GPR55 — 52 ClinVar variants
All ClinVar germline GPR55 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 46 flagged for review →
1 Benign · 3 Likely benign · 48 Uncertain significance
Full GPR55 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 46
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 41
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- GPR55 p.Ala179Val Uncertain significance Single submitter
- GPR55 p.Ala223Gly Uncertain significance Single submitter
- GPR55 p.Ala223Val Uncertain significance Single submitter
- GPR55 p.Ala25Val Uncertain significance Single submitter
- GPR55 p.Ala67Ser Uncertain significance Single submitter
- GPR55 p.Arg124His Uncertain significance Single submitter
- GPR55 p.Arg133Gln Uncertain significance Single submitter
- GPR55 p.Arg133Trp Uncertain significance Single submitter
- GPR55 p.Arg211His Uncertain significance Single submitter
- GPR55 p.Arg212Gln Uncertain significance Single submitter
- GPR55 p.Arg296His Uncertain significance Single submitter
- GPR55 p.Arg303Gln Uncertain significance Single submitter
- GPR55 p.Arg318Trp Uncertain significance Single submitter
- GPR55 p.Asn254Ser Uncertain significance Single submitter
- GPR55 p.Asp313His Uncertain significance Single submitter
- GPR55 p.Asp9Gly Uncertain significance Single submitter
- GPR55 p.Gly107Arg Uncertain significance Single submitter
- GPR55 p.Gly14Val Uncertain significance Single submitter
- GPR55 p.Gly152Arg Uncertain significance Single submitter
- GPR55 p.Gly189Asp Uncertain significance Single submitter
- GPR55 p.His243Tyr Uncertain significance Single submitter
- GPR55 p.His43Leu Uncertain significance Single submitter
- GPR55 p.Ile42Met Uncertain significance Single submitter
- GPR55 p.Leu191Phe Uncertain significance Single submitter
- GPR55 p.Leu248Gln Uncertain significance Single submitter
- GPR55 p.Leu37Val Uncertain significance Single submitter
- GPR55 p.Met167Ile Uncertain significance Single submitter
- GPR55 p.Met63Arg Uncertain significance Single submitter
- GPR55 p.Pro126Ser Uncertain significance Single submitter
- GPR55 p.Pro155Ser Uncertain significance Single submitter
- GPR55 p.Ser108Asn Uncertain significance Single submitter
- GPR55 p.Ser130Ile Uncertain significance Single submitter
- GPR55 p.Ser88Thr Uncertain significance Single submitter
- GPR55 p.Thr314Ala Uncertain significance Single submitter
- GPR55 p.Val163Leu Uncertain significance Single submitter
- GPR55 p.Val219Met Uncertain significance Single submitter
- GPR55 p.Val236Met Uncertain significance Single submitter
- GPR55 p.Val258Ala Uncertain significance Single submitter
- GPR55 p.Val32Ala Uncertain significance Single submitter
- GPR55 p.Val32Ile Uncertain significance Single submitter
-
GPR55 p.Thr314Ile
Uncertain significance
No assertion criteria
prostate cancer
Predictors split 5
The independent predictors disagree with each other — read with care.
All GPR55 variants
Benign 1
- p.Val103Ile Multiple submitters
Likely benign 3
- p.Met274Leu Single submitter
- p.Thr315Met Single submitter
- p.Val279Ile Single submitter
Uncertain significance 48
- p.Ala179Val Single submitter ⚠
- p.Ala223Gly Single submitter ⚠
- p.Ala223Val Single submitter ⚠
- p.Ala25Val Single submitter ⚠
- p.Ala67Ser Single submitter ⚠
- p.Arg124His Single submitter ⚠
- p.Arg133Gln Single submitter ⚠
- p.Arg133Trp Single submitter ⚠
- p.Arg211His Single submitter ⚠
- p.Arg212Gln Single submitter ⚠
- p.Arg296Cys Single submitter ⚠
- p.Arg296His Single submitter ⚠
- p.Arg303Gln Single submitter ⚠
- p.Arg318Trp Single submitter ⚠
- p.Asn254Ser Single submitter ⚠
- p.Asn278Asp Single submitter ⚠
- p.Asp313His Single submitter ⚠
- p.Asp9Gly Single submitter ⚠
- p.Cys281Ser Single submitter
- p.Gln249Lys Single submitter
- p.Gly107Arg Single submitter ⚠
- p.Gly14Val Single submitter ⚠
- p.Gly152Arg Single submitter ⚠
- p.Gly189Asp Single submitter ⚠
- p.His243Tyr Single submitter ⚠
- p.His43Leu Single submitter ⚠
- p.Ile42Met Single submitter ⚠
- p.Leu191Phe Single submitter ⚠
- p.Leu248Gln Single submitter ⚠
- p.Leu37Val Single submitter ⚠
- p.Leu40Arg Single submitter ⚠
- p.Met167Ile Single submitter ⚠
- p.Met63Arg Single submitter ⚠
- p.Pro126Ser Single submitter ⚠
- p.Pro155Ser Single submitter ⚠
- p.Pro184Leu Single submitter ⚠
- p.Ser108Asn Single submitter ⚠
- p.Ser116Asn Single submitter ⚠
- p.Ser130Ile Single submitter ⚠
- p.Ser88Thr Single submitter ⚠
- p.Thr314Ala Single submitter ⚠
- p.Val163Leu Single submitter ⚠
- p.Val219Met Single submitter ⚠
- p.Val236Met Single submitter ⚠
- p.Val258Ala Single submitter ⚠
- p.Val32Ala Single submitter ⚠
- p.Val32Ile Single submitter ⚠
- p.Thr314Ile No assertion criteria prostate cancer ⚠