GRID1 — 150 ClinVar variants
All ClinVar germline GRID1 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 131 flagged for review →
1 Pathogenic · 4 Benign · 2 Likely benign · 143 Uncertain significance
Full GRID1 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 131
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 106
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
-
GRID1 p.Ala127Thr
Uncertain significance
Multiple submitters
GRID1-associated neurodevelopmental disorder
-
GRID1 p.Ala603Asp
Uncertain significance
Multiple submitters
GRID1-associated neurodevelopmental disorder
-
GRID1 p.Arg384Gln
Uncertain significance
Multiple submitters
GRID1-associated neurodevelopmental disorder
- GRID1 p.Arg879His Uncertain significance Multiple submitters
-
GRID1 p.Asp307Asn
Uncertain significance
Multiple submitters
GRID1-associated neurodevelopmental disorder
-
GRID1 p.Gly716Arg
Uncertain significance
Multiple submitters
GRID1-associated neurodevelopmental disorder
-
GRID1 p.Pro120Gln
Uncertain significance
Multiple submitters
GRID1-associated neurodevelopmental disorder
-
GRID1 p.Thr604Ile
Uncertain significance
Multiple submitters
GRID1-associated neurodevelopmental disorder
-
GRID1 p.Val450Met
Uncertain significance
Multiple submitters
GRID1-associated neurodevelopmental disorder
- GRID1 p.Ala564Thr Uncertain significance Single submitter
- GRID1 p.Ala571Thr Uncertain significance Single submitter
- GRID1 p.Ala601Ser Uncertain significance Single submitter
- GRID1 p.Ala603Val Uncertain significance Single submitter
- GRID1 p.Ala686Thr Uncertain significance Single submitter
- GRID1 p.Ala718Ser Uncertain significance Single submitter
-
GRID1 p.Ala817Thr
Uncertain significance
Single submitter
GRID1-associated neurodevelopmental disorder
- GRID1 p.Ala889Thr Uncertain significance Single submitter
- GRID1 p.Ala889Val Uncertain significance Single submitter
- GRID1 p.Arg118Leu Uncertain significance Single submitter
- GRID1 p.Arg148His Uncertain significance Single submitter
- GRID1 p.Arg161His Uncertain significance Single submitter
- GRID1 p.Arg187Gln Uncertain significance Single submitter
- GRID1 p.Arg187Trp Uncertain significance Single submitter
- GRID1 p.Arg225Cys Uncertain significance Single submitter
- GRID1 p.Arg226Cys Uncertain significance Single submitter
- GRID1 p.Arg353Gln Uncertain significance Single submitter
- GRID1 p.Arg363Lys Uncertain significance Single submitter
- GRID1 p.Arg428Lys Uncertain significance Single submitter
- GRID1 p.Arg433His Uncertain significance Single submitter
- GRID1 p.Arg433Ser Uncertain significance Single submitter
- GRID1 p.Arg491Thr Uncertain significance Single submitter
- GRID1 p.Arg585Lys Uncertain significance Single submitter
- GRID1 p.Arg631Cys Uncertain significance Single submitter
- GRID1 p.Arg631Ser Uncertain significance Single submitter
- GRID1 p.Arg692Gln Uncertain significance Single submitter
- GRID1 p.Arg710Gln Uncertain significance Single submitter
- GRID1 p.Arg918Gln Uncertain significance Single submitter
- GRID1 p.Arg941Gln Uncertain significance Single submitter
- GRID1 p.Arg977Gln Uncertain significance Single submitter
- GRID1 p.Asn150Ser Uncertain significance Single submitter
- GRID1 p.Asn241Ser Uncertain significance Single submitter
- GRID1 p.Asn715Asp Uncertain significance Single submitter
- GRID1 p.Asp489His Uncertain significance Single submitter
- GRID1 p.Asp798Glu Uncertain significance Single submitter
- GRID1 p.Gln117Glu Uncertain significance Single submitter
- GRID1 p.Glu549Gly Uncertain significance Single submitter
- GRID1 p.Glu549Lys Uncertain significance Single submitter
- GRID1 p.Gly121Arg Uncertain significance Single submitter
-
GRID1 p.Gly136Asp
Uncertain significance
Single submitter
GRID1-associated neurodevelopmental disorder
- GRID1 p.Gly493Ser Uncertain significance Single submitter
- GRID1 p.Gly506Arg Uncertain significance Single submitter
- GRID1 p.Gly614Val Uncertain significance Single submitter
- GRID1 p.Gly771Val Uncertain significance Single submitter
- GRID1 p.Gly906Arg Uncertain significance Single submitter
- GRID1 p.Gly907Ser Uncertain significance Single submitter
- GRID1 p.Gly995Asp Uncertain significance Single submitter
-
GRID1 p.His373Gln
Uncertain significance
Single submitter
GRID1-associated neurodevelopmental disorder
- GRID1 p.Ile175Val Uncertain significance Single submitter
-
GRID1 p.Ile456Leu
Uncertain significance
Single submitter
GRID1-associated neurodevelopmental disorder
- GRID1 p.Ile505Val Uncertain significance Single submitter
- GRID1 p.Ile554Phe Uncertain significance Single submitter
- GRID1 p.Ile632Leu Uncertain significance Single submitter
- GRID1 p.Ile64Val Uncertain significance Single submitter
- GRID1 p.Leu190Ile Uncertain significance Single submitter
- GRID1 p.Leu425Phe Uncertain significance Single submitter
- GRID1 p.Leu844Val Uncertain significance Single submitter
-
GRID1 p.Lys199Arg
Uncertain significance
Single submitter
GRID1-associated neurodevelopmental disorder
- GRID1 p.Lys866Arg Uncertain significance Single submitter
-
GRID1 p.Met167Val
Uncertain significance
Single submitter
GRID1-associated neurodevelopmental disorder
- GRID1 p.Met504Arg Uncertain significance Single submitter
- GRID1 p.Phe581Leu Uncertain significance Single submitter
- GRID1 p.Pro390Ser Uncertain significance Single submitter
- GRID1 p.Pro429Arg Uncertain significance Single submitter
-
GRID1 p.Pro429Thr
Uncertain significance
Single submitter
GRID1-associated neurodevelopmental disorder
- GRID1 p.Pro488Ser Uncertain significance Single submitter
- GRID1 p.Pro548Ser Uncertain significance Single submitter
- GRID1 p.Pro664Leu Uncertain significance Single submitter
-
GRID1 p.Pro952Leu
Uncertain significance
Single submitter
GRID1-associated neurodevelopmental disorder
-
GRID1 p.Pro984Ser
Uncertain significance
Single submitter
GRID1-associated neurodevelopmental disorder
- GRID1 p.Pro993Arg Uncertain significance Single submitter
- GRID1 p.Ser287Tyr Uncertain significance Single submitter
- GRID1 p.Ser607Gly Uncertain significance Single submitter
- GRID1 p.Ser703Asn Uncertain significance Single submitter
- GRID1 p.Ser757Leu Uncertain significance Single submitter
- GRID1 p.Ser818Gly Uncertain significance Single submitter
-
GRID1 p.Ser897Leu
Uncertain significance
Single submitter
GRID1-associated neurodevelopmental disorder
- GRID1 p.Thr206Ile Uncertain significance Single submitter
- GRID1 p.Thr279Ile Uncertain significance Single submitter
- GRID1 p.Thr295Ala Uncertain significance Single submitter
- GRID1 p.Thr295Ser Uncertain significance Single submitter
- GRID1 p.Thr499Ala Uncertain significance Single submitter
- GRID1 p.Thr499Asn Uncertain significance Single submitter
- GRID1 p.Thr641Met Uncertain significance Single submitter
-
GRID1 p.Thr752Met
Uncertain significance
Single submitter
GRID1-associated neurodevelopmental disorder
- GRID1 p.Thr794Ala Uncertain significance Single submitter
- GRID1 p.Thr864Ala Uncertain significance Single submitter
- GRID1 p.Thr864Ile Uncertain significance Single submitter
- GRID1 p.Trp637Cys Uncertain significance Single submitter
-
GRID1 p.Val166Ile
Uncertain significance
Single submitter
GRID1-associated neurodevelopmental disorder
- GRID1 p.Val192Ile Uncertain significance Single submitter
- GRID1 p.Val380Ala Uncertain significance Single submitter
- GRID1 p.Val470Ala Uncertain significance Single submitter
- GRID1 p.Val589Met Uncertain significance Single submitter
- GRID1 p.Val617Ile Uncertain significance Single submitter
- GRID1 p.Val625Met Uncertain significance Single submitter
-
GRID1 p.Thr295Met
Uncertain significance
No assertion criteria
prostate cancer
Predictors split 25
The independent predictors disagree with each other — read with care.
-
GRID1 p.Arg221Gln
Uncertain significance
Multiple submitters
GRID1-associated neurodevelopmental disorder
-
GRID1 p.Ala236Ser
Uncertain significance
Single submitter
GRID1-associated neurodevelopmental disorder
- GRID1 p.Ala347Gly Uncertain significance Single submitter
-
GRID1 p.Arg161Cys
Uncertain significance
Single submitter
GRID1-associated neurodevelopmental disorder
- GRID1 p.Arg176His Uncertain significance Single submitter
- GRID1 p.Arg226His Uncertain significance Single submitter
- GRID1 p.Arg296Trp Uncertain significance Single submitter
-
GRID1 p.Arg300Leu
Uncertain significance
Single submitter
GRID1-associated neurodevelopmental disorder
-
GRID1 p.Arg341Gln
Uncertain significance
Single submitter
GRID1-associated neurodevelopmental disorder
- GRID1 p.Arg585Ser Uncertain significance Single submitter
- GRID1 p.Arg859Trp Uncertain significance Single submitter
- GRID1 p.Asp290His Uncertain significance Single submitter
-
GRID1 p.Asp684His
Uncertain significance
Single submitter
GRID1-associated neurodevelopmental disorder
- GRID1 p.Cys568Ser Uncertain significance Single submitter
- GRID1 p.Gln978His Uncertain significance Single submitter
- GRID1 p.Glu172Lys Uncertain significance Single submitter
-
GRID1 p.Glu447Lys
Uncertain significance
Single submitter
GRID1-associated neurodevelopmental disorder
- GRID1 p.His299Asp Uncertain significance Single submitter
- GRID1 p.His776Gln Uncertain significance Single submitter
- GRID1 p.Lys547Glu Uncertain significance Single submitter
- GRID1 p.Met109Thr Uncertain significance Single submitter
-
GRID1 p.Pro286Leu
Uncertain significance
Single submitter
GRID1-associated neurodevelopmental disorder
- GRID1 p.Val565Met Uncertain significance Single submitter
-
GRID1 p.Arg148Cys
Benign
No assertion criteria
Abnormality of neuronal migration
-
GRID1 p.Pro146Leu
Benign
No assertion criteria
Abnormality of neuronal migration
All GRID1 variants
Pathogenic 1
- p.Ala650Thr Single submitter GRID1-associated neurodevelopmental disorder
Benign 4
- p.Met430Val Multiple submitters
- p.Val529Ile Multiple submitters
- p.Arg148Cys No assertion criteria Abnormality of neuronal migration ⚠
- p.Pro146Leu No assertion criteria Abnormality of neuronal migration ⚠
Likely benign 2
- p.Met964Ile Single submitter
- p.Ile26= No assertion criteria GRID1-related disorder
Uncertain significance 143
- p.Ala127Thr Multiple submitters GRID1-associated neurodevelopmental disorder ⚠
- p.Ala603Asp Multiple submitters GRID1-associated neurodevelopmental disorder ⚠
- p.Arg221Gln Multiple submitters GRID1-associated neurodevelopmental disorder ⚠
- p.Arg384Gln Multiple submitters GRID1-associated neurodevelopmental disorder ⚠
- p.Arg879His Multiple submitters ⚠
- p.Asp307Asn Multiple submitters GRID1-associated neurodevelopmental disorder ⚠
- p.Gly716Arg Multiple submitters GRID1-associated neurodevelopmental disorder ⚠
- p.Pro120Gln Multiple submitters GRID1-associated neurodevelopmental disorder ⚠
- p.Thr604Ile Multiple submitters GRID1-associated neurodevelopmental disorder ⚠
- p.Val450Met Multiple submitters GRID1-associated neurodevelopmental disorder ⚠
- p.Ala227Thr Single submitter
- p.Ala236Ser Single submitter GRID1-associated neurodevelopmental disorder ⚠
- p.Ala347Gly Single submitter ⚠
- p.Ala564Thr Single submitter ⚠
- p.Ala571Thr Single submitter ⚠
- p.Ala601Ser Single submitter ⚠
- p.Ala603Val Single submitter ⚠
- p.Ala686Thr Single submitter ⚠
- p.Ala718Ser Single submitter ⚠
- p.Ala817Thr Single submitter GRID1-associated neurodevelopmental disorder ⚠
- p.Ala889Thr Single submitter ⚠
- p.Ala889Val Single submitter ⚠
- p.Arg118His Single submitter GRID1-associated neurodevelopmental disorder
- p.Arg118Leu Single submitter ⚠
- p.Arg148His Single submitter ⚠
- p.Arg161Cys Single submitter GRID1-associated neurodevelopmental disorder ⚠
- p.Arg161His Single submitter ⚠
- p.Arg176His Single submitter ⚠
- p.Arg187Gln Single submitter ⚠
- p.Arg187Trp Single submitter ⚠
- p.Arg225Cys Single submitter ⚠
- p.Arg226Cys Single submitter ⚠
- p.Arg226His Single submitter ⚠
- p.Arg296Trp Single submitter ⚠
- p.Arg300Leu Single submitter GRID1-associated neurodevelopmental disorder ⚠
- p.Arg341Gln Single submitter GRID1-associated neurodevelopmental disorder ⚠
- p.Arg353Gln Single submitter ⚠
- p.Arg363Lys Single submitter ⚠
- p.Arg428Lys Single submitter ⚠
- p.Arg433His Single submitter ⚠
- p.Arg433Ser Single submitter ⚠
- p.Arg491Thr Single submitter ⚠
- p.Arg535Gln Single submitter
- p.Arg585Lys Single submitter ⚠
- p.Arg585Ser Single submitter ⚠
- p.Arg631Cys Single submitter ⚠
- p.Arg631Ser Single submitter ⚠
- p.Arg692Gln Single submitter ⚠
- p.Arg710Gln Single submitter ⚠
- p.Arg859Trp Single submitter ⚠
- p.Arg918Gln Single submitter ⚠
- p.Arg941Gln Single submitter ⚠
- p.Arg977Gln Single submitter ⚠
- p.Asn150Ser Single submitter ⚠
- p.Asn241Ser Single submitter ⚠
- p.Asn715Asp Single submitter ⚠
- p.Asp170Asn Single submitter
- p.Asp290His Single submitter ⚠
- p.Asp489His Single submitter ⚠
- p.Asp684His Single submitter GRID1-associated neurodevelopmental disorder ⚠
- p.Asp798Glu Single submitter ⚠
- p.Cys568Ser Single submitter ⚠
- p.Gln117Glu Single submitter ⚠
- p.Gln74Ter Single submitter GRID1-associated neurodevelopmental disorder
- p.Gln978His Single submitter ⚠
- p.Glu172Lys Single submitter ⚠
- p.Glu447Lys Single submitter GRID1-associated neurodevelopmental disorder ⚠
- p.Glu549Gly Single submitter ⚠
- p.Glu549Lys Single submitter ⚠
- p.Glu707Gly Single submitter GRID1-associated neurodevelopmental disorder
- p.Gly121Arg Single submitter ⚠
- p.Gly136Asp Single submitter GRID1-associated neurodevelopmental disorder ⚠
- p.Gly493Ser Single submitter ⚠
- p.Gly506Arg Single submitter ⚠
- p.Gly542Ala Single submitter
- p.Gly614Val Single submitter ⚠
- p.Gly771Val Single submitter ⚠
- p.Gly906Arg Single submitter ⚠
- p.Gly907Ser Single submitter ⚠
- p.Gly995Asp Single submitter ⚠
- p.His299Asp Single submitter ⚠
- p.His373Gln Single submitter GRID1-associated neurodevelopmental disorder ⚠
- p.His776Gln Single submitter ⚠
- p.His776Tyr Single submitter
- p.Ile175Val Single submitter ⚠
- p.Ile456Leu Single submitter GRID1-associated neurodevelopmental disorder ⚠
- p.Ile505Val Single submitter ⚠
- p.Ile554Phe Single submitter ⚠
- p.Ile632Leu Single submitter ⚠
- p.Ile64Val Single submitter ⚠
- p.Leu190Ile Single submitter ⚠
- p.Leu305Phe Single submitter
- p.Leu425Phe Single submitter ⚠
- p.Leu844Val Single submitter ⚠
- p.Lys199Arg Single submitter GRID1-associated neurodevelopmental disorder ⚠
- p.Lys547Glu Single submitter ⚠
- p.Lys866Arg Single submitter ⚠
- p.Met109Thr Single submitter ⚠
- p.Met167Val Single submitter GRID1-associated neurodevelopmental disorder ⚠
- p.Met504Arg Single submitter ⚠
- p.Met83Leu Single submitter
- p.Phe581Leu Single submitter ⚠
- p.Pro286Leu Single submitter GRID1-associated neurodevelopmental disorder ⚠
- p.Pro390Ser Single submitter ⚠
- p.Pro429Arg Single submitter ⚠
- p.Pro429Thr Single submitter GRID1-associated neurodevelopmental disorder ⚠
- p.Pro488Ser Single submitter ⚠
- p.Pro548Ser Single submitter ⚠
- p.Pro664Leu Single submitter ⚠
- p.Pro952Leu Single submitter GRID1-associated neurodevelopmental disorder ⚠
- p.Pro980Leu Single submitter
- p.Pro984Ser Single submitter GRID1-associated neurodevelopmental disorder ⚠
- p.Pro993Arg Single submitter ⚠
- p.Ser123Trp Single submitter
- p.Ser287Tyr Single submitter ⚠
- p.Ser607Gly Single submitter ⚠
- p.Ser703Asn Single submitter ⚠
- p.Ser757Leu Single submitter ⚠
- p.Ser818Gly Single submitter ⚠
- p.Ser897Leu Single submitter GRID1-associated neurodevelopmental disorder ⚠
- p.Thr206Ile Single submitter ⚠
- p.Thr279Ile Single submitter ⚠
- p.Thr295Ala Single submitter ⚠
- p.Thr295Ser Single submitter ⚠
- p.Thr499Ala Single submitter ⚠
- p.Thr499Asn Single submitter ⚠
- p.Thr641Met Single submitter ⚠
- p.Thr752Met Single submitter GRID1-associated neurodevelopmental disorder ⚠
- p.Thr794Ala Single submitter ⚠
- p.Thr864Ala Single submitter ⚠
- p.Thr864Ile Single submitter ⚠
- p.Trp637Cys Single submitter ⚠
- p.Val166Ile Single submitter GRID1-associated neurodevelopmental disorder ⚠
- p.Val192Ile Single submitter ⚠
- p.Val280Met Single submitter
- p.Val380Ala Single submitter ⚠
- p.Val470Ala Single submitter ⚠
- p.Val565Met Single submitter ⚠
- p.Val589Met Single submitter ⚠
- p.Val617Ile Single submitter ⚠
- p.Val625Met Single submitter ⚠
- p.Ala564Pro No assertion criteria GRID1-related disorder
- p.Thr295Met No assertion criteria prostate cancer ⚠