GPR52 — 41 ClinVar variants
All ClinVar germline GPR52 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 36 flagged for review →
1 Benign · 1 Likely benign · 39 Uncertain significance
Full GPR52 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 36
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 30
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- GPR52 p.Ala84Pro Uncertain significance Single submitter
- GPR52 p.Arg139His Uncertain significance Single submitter
- GPR52 p.Arg157Pro Uncertain significance Single submitter
- GPR52 p.Arg325Gln Uncertain significance Single submitter
- GPR52 p.Arg325Trp Uncertain significance Single submitter
- GPR52 p.Arg5Gly Uncertain significance Single submitter
- GPR52 p.Arg5Lys Uncertain significance Single submitter
- GPR52 p.Asp250Ala Uncertain significance Single submitter
- GPR52 p.Cys156Ser Uncertain significance Single submitter
- GPR52 p.Cys170Ser Uncertain significance Single submitter
- GPR52 p.Cys336Ser Uncertain significance Single submitter
- GPR52 p.Glu254Asp Uncertain significance Single submitter
- GPR52 p.His33Asp Uncertain significance Single submitter
- GPR52 p.Ile120Val Uncertain significance Single submitter
- GPR52 p.Ile361Val Uncertain significance Single submitter
- GPR52 p.Pro214Ala Uncertain significance Single submitter
- GPR52 p.Pro28Ser Uncertain significance Single submitter
- GPR52 p.Ser105Phe Uncertain significance Single submitter
- GPR52 p.Ser258Asn Uncertain significance Single submitter
- GPR52 p.Ser258Ile Uncertain significance Single submitter
- GPR52 p.Ser338Thr Uncertain significance Single submitter
- GPR52 p.Thr195Met Uncertain significance Single submitter
- GPR52 p.Thr234Ile Uncertain significance Single submitter
- GPR52 p.Thr297Ser Uncertain significance Single submitter
- GPR52 p.Thr334Lys Uncertain significance Single submitter
- GPR52 p.Tyr149Cys Uncertain significance Single submitter
- GPR52 p.Tyr78Cys Uncertain significance Single submitter
- GPR52 p.Val123Phe Uncertain significance Single submitter
- GPR52 p.Val46Ile Uncertain significance Single submitter
- GPR52 p.Val48Met Uncertain significance Single submitter
Predictors split 6
The independent predictors disagree with each other — read with care.
- GPR52 p.Ala264Thr Uncertain significance Single submitter
- GPR52 p.Cys314Tyr Uncertain significance Single submitter
- GPR52 p.Ile135Leu Uncertain significance Single submitter
- GPR52 p.Leu158Phe Uncertain significance Single submitter
- GPR52 p.Ser338Pro Uncertain significance Single submitter
- GPR52 p.Val273Leu Uncertain significance Single submitter
All GPR52 variants
Benign 1
- p.Arg355Trp Multiple submitters
Likely benign 1
- p.Gln348Arg Single submitter
Uncertain significance 39
- p.Ala264Thr Single submitter ⚠
- p.Ala84Pro Single submitter ⚠
- p.Arg139His Single submitter ⚠
- p.Arg157Pro Single submitter ⚠
- p.Arg261Cys Single submitter
- p.Arg262Cys Single submitter
- p.Arg325Gln Single submitter ⚠
- p.Arg325Trp Single submitter ⚠
- p.Arg5Gly Single submitter ⚠
- p.Arg5Lys Single submitter ⚠
- p.Asp250Ala Single submitter ⚠
- p.Cys156Ser Single submitter ⚠
- p.Cys170Ser Single submitter ⚠
- p.Cys314Tyr Single submitter ⚠
- p.Cys336Ser Single submitter ⚠
- p.Glu254Asp Single submitter ⚠
- p.His33Asp Single submitter ⚠
- p.Ile120Val Single submitter ⚠
- p.Ile135Leu Single submitter ⚠
- p.Ile361Val Single submitter ⚠
- p.Leu158Phe Single submitter ⚠
- p.Pro214Ala Single submitter ⚠
- p.Pro28Ser Single submitter ⚠
- p.Ser105Phe Single submitter ⚠
- p.Ser258Asn Single submitter ⚠
- p.Ser258Ile Single submitter ⚠
- p.Ser338Pro Single submitter ⚠
- p.Ser338Thr Single submitter ⚠
- p.Thr195Met Single submitter ⚠
- p.Thr234Ile Single submitter ⚠
- p.Thr297Ser Single submitter ⚠
- p.Thr334Lys Single submitter ⚠
- p.Tyr149Cys Single submitter ⚠
- p.Tyr78Cys Single submitter ⚠
- p.Val123Ala Single submitter
- p.Val123Phe Single submitter ⚠
- p.Val273Leu Single submitter ⚠
- p.Val46Ile Single submitter ⚠
- p.Val48Met Single submitter ⚠