Sugi Variant

Sugi Variant/GREM1

GREM1 — 422 ClinVar variants

All ClinVar germline GREM1 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 214 flagged for review →

3 Conflicting · 59 Benign · 143 Likely benign · 217 Uncertain significance

Full GREM1 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions

⚑ Evidence disagreements 214

Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.

Predictors agree, ClinVar conflicts 1

ClinVar submitters conflict, but the independent predictors unanimously agree — a QC review flag, not a reclassification.

Predictors lean, ClinVar uncertain 159

ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification. · showing the 150 best-reviewed of 159

Predictors split 54

The independent predictors disagree with each other — read with care.

All GREM1 variants

Conflicting classifications of pathogenicity 3

  • p.Arg91= Single submitter hereditary neoplastic syndrome
  • p.Gln139= Single submitter hereditary neoplastic syndrome
  • p.Pro35Ala Single submitter hereditary neoplastic syndrome ⚠

Benign 59

Likely benign 143

  • p.Ala80= Multiple submitters hereditary neoplastic syndrome
  • p.Gln40= Multiple submitters hereditary neoplastic syndrome
  • p.Glu85= Multiple submitters hereditary neoplastic syndrome
  • p.Lys174= Multiple submitters hereditary neoplastic syndrome
  • p.Pro35= Multiple submitters hereditary neoplastic syndrome
  • p.Tyr119= Multiple submitters hereditary neoplastic syndrome
  • c.-1-23C>G Single submitter
  • c.-122A>T Single submitter
  • c.-180G>A Single submitter
  • c.-192G>T Single submitter
  • c.-196C>G Single submitter
  • c.-2+37C>T Single submitter
  • c.-2+9G>C Single submitter
  • c.-209C>T Single submitter
  • c.-23C>G Single submitter
  • c.-41C>T Single submitter
  • c.-49G>A Single submitter
  • c.-64C>G Single submitter
  • c.-72G>A Single submitter
  • c.-76C>G Single submitter
  • c.-85G>A Single submitter
  • p.Ala10= Single submitter hereditary neoplastic syndrome
  • p.Ala21= Single submitter hereditary neoplastic syndrome
  • p.Ala22= Single submitter hereditary neoplastic syndrome
  • p.Ala32= Single submitter hereditary neoplastic syndrome
  • p.Ala39= Single submitter hereditary neoplastic syndrome
  • p.Ala5= Single submitter hereditary neoplastic syndrome
  • p.Ala67= Single submitter hereditary neoplastic syndrome
  • p.Arg111= Single submitter hereditary neoplastic syndrome
  • p.Arg129= Single submitter hereditary neoplastic syndrome
  • p.Arg132= Single submitter hereditary neoplastic syndrome
  • p.Arg172= Single submitter hereditary neoplastic syndrome
  • p.Arg177= Single submitter hereditary neoplastic syndrome
  • p.Arg56= Single submitter hereditary neoplastic syndrome
  • p.Arg58= Single submitter hereditary neoplastic syndrome
  • p.Arg64= Single submitter hereditary neoplastic syndrome
  • p.Asn109= Single submitter hereditary neoplastic syndrome
  • p.Asn115= Single submitter hereditary neoplastic syndrome
  • p.Asn123= Single submitter hereditary neoplastic syndrome
  • p.Asn42= Single submitter hereditary neoplastic syndrome
  • p.Asn57= Single submitter hereditary neoplastic syndrome
  • p.Asp92= Single submitter hereditary neoplastic syndrome
  • p.Cys108= Single submitter hereditary neoplastic syndrome
  • p.Cys118= Single submitter hereditary neoplastic syndrome
  • p.Cys158= Single submitter hereditary neoplastic syndrome
  • p.Cys176= Single submitter hereditary neoplastic syndrome
  • p.Cys178= Single submitter hereditary neoplastic syndrome
  • p.Gln121= Single submitter hereditary neoplastic syndrome
  • p.Gln175= Single submitter hereditary neoplastic syndrome
  • p.Gln30= Single submitter hereditary neoplastic syndrome
  • p.Gln48= Single submitter hereditary neoplastic syndrome
  • p.Gln62= Single submitter hereditary neoplastic syndrome
  • p.Gln78= Single submitter hereditary neoplastic syndrome
  • p.Glu105= Single submitter hereditary neoplastic syndrome
  • p.Glu106= Single submitter hereditary neoplastic syndrome
  • p.Glu134= Single submitter hereditary neoplastic syndrome
  • p.Glu23= Single submitter hereditary neoplastic syndrome
  • p.Glu79= Single submitter hereditary neoplastic syndrome
  • p.Gly136= Single submitter hereditary neoplastic syndrome
  • p.Gly16= Single submitter hereditary neoplastic syndrome
  • p.Gly31= Single submitter hereditary neoplastic syndrome
  • p.Gly59= Single submitter hereditary neoplastic syndrome
  • p.Gly63= Single submitter hereditary neoplastic syndrome
  • p.Gly65= Single submitter hereditary neoplastic syndrome
  • p.Gly70= Single submitter hereditary neoplastic syndrome
  • p.Gly9= Single submitter hereditary neoplastic syndrome
  • p.His104= Single submitter hereditary neoplastic syndrome
  • p.His130= Single submitter hereditary neoplastic syndrome
  • p.His82= Single submitter hereditary neoplastic syndrome
  • p.Ile103= Single submitter hereditary neoplastic syndrome
  • p.Ile113= Single submitter hereditary neoplastic syndrome
  • p.Ile127= Single submitter hereditary neoplastic syndrome
  • p.Ile131= Single submitter hereditary neoplastic syndrome
  • p.Ile181= Single submitter hereditary neoplastic syndrome
  • p.Ile33= Single submitter hereditary neoplastic syndrome
  • p.Leu11= Single submitter hereditary neoplastic syndrome
  • p.Leu12= Single submitter hereditary neoplastic syndrome
  • p.Leu13= Single submitter hereditary neoplastic syndrome
  • p.Leu14= Single submitter hereditary neoplastic syndrome
  • p.Leu15= Single submitter hereditary neoplastic syndrome
  • p.Leu156= Single submitter hereditary neoplastic syndrome
  • p.Leu161= Single submitter hereditary neoplastic syndrome
  • p.Leu18= Single submitter hereditary neoplastic syndrome
  • p.Leu19= Single submitter hereditary neoplastic syndrome
  • p.Leu74= Single submitter hereditary neoplastic syndrome
  • p.Leu81= Single submitter hereditary neoplastic syndrome
  • p.Leu89= Single submitter hereditary neoplastic syndrome
  • p.Leu99= Single submitter hereditary neoplastic syndrome
  • p.Lys133Arg Single submitter hereditary neoplastic syndrome
  • p.Lys145= Single submitter hereditary neoplastic syndrome
  • p.Lys166= Single submitter hereditary neoplastic syndrome
  • p.Lys167= Single submitter hereditary neoplastic syndrome
  • p.Lys25= Single submitter hereditary neoplastic syndrome
  • p.Lys27= Single submitter hereditary neoplastic syndrome
  • p.Lys38= Single submitter hereditary neoplastic syndrome
  • p.Lys87= Single submitter hereditary neoplastic syndrome
  • p.Lys90= Single submitter hereditary neoplastic syndrome
  • p.Met153Ile Single submitter hereditary neoplastic syndrome
  • p.Phe117= Single submitter hereditary neoplastic syndrome
  • p.Phe143= Single submitter hereditary neoplastic syndrome
  • p.Phe149= Single submitter hereditary neoplastic syndrome
  • p.Pro128= Single submitter hereditary neoplastic syndrome
  • p.Pro146= Single submitter hereditary neoplastic syndrome
  • p.Pro164= Single submitter hereditary neoplastic syndrome
  • p.Pro20= Single submitter hereditary neoplastic syndrome
  • p.Pro34= Single submitter hereditary neoplastic syndrome
  • p.Pro50= Single submitter hereditary neoplastic syndrome
  • p.Pro53= Single submitter hereditary neoplastic syndrome
  • p.Pro69= Single submitter hereditary neoplastic syndrome
  • p.Pro98= Single submitter hereditary neoplastic syndrome
  • p.Ser110= Single submitter hereditary neoplastic syndrome
  • p.Ser124= Single submitter hereditary neoplastic syndrome
  • p.Ser137= Single submitter hereditary neoplastic syndrome
  • p.Ser142= Single submitter hereditary neoplastic syndrome
  • p.Ser180= Single submitter hereditary neoplastic syndrome
  • p.Ser2= Single submitter hereditary neoplastic syndrome
  • p.Ser29= Single submitter hereditary neoplastic syndrome
  • p.Ser44= Single submitter hereditary neoplastic syndrome
  • p.Ser49= Single submitter hereditary neoplastic syndrome
  • p.Ser55= Single submitter hereditary neoplastic syndrome
  • p.Ser76= Single submitter hereditary neoplastic syndrome
  • p.Ter185= Single submitter hereditary neoplastic syndrome
  • p.Thr102= Single submitter hereditary neoplastic syndrome
  • p.Thr112= Single submitter hereditary neoplastic syndrome
  • p.Thr150= Single submitter hereditary neoplastic syndrome
  • p.Thr151= Single submitter hereditary neoplastic syndrome
  • p.Thr165= Single submitter hereditary neoplastic syndrome
  • p.Thr17= Single submitter hereditary neoplastic syndrome
  • p.Thr171= Single submitter hereditary neoplastic syndrome
  • p.Thr47= Single submitter hereditary neoplastic syndrome
  • p.Thr47Ser Single submitter hereditary neoplastic syndrome
  • p.Thr66= Single submitter hereditary neoplastic syndrome
  • p.Thr7= Single submitter hereditary neoplastic syndrome
  • p.Thr84= Single submitter hereditary neoplastic syndrome
  • p.Tyr6= Single submitter hereditary neoplastic syndrome
  • p.Tyr88= Single submitter hereditary neoplastic syndrome
  • p.Val170= Single submitter hereditary neoplastic syndrome
  • p.Val173= Single submitter hereditary neoplastic syndrome
  • p.Val73= Single submitter hereditary neoplastic syndrome
  • c.-1-797A>G No assertion criteria hereditary neoplastic syndrome
  • c.-2+1514T>G No assertion criteria hereditary neoplastic syndrome
  • c.-2+2056C>T No assertion criteria hereditary neoplastic syndrome
  • c.*9C>G No assertion criteria GREM1-related disorder

Uncertain significance 217