GRAMD1A — 111 ClinVar variants
All ClinVar germline GRAMD1A variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 104 flagged for review →
4 Likely benign · 107 Uncertain significance
Full GRAMD1A gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 104
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 84
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- GRAMD1A p.Ala283Val Uncertain significance Single submitter
- GRAMD1A p.Ala315Val Uncertain significance Single submitter
- GRAMD1A p.Ala380Thr Uncertain significance Single submitter
- GRAMD1A p.Ala438Val Uncertain significance Single submitter
- GRAMD1A p.Ala563Asp Uncertain significance Single submitter
- GRAMD1A p.Ala650Ser Uncertain significance Single submitter
- GRAMD1A p.Ala668Val Uncertain significance Single submitter
- GRAMD1A p.Arg10Trp Uncertain significance Single submitter
- GRAMD1A p.Arg116Cys Uncertain significance Single submitter
- GRAMD1A p.Arg139Cys Uncertain significance Single submitter
- GRAMD1A p.Arg186Cys Uncertain significance Single submitter
- GRAMD1A p.Arg20Gln Uncertain significance Single submitter
- GRAMD1A p.Arg273Cys Uncertain significance Single submitter
- GRAMD1A p.Arg30Gln Uncertain significance Single submitter
- GRAMD1A p.Arg30Trp Uncertain significance Single submitter
- GRAMD1A p.Arg382Gln Uncertain significance Single submitter
- GRAMD1A p.Arg382Trp Uncertain significance Single submitter
- GRAMD1A p.Arg420Cys Uncertain significance Single submitter
- GRAMD1A p.Arg449Cys Uncertain significance Single submitter
- GRAMD1A p.Arg498Cys Uncertain significance Single submitter
- GRAMD1A p.Arg562Gln Uncertain significance Single submitter
- GRAMD1A p.Arg578Leu Uncertain significance Single submitter
- GRAMD1A p.Arg578Pro Uncertain significance Single submitter
- GRAMD1A p.Arg578Trp Uncertain significance Single submitter
- GRAMD1A p.Arg590Cys Uncertain significance Single submitter
- GRAMD1A p.Arg66Gln Uncertain significance Single submitter
- GRAMD1A p.Arg686Gln Uncertain significance Single submitter
- GRAMD1A p.Arg70Cys Uncertain significance Single submitter
- GRAMD1A p.Arg718Trp Uncertain significance Single submitter
- GRAMD1A p.Asn279Ser Uncertain significance Single submitter
- GRAMD1A p.Asp109Val Uncertain significance Single submitter
- GRAMD1A p.Asp286Asn Uncertain significance Single submitter
- GRAMD1A p.Asp335Gly Uncertain significance Single submitter
- GRAMD1A p.Asp358Glu Uncertain significance Single submitter
- GRAMD1A p.Asp365Glu Uncertain significance Single submitter
- GRAMD1A p.Gln264Lys Uncertain significance Single submitter
- GRAMD1A p.Gln324Glu Uncertain significance Single submitter
- GRAMD1A p.Gln395Arg Uncertain significance Single submitter
- GRAMD1A p.Gln395His Uncertain significance Single submitter
- GRAMD1A p.Gln61His Uncertain significance Single submitter
- GRAMD1A p.Glu265Val Uncertain significance Single submitter
- GRAMD1A p.Glu381Gly Uncertain significance Single submitter
- GRAMD1A p.Gly218Ser Uncertain significance Single submitter
- GRAMD1A p.Gly238Asp Uncertain significance Single submitter
- GRAMD1A p.Gly454Ser Uncertain significance Single submitter
- GRAMD1A p.Gly542Arg Uncertain significance Single submitter
- GRAMD1A p.Gly551Ser Uncertain significance Single submitter
- GRAMD1A p.Gly9Asp Uncertain significance Single submitter
- GRAMD1A p.Gly9Cys Uncertain significance Single submitter
- GRAMD1A p.His641Arg Uncertain significance Single submitter
- GRAMD1A p.His647Gln Uncertain significance Single submitter
- GRAMD1A p.Leu148Pro Uncertain significance Single submitter
- GRAMD1A p.Leu234Ser Uncertain significance Single submitter
- GRAMD1A p.Leu336Pro Uncertain significance Single submitter
- GRAMD1A p.Pro27Ser Uncertain significance Single submitter
- GRAMD1A p.Pro313Leu Uncertain significance Single submitter
- GRAMD1A p.Pro428Ser Uncertain significance Single submitter
- GRAMD1A p.Pro558Ser Uncertain significance Single submitter
- GRAMD1A p.Pro55Arg Uncertain significance Single submitter
- GRAMD1A p.Pro575His Uncertain significance Single submitter
- GRAMD1A p.Pro600Thr Uncertain significance Single submitter
- GRAMD1A p.Pro6His Uncertain significance Single submitter
- GRAMD1A p.Ser18Leu Uncertain significance Single submitter
- GRAMD1A p.Ser18Pro Uncertain significance Single submitter
- GRAMD1A p.Ser257Leu Uncertain significance Single submitter
- GRAMD1A p.Ser271Leu Uncertain significance Single submitter
- GRAMD1A p.Ser389Leu Uncertain significance Single submitter
- GRAMD1A p.Ser517Asn Uncertain significance Single submitter
- GRAMD1A p.Ser560Asn Uncertain significance Single submitter
- GRAMD1A p.Ser584Leu Uncertain significance Single submitter
- GRAMD1A p.Ser675Gly Uncertain significance Single submitter
- GRAMD1A p.Ser709Leu Uncertain significance Single submitter
- GRAMD1A p.Thr143Met Uncertain significance Single submitter
- GRAMD1A p.Thr323Ile Uncertain significance Single submitter
- GRAMD1A p.Thr330Ala Uncertain significance Single submitter
- GRAMD1A p.Thr407Met Uncertain significance Single submitter
- GRAMD1A p.Thr445Met Uncertain significance Single submitter
- GRAMD1A p.Thr464Met Uncertain significance Single submitter
- GRAMD1A p.Thr642Ala Uncertain significance Single submitter
- GRAMD1A p.Trp516Gly Uncertain significance Single submitter
- GRAMD1A p.Val41Met Uncertain significance Single submitter
- GRAMD1A p.Val627Ile Uncertain significance Single submitter
- GRAMD1A p.Val676Met Uncertain significance Single submitter
- GRAMD1A p.Val689Met Uncertain significance Single submitter
Predictors split 20
The independent predictors disagree with each other — read with care.
- GRAMD1A p.Arg207Cys Uncertain significance Single submitter
- GRAMD1A p.Arg20Trp Uncertain significance Single submitter
- GRAMD1A p.Arg486Trp Uncertain significance Single submitter
- GRAMD1A p.Arg500Gln Uncertain significance Single submitter
- GRAMD1A p.Arg554Trp Uncertain significance Single submitter
- GRAMD1A p.Arg632His Uncertain significance Single submitter
- GRAMD1A p.Asn348Ile Uncertain significance Single submitter
- GRAMD1A p.Glu637Asp Uncertain significance Single submitter
- GRAMD1A p.Gly518Ser Uncertain significance Single submitter
- GRAMD1A p.Ile163Met Uncertain significance Single submitter
- GRAMD1A p.Met695Val Uncertain significance Single submitter
- GRAMD1A p.Phe630Ile Uncertain significance Single submitter
- GRAMD1A p.Pro657Leu Uncertain significance Single submitter
- GRAMD1A p.Ser225Gly Uncertain significance Single submitter
- GRAMD1A p.Ser307Tyr Uncertain significance Single submitter
- GRAMD1A p.Ser509Leu Uncertain significance Single submitter
- GRAMD1A p.Ser645Phe Uncertain significance Single submitter
- GRAMD1A p.Thr424Met Uncertain significance Single submitter
- GRAMD1A p.Thr659Met Uncertain significance Single submitter
- GRAMD1A p.Tyr425Cys Uncertain significance Single submitter
All GRAMD1A variants
Likely benign 4
- p.Arg262His Single submitter
- p.Arg718Gln Single submitter
- p.Ile621Val Single submitter
- p.Thr241Ser Single submitter
Uncertain significance 107
- p.Ala283Val Single submitter ⚠
- p.Ala315Val Single submitter ⚠
- p.Ala380Thr Single submitter ⚠
- p.Ala438Val Single submitter ⚠
- p.Ala563Asp Single submitter ⚠
- p.Ala650Ser Single submitter ⚠
- p.Ala668Val Single submitter ⚠
- p.Arg10Trp Single submitter ⚠
- p.Arg116Cys Single submitter ⚠
- p.Arg139Cys Single submitter ⚠
- p.Arg186Cys Single submitter ⚠
- p.Arg207Cys Single submitter ⚠
- p.Arg20Gln Single submitter ⚠
- p.Arg20Trp Single submitter ⚠
- p.Arg273Cys Single submitter ⚠
- p.Arg30Gln Single submitter ⚠
- p.Arg30Trp Single submitter ⚠
- p.Arg382Gln Single submitter ⚠
- p.Arg382Trp Single submitter ⚠
- p.Arg420Cys Single submitter ⚠
- p.Arg449Cys Single submitter ⚠
- p.Arg486Trp Single submitter ⚠
- p.Arg490Trp Single submitter
- p.Arg498Cys Single submitter ⚠
- p.Arg500Gln Single submitter ⚠
- p.Arg554Trp Single submitter ⚠
- p.Arg562Gln Single submitter ⚠
- p.Arg578Leu Single submitter ⚠
- p.Arg578Pro Single submitter ⚠
- p.Arg578Trp Single submitter ⚠
- p.Arg590Cys Single submitter ⚠
- p.Arg632His Single submitter ⚠
- p.Arg66Gln Single submitter ⚠
- p.Arg686Gln Single submitter ⚠
- p.Arg70Cys Single submitter ⚠
- p.Arg718Trp Single submitter ⚠
- p.Asn279Ser Single submitter ⚠
- p.Asn348Ile Single submitter ⚠
- p.Asp109Val Single submitter ⚠
- p.Asp286Asn Single submitter ⚠
- p.Asp335Gly Single submitter ⚠
- p.Asp358Glu Single submitter ⚠
- p.Asp365Glu Single submitter ⚠
- p.Gln264Lys Single submitter ⚠
- p.Gln324Glu Single submitter ⚠
- p.Gln35fs Single submitter
- p.Gln395Arg Single submitter ⚠
- p.Gln395His Single submitter ⚠
- p.Gln61His Single submitter ⚠
- p.Glu265Val Single submitter ⚠
- p.Glu381Gly Single submitter ⚠
- p.Glu637Asp Single submitter ⚠
- p.Gly218Ser Single submitter ⚠
- p.Gly238Asp Single submitter ⚠
- p.Gly454Ser Single submitter ⚠
- p.Gly518Ser Single submitter ⚠
- p.Gly542Arg Single submitter ⚠
- p.Gly551Ser Single submitter ⚠
- p.Gly9Asp Single submitter ⚠
- p.Gly9Cys Single submitter ⚠
- p.His641Arg Single submitter ⚠
- p.His647Gln Single submitter ⚠
- p.Ile163Met Single submitter ⚠
- p.Leu148Pro Single submitter ⚠
- p.Leu234Ser Single submitter ⚠
- p.Leu336Pro Single submitter ⚠
- p.Met695Val Single submitter ⚠
- p.Phe630Ile Single submitter ⚠
- p.Pro27Ser Single submitter ⚠
- p.Pro313Leu Single submitter ⚠
- p.Pro428Ser Single submitter ⚠
- p.Pro558Ser Single submitter ⚠
- p.Pro55Arg Single submitter ⚠
- p.Pro575His Single submitter ⚠
- p.Pro600Thr Single submitter ⚠
- p.Pro657Leu Single submitter ⚠
- p.Pro6His Single submitter ⚠
- p.Ser18Leu Single submitter ⚠
- p.Ser18Pro Single submitter ⚠
- p.Ser225Gly Single submitter ⚠
- p.Ser257Leu Single submitter ⚠
- p.Ser271Leu Single submitter ⚠
- p.Ser307Tyr Single submitter ⚠
- p.Ser389Leu Single submitter ⚠
- p.Ser509Leu Single submitter ⚠
- p.Ser517Asn Single submitter ⚠
- p.Ser560Asn Single submitter ⚠
- p.Ser584Leu Single submitter ⚠
- p.Ser645Phe Single submitter ⚠
- p.Ser675Gly Single submitter ⚠
- p.Ser709Leu Single submitter ⚠
- p.Thr143Met Single submitter ⚠
- p.Thr159Met Single submitter
- p.Thr323Ile Single submitter ⚠
- p.Thr330Ala Single submitter ⚠
- p.Thr407Met Single submitter ⚠
- p.Thr424Met Single submitter ⚠
- p.Thr445Met Single submitter ⚠
- p.Thr464Met Single submitter ⚠
- p.Thr642Ala Single submitter ⚠
- p.Thr659Met Single submitter ⚠
- p.Trp516Gly Single submitter ⚠
- p.Tyr425Cys Single submitter ⚠
- p.Val41Met Single submitter ⚠
- p.Val627Ile Single submitter ⚠
- p.Val676Met Single submitter ⚠
- p.Val689Met Single submitter ⚠