GRIK3 — 120 ClinVar variants

All ClinVar germline GRIK3 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 102 flagged for review →

1 Conflicting · 8 Benign · 7 Likely benign · 104 Uncertain significance

Full GRIK3 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions

⚑ Evidence disagreements 102

Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.

Predictors agree, ClinVar conflicts 1

ClinVar submitters conflict, but the independent predictors unanimously agree — a QC review flag, not a reclassification.

GRIK3 p.Asp28Glu Conflicting Single submitter

Predictors lean, ClinVar uncertain 75

ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.

Predictors split 26

The independent predictors disagree with each other — read with care.

All GRIK3 variants

Conflicting classifications of pathogenicity 1

p.Asp28Glu Single submitter ⚠

Benign 8

p.Asn151= Multiple submitters
p.Leu188= Multiple submitters
p.Leu269= Multiple submitters
p.Leu470= Multiple submitters
c.1105-4G>A Single submitter
p.Gly276= Single submitter
p.Ser293= Single submitter
p.Tyr156= Single submitter

Likely benign 7

c.2314+8A>T Multiple submitters
c.2565+28A>G Single submitter
p.Ala515= Single submitter
p.Asn722= Single submitter
p.Glu43= Single submitter
p.Ile209Val Single submitter
p.Ser63= Single submitter

Uncertain significance 104

p.Arg423Gln Multiple submitters ⚠
p.Ala266Thr Single submitter ⚠
p.Ala45Glu Single submitter ⚠
p.Ala474Val Single submitter ⚠
p.Ala493Thr Single submitter ⚠
p.Ala782Thr Single submitter
p.Ala815Gly Single submitter ⚠
p.Arg136His Single submitter ⚠
p.Arg205His Single submitter ⚠
p.Arg228Cys Single submitter ⚠
p.Arg228His Single submitter ⚠
p.Arg273Ser Single submitter ⚠
p.Arg309Gln Single submitter ⚠
p.Arg461Gln Single submitter ⚠
p.Arg484Trp Single submitter ⚠
p.Arg636Cys Single submitter ⚠
p.Arg665His Single submitter ⚠
p.Arg6Gln Single submitter ⚠
p.Arg749Lys Single submitter ⚠
p.Arg801Gln Single submitter ⚠
p.Arg801Trp Single submitter ⚠
p.Arg856His Single submitter ⚠
p.Arg867His Single submitter ⚠
p.Arg9Gly Single submitter ⚠
p.Asn126Ser Single submitter ⚠
p.Asn286Ser Single submitter ⚠
p.Asn722Tyr Single submitter ⚠
p.Asp155Asn Single submitter ⚠
p.Asp165Asn Single submitter ⚠
p.Asp213Gly Single submitter ⚠
p.Asp232Asn Single submitter ⚠
p.Asp400Tyr Single submitter ⚠
p.Asp412Asn Single submitter ⚠
p.Asp509Asn Single submitter ⚠
p.Asp777Asn Single submitter ⚠
p.Asp864Asn Single submitter ⚠
p.Gln189Arg Single submitter ⚠
p.Gln819Arg Single submitter ⚠
p.Glu270Asp Single submitter ⚠
p.Glu311Lys Single submitter ⚠
p.Glu463Lys Single submitter ⚠
p.Glu56Lys Single submitter ⚠
p.Glu602Lys Single submitter ⚠
p.Glu797Lys Single submitter ⚠
p.Gly111Ser Single submitter ⚠
p.Gly18Arg Single submitter ⚠
p.Gly224Ser Single submitter ⚠
p.Gly313Ser Single submitter ⚠
p.His161Arg Single submitter ⚠
p.His34Gln Single submitter ⚠
p.Ile163Val Single submitter ⚠
p.Ile38Leu Single submitter ⚠
p.Ile394Val Single submitter ⚠
p.Ile476Val Single submitter ⚠
p.Ile638Thr Single submitter ⚠
p.Ile682Val Single submitter ⚠
p.Leu207Phe Single submitter ⚠
p.Leu217Ser Single submitter ⚠
p.Leu314Gln Single submitter ⚠
p.Leu315Arg Single submitter ⚠
p.Leu834Val Single submitter ⚠
p.Leu8Phe Single submitter ⚠
p.Leu914Val Single submitter ⚠
p.Lys219delinsAsnTer Single submitter GRIK3-related disorder
p.Lys700Arg Single submitter ⚠
p.Lys849Arg Single submitter ⚠
p.Met193Ile Single submitter ⚠
p.Met448Thr Single submitter ⚠
p.Met503Ile Single submitter ⚠
p.Met567Ile Single submitter ⚠
p.Phe24Leu Single submitter ⚠
p.Pro883Ala Single submitter ⚠
p.Ser182Asn Single submitter ⚠
p.Ser234Ile Single submitter ⚠
p.Ser716Trp Single submitter ⚠
p.Ser803Gly Single submitter ⚠
p.Ser803Ile Single submitter ⚠
p.Ser814Asn Single submitter ⚠
p.Ser814Thr Single submitter ⚠
p.Ser860Arg Single submitter ⚠
p.Thr183Ala Single submitter ⚠
p.Thr344Asn Single submitter
p.Thr522Asn Single submitter ⚠
p.Thr522Ser Single submitter ⚠
p.Thr662Ile Single submitter ⚠
p.Thr731Ala Single submitter ⚠
p.Thr731Ser Single submitter ⚠
p.Thr871Ile Single submitter ⚠
p.Tyr255Cys Single submitter ⚠
p.Tyr481Cys Single submitter ⚠
p.Tyr481Phe Single submitter ⚠
p.Tyr775Phe Single submitter ⚠
p.Val121Ile Single submitter ⚠
p.Val178Leu Single submitter ⚠
p.Val277Met Single submitter ⚠
p.Val292Ile Single submitter ⚠
p.Val419Phe Single submitter ⚠
p.Val582Ile Single submitter ⚠
p.Val663Met Single submitter ⚠
p.Val833Gly Single submitter ⚠
p.Val886Ala Single submitter ⚠
p.Val886Ile Single submitter ⚠
p.Val891Ile Single submitter ⚠
p.Val917Leu Single submitter ⚠