GPR6 — 50 ClinVar variants
All ClinVar germline GPR6 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 46 flagged for review →
2 Benign · 1 Likely benign · 47 Uncertain significance
Full GPR6 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 46
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 42
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- GPR6 p.Ala121Glu Uncertain significance Single submitter
- GPR6 p.Ala153Ser Uncertain significance Single submitter
- GPR6 p.Ala214Ser Uncertain significance Single submitter
- GPR6 p.Ala232Thr Uncertain significance Single submitter
- GPR6 p.Ala260Thr Uncertain significance Single submitter
- GPR6 p.Ala308Thr Uncertain significance Single submitter
- GPR6 p.Ala71Val Uncertain significance Single submitter
- GPR6 p.Ala91Thr Uncertain significance Single submitter
- GPR6 p.Ala95Thr Uncertain significance Single submitter
- GPR6 p.Ala95Val Uncertain significance Single submitter
- GPR6 p.Asn321Ser Uncertain significance Single submitter
- GPR6 p.Asn333Ser Uncertain significance Single submitter
- GPR6 p.Asn9His Uncertain significance Single submitter
- GPR6 p.Asp10Asn Uncertain significance Single submitter
- GPR6 p.Asp165Ala Uncertain significance Single submitter
- GPR6 p.Asp76Val Uncertain significance Single submitter
- GPR6 p.Cys265Ser Uncertain significance Single submitter
- GPR6 p.Gly206Ser Uncertain significance Single submitter
- GPR6 p.Gly29Ala Uncertain significance Single submitter
- GPR6 p.His186Tyr Uncertain significance Single submitter
- GPR6 p.His243Arg Uncertain significance Single submitter
- GPR6 p.His304Asn Uncertain significance Single submitter
- GPR6 p.Leu182Pro Uncertain significance Single submitter
- GPR6 p.Leu44Pro Uncertain significance Single submitter
- GPR6 p.Leu67Phe Uncertain significance Single submitter
- GPR6 p.Leu69Arg Uncertain significance Single submitter
- GPR6 p.Met323Val Uncertain significance Single submitter
- GPR6 p.Pro136Ser Uncertain significance Single submitter
- GPR6 p.Pro38Thr Uncertain significance Single submitter
- GPR6 p.Ser141Asn Uncertain significance Single submitter
- GPR6 p.Ser225Asn Uncertain significance Single submitter
- GPR6 p.Ser358Pro Uncertain significance Single submitter
- GPR6 p.Ser358Thr Uncertain significance Single submitter
- GPR6 p.Ser53Phe Uncertain significance Single submitter
- GPR6 p.Ser61Leu Uncertain significance Single submitter
- GPR6 p.Val16Met Uncertain significance Single submitter
- GPR6 p.Val185Leu Uncertain significance Single submitter
- GPR6 p.Val237Leu Uncertain significance Single submitter
- GPR6 p.Val246Ala Uncertain significance Single submitter
- GPR6 p.Val246Leu Uncertain significance Single submitter
- GPR6 p.Val278Ala Uncertain significance Single submitter
- GPR6 p.Val300Met Uncertain significance Single submitter
Predictors split 4
The independent predictors disagree with each other — read with care.
All GPR6 variants
Benign 2
- c.-18-9C>T Single submitter
- p.Ala173= Single submitter
Likely benign 1
- p.Ala28Thr Single submitter
Uncertain significance 47
- p.Ala121Glu Single submitter ⚠
- p.Ala153Ser Single submitter ⚠
- p.Ala173Ser Single submitter ⚠
- p.Ala214Ser Single submitter ⚠
- p.Ala232Thr Single submitter ⚠
- p.Ala260Thr Single submitter ⚠
- p.Ala273Val Single submitter ⚠
- p.Ala308Thr Single submitter ⚠
- p.Ala71Val Single submitter ⚠
- p.Ala91Thr Single submitter ⚠
- p.Ala95Thr Single submitter ⚠
- p.Ala95Val Single submitter ⚠
- p.Arg332Gly Single submitter ⚠
- p.Asn321Ser Single submitter ⚠
- p.Asn333Ser Single submitter ⚠
- p.Asn9His Single submitter ⚠
- p.Asp10Asn Single submitter ⚠
- p.Asp165Ala Single submitter ⚠
- p.Asp76Val Single submitter ⚠
- p.Cys265Ser Single submitter ⚠
- p.Gly206Ser Single submitter ⚠
- p.Gly29Ala Single submitter ⚠
- p.His186Tyr Single submitter ⚠
- p.His243Arg Single submitter ⚠
- p.His304Asn Single submitter ⚠
- p.Leu182Pro Single submitter ⚠
- p.Leu244Met Single submitter
- p.Leu44Pro Single submitter ⚠
- p.Leu67Phe Single submitter ⚠
- p.Leu69Arg Single submitter ⚠
- p.Met323Val Single submitter ⚠
- p.Pro136Ser Single submitter ⚠
- p.Pro38Thr Single submitter ⚠
- p.Ser141Asn Single submitter ⚠
- p.Ser225Asn Single submitter ⚠
- p.Ser358Pro Single submitter ⚠
- p.Ser358Thr Single submitter ⚠
- p.Ser53Phe Single submitter ⚠
- p.Ser61Leu Single submitter ⚠
- p.Thr181Ala Single submitter ⚠
- p.Val16Met Single submitter ⚠
- p.Val185Leu Single submitter ⚠
- p.Val237Leu Single submitter ⚠
- p.Val246Ala Single submitter ⚠
- p.Val246Leu Single submitter ⚠
- p.Val278Ala Single submitter ⚠
- p.Val300Met Single submitter ⚠