⚠
p.Ser300Gly Single submitter ⚠
p.Ser92Phe Single submitter ⚠
p.Thr86Met Single submitter ⚠
p.Tyr24Cys Single submitter ⚠
p.Tyr26Phe Single submitter ⚠
p.Tyr96Phe Single submitter ⚠
p.Val112Met Single submitter ⚠
p.Val118Met Single submitter
p.Val136Met Single submitter ⚠
p.Val186Met Single submitter ⚠
p.Val195Ala Single submitter ⚠
p.Val195Leu Single submitter ⚠
p.Val235Leu Single submitter ⚠
p.Val306Glu Single submitter ⚠