GPR82 — 37 ClinVar variants
All ClinVar germline GPR82 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 29 flagged for review →
8 Likely benign · 29 Uncertain significance
Full GPR82 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 29
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 26
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- GPR82 p.Ala67Thr Uncertain significance Single submitter
- GPR82 p.Asn189Ser Uncertain significance Single submitter
- GPR82 p.Cys133Arg Uncertain significance Single submitter
- GPR82 p.Cys88Arg Uncertain significance Single submitter
- GPR82 p.Gln148Arg Uncertain significance Single submitter
- GPR82 p.Gln9Lys Uncertain significance Single submitter
- GPR82 p.Glu129Gly Uncertain significance Single submitter
- GPR82 p.Gly182Arg Uncertain significance Single submitter
- GPR82 p.Gly78Ser Uncertain significance Single submitter
- GPR82 p.Ile205Thr Uncertain significance Single submitter
- GPR82 p.Ile20Thr Uncertain significance Single submitter
- GPR82 p.Ile231Val Uncertain significance Single submitter
- GPR82 p.Ile27Phe Uncertain significance Single submitter
- GPR82 p.Leu287Ser Uncertain significance Single submitter
- GPR82 p.Leu310Ile Uncertain significance Single submitter
- GPR82 p.Leu323Pro Uncertain significance Single submitter
- GPR82 p.Lys317Gln Uncertain significance Single submitter
- GPR82 p.Lys46Arg Uncertain significance Single submitter
- GPR82 p.Met71Val Uncertain significance Single submitter
- GPR82 p.Pro10Ser Uncertain significance Single submitter
- GPR82 p.Thr130Ile Uncertain significance Single submitter
- GPR82 p.Thr235Pro Uncertain significance Single submitter
- GPR82 p.Trp160Leu Uncertain significance Single submitter
- GPR82 p.Tyr173His Uncertain significance Single submitter
- GPR82 p.Val28Ala Uncertain significance Single submitter
-
GPR82 p.Gly161Val
Uncertain significance
No assertion criteria
prostate cancer
Predictors split 3
The independent predictors disagree with each other — read with care.
All GPR82 variants
Likely benign 8
- p.Ser185Asn Multiple submitters
- p.Cys133= Single submitter
- p.Cys88= Single submitter
- p.Ile201Thr Single submitter
- p.Ser226Arg Single submitter
- p.Thr34Ser Single submitter
- p.Val170= Single submitter
- p.Val172Ile Single submitter
Uncertain significance 29
- p.Ala67Thr Single submitter ⚠
- p.Asn189Ser Single submitter ⚠
- p.Asn292Lys Single submitter ⚠
- p.Cys133Arg Single submitter ⚠
- p.Cys88Arg Single submitter ⚠
- p.Gln148Arg Single submitter ⚠
- p.Gln9Lys Single submitter ⚠
- p.Glu129Gly Single submitter ⚠
- p.Gly165Asp Single submitter ⚠
- p.Gly182Arg Single submitter ⚠
- p.Gly78Ser Single submitter ⚠
- p.Ile205Thr Single submitter ⚠
- p.Ile20Thr Single submitter ⚠
- p.Ile231Val Single submitter ⚠
- p.Ile27Phe Single submitter ⚠
- p.Leu287Ser Single submitter ⚠
- p.Leu310Ile Single submitter ⚠
- p.Leu323Pro Single submitter ⚠
- p.Lys317Gln Single submitter ⚠
- p.Lys46Arg Single submitter ⚠
- p.Met71Val Single submitter ⚠
- p.Phe104Leu Single submitter ⚠
- p.Pro10Ser Single submitter ⚠
- p.Thr130Ile Single submitter ⚠
- p.Thr235Pro Single submitter ⚠
- p.Trp160Leu Single submitter ⚠
- p.Tyr173His Single submitter ⚠
- p.Val28Ala Single submitter ⚠
- p.Gly161Val No assertion criteria prostate cancer ⚠