GPR84 — 44 ClinVar variants
All ClinVar germline GPR84 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 43 flagged for review →
2 Likely benign · 42 Uncertain significance
Full GPR84 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 43
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 36
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- GPR84 p.Ala208Val Uncertain significance Single submitter
- GPR84 p.Ala220Thr Uncertain significance Single submitter
- GPR84 p.Ala304Thr Uncertain significance Single submitter
- GPR84 p.Arg172Cys Uncertain significance Single submitter
- GPR84 p.Arg176Trp Uncertain significance Single submitter
- GPR84 p.Arg203Cys Uncertain significance Single submitter
- GPR84 p.Arg203His Uncertain significance Single submitter
- GPR84 p.Arg207Gln Uncertain significance Single submitter
- GPR84 p.Arg218Gln Uncertain significance Single submitter
- GPR84 p.Arg237Cys Uncertain significance Single submitter
- GPR84 p.Arg305Thr Uncertain significance Single submitter
- GPR84 p.Arg349Trp Uncertain significance Single submitter
- GPR84 p.Asp242His Uncertain significance Single submitter
- GPR84 p.Asp66Tyr Uncertain significance Single submitter
- GPR84 p.Gly18Asp Uncertain significance Single submitter
- GPR84 p.Gly190Arg Uncertain significance Single submitter
- GPR84 p.Gly248Ala Uncertain significance Single submitter
- GPR84 p.Gly248Glu Uncertain significance Single submitter
- GPR84 p.Gly315Glu Uncertain significance Single submitter
- GPR84 p.His124Gln Uncertain significance Single submitter
- GPR84 p.His85Tyr Uncertain significance Single submitter
- GPR84 p.Ile254Thr Uncertain significance Single submitter
- GPR84 p.Leu337Pro Uncertain significance Single submitter
- GPR84 p.Leu58Phe Uncertain significance Single submitter
- GPR84 p.Leu62Phe Uncertain significance Single submitter
- GPR84 p.Lys216Gln Uncertain significance Single submitter
- GPR84 p.Lys316Glu Uncertain significance Single submitter
- GPR84 p.Pro291Ala Uncertain significance Single submitter
- GPR84 p.Pro348Ser Uncertain significance Single submitter
- GPR84 p.Ser192Gly Uncertain significance Single submitter
- GPR84 p.Ser193Gly Uncertain significance Single submitter
- GPR84 p.Ser251Ile Uncertain significance Single submitter
- GPR84 p.Thr63Lys Uncertain significance Single submitter
- GPR84 p.Val164Ile Uncertain significance Single submitter
- GPR84 p.Val28Gly Uncertain significance Single submitter
- GPR84 p.Val39Met Uncertain significance Single submitter
Predictors split 7
The independent predictors disagree with each other — read with care.
- GPR84 p.Arg390Trp Likely benign Single submitter
- GPR84 p.Asn104Lys Uncertain significance Single submitter
- GPR84 p.Cys166Arg Uncertain significance Single submitter
- GPR84 p.Leu161Pro Uncertain significance Single submitter
- GPR84 p.Met320Thr Uncertain significance Single submitter
- GPR84 p.Phe9Leu Uncertain significance Single submitter
- GPR84 p.Trp360Ser Uncertain significance Single submitter
All GPR84 variants
Likely benign 2
- p.Arg319Gln Single submitter
- p.Arg390Trp Single submitter ⚠
Uncertain significance 42
- p.Ala208Val Single submitter ⚠
- p.Ala220Thr Single submitter ⚠
- p.Ala304Thr Single submitter ⚠
- p.Arg172Cys Single submitter ⚠
- p.Arg176Trp Single submitter ⚠
- p.Arg203Cys Single submitter ⚠
- p.Arg203His Single submitter ⚠
- p.Arg207Gln Single submitter ⚠
- p.Arg218Gln Single submitter ⚠
- p.Arg237Cys Single submitter ⚠
- p.Arg305Thr Single submitter ⚠
- p.Arg349Trp Single submitter ⚠
- p.Asn104Lys Single submitter ⚠
- p.Asp242His Single submitter ⚠
- p.Asp66Tyr Single submitter ⚠
- p.Cys166Arg Single submitter ⚠
- p.Gly18Asp Single submitter ⚠
- p.Gly190Arg Single submitter ⚠
- p.Gly248Ala Single submitter ⚠
- p.Gly248Glu Single submitter ⚠
- p.Gly315Glu Single submitter ⚠
- p.His124Gln Single submitter ⚠
- p.His85Tyr Single submitter ⚠
- p.Ile254Thr Single submitter ⚠
- p.Leu161Pro Single submitter ⚠
- p.Leu337Pro Single submitter ⚠
- p.Leu58Phe Single submitter ⚠
- p.Leu62Phe Single submitter ⚠
- p.Lys216Gln Single submitter ⚠
- p.Lys316Glu Single submitter ⚠
- p.Met320Thr Single submitter ⚠
- p.Phe9Leu Single submitter ⚠
- p.Pro291Ala Single submitter ⚠
- p.Pro348Ser Single submitter ⚠
- p.Ser192Gly Single submitter ⚠
- p.Ser193Gly Single submitter ⚠
- p.Ser251Ile Single submitter ⚠
- p.Thr63Lys Single submitter ⚠
- p.Trp360Ser Single submitter ⚠
- p.Val164Ile Single submitter ⚠
- p.Val28Gly Single submitter ⚠
- p.Val39Met Single submitter ⚠