GPR4 — 41 ClinVar variants
All ClinVar germline GPR4 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 39 flagged for review →
1 Likely benign · 40 Uncertain significance
Full GPR4 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 39
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 25
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- GPR4 p.Ala195Thr Uncertain significance Single submitter
- GPR4 p.Ala195Val Uncertain significance Single submitter
- GPR4 p.Ala231Val Uncertain significance Single submitter
- GPR4 p.Ala293Thr Uncertain significance Single submitter
- GPR4 p.Arg216Leu Uncertain significance Single submitter
- GPR4 p.Arg254His Uncertain significance Single submitter
- GPR4 p.Arg306Cys Uncertain significance Single submitter
- GPR4 p.Asp296Glu Uncertain significance Single submitter
- GPR4 p.Gly189Asp Uncertain significance Single submitter
- GPR4 p.Ile103Val Uncertain significance Single submitter
- GPR4 p.Leu191Val Uncertain significance Single submitter
- GPR4 p.Leu272Pro Uncertain significance Single submitter
- GPR4 p.Leu321Ile Uncertain significance Single submitter
- GPR4 p.Met338Leu Uncertain significance Single submitter
- GPR4 p.Phe265Cys Uncertain significance Single submitter
- GPR4 p.Pro359Leu Uncertain significance Single submitter
- GPR4 p.Pro359Ser Uncertain significance Single submitter
- GPR4 p.Ser138Thr Uncertain significance Single submitter
- GPR4 p.Ser295Arg Uncertain significance Single submitter
- GPR4 p.Ser89Thr Uncertain significance Single submitter
- GPR4 p.Thr144Lys Uncertain significance Single submitter
- GPR4 p.Thr334Lys Uncertain significance Single submitter
- GPR4 p.Trp180Ser Uncertain significance Single submitter
- GPR4 p.Val188Leu Uncertain significance Single submitter
- GPR4 p.Val235Ile Uncertain significance Single submitter
Predictors split 14
The independent predictors disagree with each other — read with care.
- GPR4 p.Arg263Cys Uncertain significance Single submitter
- GPR4 p.Arg44Cys Uncertain significance Single submitter
- GPR4 p.Arg44Ser Uncertain significance Single submitter
- GPR4 p.Arg49His Uncertain significance Single submitter
- GPR4 p.Asp296His Uncertain significance Single submitter
- GPR4 p.Gly86Ser Uncertain significance Single submitter
- GPR4 p.Pro313Ala Uncertain significance Single submitter
- GPR4 p.Ser211Arg Uncertain significance Single submitter
- GPR4 p.Ser341Asn Uncertain significance Single submitter
- GPR4 p.Val135Met Uncertain significance Single submitter
- GPR4 p.Val137Ala Uncertain significance Single submitter
- GPR4 p.Val208Leu Uncertain significance Single submitter
- GPR4 p.Val46Met Uncertain significance Single submitter
- GPR4 p.Val54Ile Uncertain significance Single submitter
All GPR4 variants
Likely benign 1
- p.Gln47Arg Single submitter
Uncertain significance 40
- p.Ala195Thr Single submitter ⚠
- p.Ala195Val Single submitter ⚠
- p.Ala231Val Single submitter ⚠
- p.Ala293Thr Single submitter ⚠
- p.Arg216Leu Single submitter ⚠
- p.Arg254His Single submitter ⚠
- p.Arg263Cys Single submitter ⚠
- p.Arg306Cys Single submitter ⚠
- p.Arg44Cys Single submitter ⚠
- p.Arg44Ser Single submitter ⚠
- p.Arg49His Single submitter ⚠
- p.Asp296Glu Single submitter ⚠
- p.Asp296His Single submitter ⚠
- p.Gly189Asp Single submitter ⚠
- p.Gly2_Asn3insLys Single submitter
- p.Gly86Ser Single submitter ⚠
- p.Ile103Val Single submitter ⚠
- p.Leu191Val Single submitter ⚠
- p.Leu272Pro Single submitter ⚠
- p.Leu321Ile Single submitter ⚠
- p.Met338Leu Single submitter ⚠
- p.Phe265Cys Single submitter ⚠
- p.Pro313Ala Single submitter ⚠
- p.Pro359Leu Single submitter ⚠
- p.Pro359Ser Single submitter ⚠
- p.Ser138Thr Single submitter ⚠
- p.Ser211Arg Single submitter ⚠
- p.Ser295Arg Single submitter ⚠
- p.Ser341Asn Single submitter ⚠
- p.Ser89Thr Single submitter ⚠
- p.Thr144Lys Single submitter ⚠
- p.Thr334Lys Single submitter ⚠
- p.Trp180Ser Single submitter ⚠
- p.Val135Met Single submitter ⚠
- p.Val137Ala Single submitter ⚠
- p.Val188Leu Single submitter ⚠
- p.Val208Leu Single submitter ⚠
- p.Val235Ile Single submitter ⚠
- p.Val46Met Single submitter ⚠
- p.Val54Ile Single submitter ⚠