GRB2 — 8 ClinVar variants
All ClinVar germline GRB2 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 4 flagged for review →
1 Benign · 7 Uncertain significance
Full GRB2 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 4
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 4
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
All GRB2 variants
Benign 1
- p.His79= Multiple submitters
Uncertain significance 7
- p.Ala82Ser Single submitter ⚠
- p.Arg207Cys Single submitter
- p.Arg215Trp Single submitter ⚠
- p.Asn126Ser Single submitter ⚠
- p.Asp133Asn Single submitter ⚠
- p.Asp23Asn Single submitter
- p.Glu87Asp Single submitter