GRB7 — 81 ClinVar variants
All ClinVar germline GRB7 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 61 flagged for review →
6 Benign · 6 Likely benign · 69 Uncertain significance
Full GRB7 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 61
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 50
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- GRB7 p.Ala137Thr Uncertain significance Single submitter
- GRB7 p.Ala416Pro Uncertain significance Single submitter
- GRB7 p.Ala90Val Uncertain significance Single submitter
- GRB7 p.Arg100His Uncertain significance Single submitter
- GRB7 p.Arg182Gln Uncertain significance Single submitter
- GRB7 p.Arg243Gln Uncertain significance Single submitter
- GRB7 p.Arg427His Uncertain significance Single submitter
- GRB7 p.Arg443Gln Uncertain significance Single submitter
- GRB7 p.Arg462Gln Uncertain significance Single submitter
- GRB7 p.Arg516His Uncertain significance Single submitter
- GRB7 p.Arg529Gln Uncertain significance Single submitter
- GRB7 p.Arg55Gln Uncertain significance Single submitter
- GRB7 p.Asp209Asn Uncertain significance Single submitter
- GRB7 p.Asp268Glu Uncertain significance Single submitter
- GRB7 p.Asp97Gly Uncertain significance Single submitter
- GRB7 p.Cys207Tyr Uncertain significance Single submitter
- GRB7 p.Cys358Ser Uncertain significance Single submitter
- GRB7 p.Gln350Arg Uncertain significance Single submitter
- GRB7 p.Glu141Lys Uncertain significance Single submitter
- GRB7 p.Glu201Gln Uncertain significance Single submitter
- GRB7 p.Glu37Lys Uncertain significance Single submitter
- GRB7 p.Gly121Asp Uncertain significance Single submitter
- GRB7 p.Gly418Ser Uncertain significance Single submitter
- GRB7 p.Gly92Arg Uncertain significance Single submitter
- GRB7 p.Gly92Glu Uncertain significance Single submitter
- GRB7 p.His408Asn Uncertain significance Single submitter
- GRB7 p.Leu138Ser Uncertain significance Single submitter
- GRB7 p.Leu154Arg Uncertain significance Single submitter
- GRB7 p.Leu198Val Uncertain significance Single submitter
- GRB7 p.Leu253Trp Uncertain significance Single submitter
- GRB7 p.Lys183Asn Uncertain significance Single submitter
- GRB7 p.Phe229Val Uncertain significance Single submitter
- GRB7 p.Phe377Leu Uncertain significance Single submitter
- GRB7 p.Pro21Thr Uncertain significance Single submitter
- GRB7 p.Pro363Ala Uncertain significance Single submitter
- GRB7 p.Pro363Leu Uncertain significance Single submitter
- GRB7 p.Pro520Leu Uncertain significance Single submitter
- GRB7 p.Ser108Gly Uncertain significance Single submitter
- GRB7 p.Ser197Phe Uncertain significance Single submitter
- GRB7 p.Ser361Phe Uncertain significance Single submitter
- GRB7 p.Thr23Ala Uncertain significance Single submitter
- GRB7 p.Thr265Asn Uncertain significance Single submitter
- GRB7 p.Thr528Met Uncertain significance Single submitter
- GRB7 p.Trp431Cys Uncertain significance Single submitter
- GRB7 p.Val106Met Uncertain significance Single submitter
- GRB7 p.Val173Leu Uncertain significance Single submitter
- GRB7 p.Val275Met Uncertain significance Single submitter
- GRB7 p.Val285Met Uncertain significance Single submitter
- GRB7 p.Val509Met Uncertain significance Single submitter
- GRB7 p.Val530Met Uncertain significance Single submitter
Predictors split 11
The independent predictors disagree with each other — read with care.
- GRB7 p.Arg125Cys Uncertain significance Single submitter
- GRB7 p.Arg239Trp Uncertain significance Single submitter
- GRB7 p.Arg326Cys Uncertain significance Single submitter
- GRB7 p.Arg326His Uncertain significance Single submitter
- GRB7 p.Arg435Cys Uncertain significance Single submitter
- GRB7 p.Gly175Arg Uncertain significance Single submitter
- GRB7 p.Gly300Ser Uncertain significance Single submitter
- GRB7 p.Ser228Arg Uncertain significance Single submitter
- GRB7 p.Ser422Ile Uncertain significance Single submitter
- GRB7 p.Thr23Asn Uncertain significance Single submitter
- GRB7 p.Val477Met Uncertain significance Single submitter
All GRB7 variants
Benign 6
- c.1210-4A>G Multiple submitters
- c.307-4G>A Multiple submitters
- p.Pro362Leu Multiple submitters
- p.Thr419Lys Multiple submitters
- p.His161= Single submitter
- p.Thr287Met Single submitter
Likely benign 6
- c.307-5C>T Single submitter
- c.-27G>A Single submitter
- p.Arg100Cys Single submitter
- p.His512= Single submitter
- p.Pro388= Single submitter
- p.Thr33Ala Single submitter
Uncertain significance 69
- c.-17T>C Single submitter
- c.-2C>A Single submitter
- c.-45G>A Single submitter
- c.-50G>A Single submitter
- c.-6G>A Single submitter
- p.Ala137Thr Single submitter ⚠
- p.Ala416Pro Single submitter ⚠
- p.Ala90Val Single submitter ⚠
- p.Arg100His Single submitter ⚠
- p.Arg125Cys Single submitter ⚠
- p.Arg182Gln Single submitter ⚠
- p.Arg239Trp Single submitter ⚠
- p.Arg243Gln Single submitter ⚠
- p.Arg326Cys Single submitter ⚠
- p.Arg326His Single submitter ⚠
- p.Arg427His Single submitter ⚠
- p.Arg435Cys Single submitter ⚠
- p.Arg443Gln Single submitter ⚠
- p.Arg462Gln Single submitter ⚠
- p.Arg516His Single submitter ⚠
- p.Arg529Gln Single submitter ⚠
- p.Arg55Gln Single submitter ⚠
- p.Asp209Asn Single submitter ⚠
- p.Asp268Glu Single submitter ⚠
- p.Asp97Gly Single submitter ⚠
- p.Cys207Tyr Single submitter ⚠
- p.Cys358Ser Single submitter ⚠
- p.Gln350Arg Single submitter ⚠
- p.Glu141Lys Single submitter ⚠
- p.Glu201Gln Single submitter ⚠
- p.Glu280Lys Single submitter
- p.Glu37Lys Single submitter ⚠
- p.Gly121Asp Single submitter ⚠
- p.Gly175Arg Single submitter ⚠
- p.Gly300Ser Single submitter ⚠
- p.Gly418Ser Single submitter ⚠
- p.Gly92Arg Single submitter ⚠
- p.Gly92Glu Single submitter ⚠
- p.His408Asn Single submitter ⚠
- p.Leu138Ser Single submitter ⚠
- p.Leu154Arg Single submitter ⚠
- p.Leu198Val Single submitter ⚠
- p.Leu253Trp Single submitter ⚠
- p.Lys183Asn Single submitter ⚠
- p.Met1Arg Single submitter
- p.Phe229Val Single submitter ⚠
- p.Phe377Leu Single submitter ⚠
- p.Pro21Thr Single submitter ⚠
- p.Pro363Ala Single submitter ⚠
- p.Pro363Leu Single submitter ⚠
- p.Pro520Leu Single submitter ⚠
- p.Ser108Gly Single submitter ⚠
- p.Ser197Phe Single submitter ⚠
- p.Ser228Arg Single submitter ⚠
- p.Ser361Phe Single submitter ⚠
- p.Ser422Ile Single submitter ⚠
- p.Thr23Ala Single submitter ⚠
- p.Thr23Asn Single submitter ⚠
- p.Thr265Asn Single submitter ⚠
- p.Thr528Met Single submitter ⚠
- p.Trp431Cys Single submitter ⚠
- p.Val106Met Single submitter ⚠
- p.Val164Met Single submitter
- p.Val173Leu Single submitter ⚠
- p.Val275Met Single submitter ⚠
- p.Val285Met Single submitter ⚠
- p.Val477Met Single submitter ⚠
- p.Val509Met Single submitter ⚠
- p.Val530Met Single submitter ⚠