GPR65 — 35 ClinVar variants
All ClinVar germline GPR65 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 29 flagged for review →
1 Benign · 3 Likely benign · 31 Uncertain significance
Full GPR65 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 29
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 26
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- GPR65 p.Ala109Thr Uncertain significance Single submitter
- GPR65 p.Arg129Thr Uncertain significance Single submitter
- GPR65 p.Arg204Trp Uncertain significance Single submitter
- GPR65 p.Arg319Lys Uncertain significance Single submitter
- GPR65 p.Asn166Tyr Uncertain significance Single submitter
- GPR65 p.Gln9Arg Uncertain significance Single submitter
- GPR65 p.Glu163Val Uncertain significance Single submitter
- GPR65 p.Ile26Thr Uncertain significance Single submitter
- GPR65 p.Ile29Met Uncertain significance Single submitter
- GPR65 p.Ile71Val Uncertain significance Single submitter
- GPR65 p.Leu141Ser Uncertain significance Single submitter
- GPR65 p.Leu36Pro Uncertain significance Single submitter
- GPR65 p.Lys219Arg Uncertain significance Single submitter
- GPR65 p.Lys320Asn Uncertain significance Single submitter
- GPR65 p.Met245Val Uncertain significance Single submitter
- GPR65 p.Met271Thr Uncertain significance Single submitter
- GPR65 p.Met301Thr Uncertain significance Single submitter
- GPR65 p.Met96Val Uncertain significance Single submitter
- GPR65 p.Phe124Ser Uncertain significance Single submitter
- GPR65 p.Pro84Thr Uncertain significance Single submitter
- GPR65 p.Ser135Asn Uncertain significance Single submitter
- GPR65 p.Ser59Ala Uncertain significance Single submitter
- GPR65 p.Tyr63Asp Uncertain significance Single submitter
- GPR65 p.Val156Ile Uncertain significance Single submitter
- GPR65 p.Val157Ala Uncertain significance Single submitter
- GPR65 p.Val256Leu Uncertain significance Single submitter
Predictors split 3
The independent predictors disagree with each other — read with care.
All GPR65 variants
Benign 1
- p.Thr74= Single submitter
Likely benign 3
- p.Arg267Gln Single submitter
- p.Glu259Lys Single submitter
- p.Ile194Val Single submitter
Uncertain significance 31
- p.Ala109Thr Single submitter ⚠
- p.Ala115Gly Single submitter
- p.Ala215Val Single submitter ⚠
- p.Arg129Thr Single submitter ⚠
- p.Arg204Trp Single submitter ⚠
- p.Arg319Lys Single submitter ⚠
- p.Asn166Tyr Single submitter ⚠
- p.Cys5Arg Single submitter
- p.Gln9Arg Single submitter ⚠
- p.Glu163Val Single submitter ⚠
- p.Gly297Glu Single submitter ⚠
- p.Ile26Thr Single submitter ⚠
- p.Ile29Met Single submitter ⚠
- p.Ile71Val Single submitter ⚠
- p.Leu141Ser Single submitter ⚠
- p.Leu36Pro Single submitter ⚠
- p.Lys219Arg Single submitter ⚠
- p.Lys320Asn Single submitter ⚠
- p.Met245Val Single submitter ⚠
- p.Met271Thr Single submitter ⚠
- p.Met301Thr Single submitter ⚠
- p.Met96Val Single submitter ⚠
- p.Phe124Ser Single submitter ⚠
- p.Pro84Thr Single submitter ⚠
- p.Ser135Asn Single submitter ⚠
- p.Ser39Phe Single submitter ⚠
- p.Ser59Ala Single submitter ⚠
- p.Tyr63Asp Single submitter ⚠
- p.Val156Ile Single submitter ⚠
- p.Val157Ala Single submitter ⚠
- p.Val256Leu Single submitter ⚠