GRIK4 — 164 ClinVar variants

All ClinVar germline GRIK4 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 113 flagged for review →

12 Benign · 1 Benign/Likely benign · 26 Likely benign · 125 Uncertain significance

Full GRIK4 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions

⚑ Evidence disagreements 113

Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.

Predictors lean, ClinVar uncertain 90

ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.

Predictors split 23

The independent predictors disagree with each other — read with care.

All GRIK4 variants

Benign 12

p.Ala167Gly Multiple submitters
p.Gln607= Multiple submitters
p.His218= Multiple submitters
p.His23Gln Multiple submitters
p.Leu95= Multiple submitters
p.Met824Thr Multiple submitters
p.Tyr374= Multiple submitters
p.Val528Ile Multiple submitters
c.83-10039T>C Single submitter
p.Glu76= Single submitter
p.Ile265Val Single submitter
p.Val419= Single submitter

Benign/Likely benign 1

p.His343= Multiple submitters

Likely benign 26

c.691-9G>A Multiple submitters
p.Ser305= Multiple submitters
p.Ser5= Multiple submitters
p.Thr212= Multiple submitters
c.2266+7G>A Single submitter
c.2267-4G>A Single submitter
c.2395+18_2395+22dup Single submitter
c.346-12T>C Single submitter
p.Ala13= Single submitter
p.Ala213= Single submitter
p.Ala276= Single submitter
p.Ala866= Single submitter
p.Arg387= Single submitter
p.Arg58= Single submitter
p.Asn479= Single submitter
p.Cys893= Single submitter
p.Gln326= Single submitter
p.His671= Single submitter
p.Ile328= Single submitter
p.Leu15= Single submitter
p.Leu776= Single submitter
p.Met690Ile Single submitter ⚠
p.Ser337= Single submitter
p.Ser44= Single submitter
p.Ser700= Single submitter
p.Thr161= Single submitter

Uncertain significance 125

p.Ala13Val Single submitter ⚠
p.Ala169Glu Single submitter ⚠
p.Ala169Thr Single submitter ⚠
p.Ala19Thr Single submitter ⚠
p.Ala338Gly Single submitter ⚠
p.Ala491Thr Single submitter ⚠
p.Ala554Val Single submitter ⚠
p.Ala55Thr Single submitter ⚠
p.Ala664Thr Single submitter ⚠
p.Ala6Val Single submitter ⚠
p.Ala711Thr Single submitter ⚠
p.Ala866Thr Single submitter ⚠
p.Ala885Glu Single submitter ⚠
p.Ala895Glu Single submitter ⚠
p.Ala902Thr Single submitter ⚠
p.Ala938Val Single submitter ⚠
p.Ala93Thr Single submitter ⚠
p.Arg192Ser Single submitter ⚠
p.Arg208Trp Single submitter ⚠
p.Arg262Gly Single submitter ⚠
p.Arg352Cys Single submitter ⚠
p.Arg352Leu Single submitter ⚠
p.Arg42Trp Single submitter ⚠
p.Arg466His Single submitter ⚠
p.Arg466Leu Single submitter ⚠
p.Arg51Cys Single submitter
p.Arg51Ser Single submitter ⚠
p.Arg527Cys Single submitter ⚠
p.Arg532Pro Single submitter
p.Arg54Cys Single submitter
p.Arg54His Single submitter ⚠
p.Arg567Trp Single submitter ⚠
p.Arg619His Single submitter ⚠
p.Arg683His Single submitter ⚠
p.Arg781His Single submitter ⚠
p.Arg872Gln Single submitter ⚠
p.Arg872Gly Single submitter ⚠
p.Arg880Pro Single submitter ⚠
p.Arg926Leu Single submitter ⚠
p.Arg927Cys Single submitter
p.Arg934Leu Single submitter ⚠
p.Arg939Cys Single submitter ⚠
p.Arg939Leu Single submitter ⚠
p.Asn155Tyr Single submitter ⚠
p.Asn264Ser Single submitter ⚠
p.Asn286Lys Single submitter ⚠
p.Asn462Lys Single submitter ⚠
p.Asn53His Single submitter ⚠
p.Asn53Ser Single submitter ⚠
p.Asn717Ser Single submitter ⚠
p.Asn889Lys Single submitter ⚠
p.Asp195Gly Single submitter
p.Asp32Asn Single submitter ⚠
p.Asp411Gly Single submitter ⚠
p.Asp899Asn Single submitter ⚠
p.Cys163Arg Single submitter ⚠
p.Gln290Arg Single submitter ⚠
p.Gln739His Single submitter ⚠
p.Glu176Lys Single submitter ⚠
p.Glu206Asp Single submitter ⚠
p.Glu233Gly Single submitter
p.Glu572Lys Single submitter ⚠
p.Glu762Lys Single submitter
p.Glu835Gly Single submitter ⚠
p.Glu897Lys Single submitter ⚠
p.Glu945Gln Single submitter ⚠
p.Glu954Lys Single submitter ⚠
p.Glu956Ala Single submitter ⚠
p.Gly329Ser Single submitter ⚠
p.Gly608Val Single submitter ⚠
p.His140Gln Single submitter ⚠
p.His393Arg Single submitter ⚠
p.Ile340Val Single submitter ⚠
p.Ile710Val Single submitter ⚠
p.Ile767Val Single submitter ⚠
p.Ile817Met Single submitter ⚠
p.Ile820Thr Single submitter ⚠
p.Ile852Val Single submitter ⚠
p.Leu183Arg Single submitter ⚠
p.Leu307Met Single submitter ⚠
p.Leu552Phe Single submitter ⚠
p.Leu8Val Single submitter ⚠
p.Leu905_Glu908del Single submitter
p.Lys704Glu Single submitter
p.Lys791Arg Single submitter ⚠
p.Met400Val Single submitter ⚠
p.Met605Thr Single submitter ⚠
p.Met605Val Single submitter ⚠
p.Met822Ile Single submitter ⚠
p.Met845Ile Single submitter ⚠
p.Met845Leu Single submitter
p.Phe129Ser Single submitter ⚠
p.Phe298Leu Single submitter ⚠
p.Phe386Ser Single submitter ⚠
p.Phe69Cys Single submitter ⚠
p.Pro301Ser Single submitter ⚠
p.Pro7Leu Single submitter ⚠
p.Pro861Leu Single submitter ⚠
p.Pro876Ser Single submitter ⚠
p.Pro937Ser Single submitter ⚠
p.Ser257Asn Single submitter ⚠
p.Ser407Phe Single submitter ⚠
p.Ser514Phe Single submitter ⚠
p.Ser622Asn Single submitter ⚠
p.Ser700Arg Single submitter ⚠
p.Ser98Leu Single submitter ⚠
p.Thr144Ser Single submitter ⚠
p.Thr201Ile Single submitter ⚠
p.Thr242Lys Single submitter ⚠
p.Thr519Ile Single submitter ⚠
p.Thr637Met Single submitter ⚠
p.Thr677Ile Single submitter
p.Thr746Ala Single submitter
p.Thr884Met Single submitter ⚠
p.Tyr718Ser Single submitter ⚠
p.Val16Met Single submitter ⚠
p.Val191Ile Single submitter ⚠
p.Val312Phe Single submitter ⚠
p.Val330Met Single submitter ⚠
p.Val394Met Single submitter ⚠
p.Val468Ala Single submitter ⚠
p.Val558Ile Single submitter
p.Val646Met Single submitter ⚠
p.Val818Met Single submitter ⚠
p.Val846Met Single submitter ⚠