GRIK5 — 131 ClinVar variants
All ClinVar germline GRIK5 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 109 flagged for review →
3 Benign · 14 Likely benign · 114 Uncertain significance
Full GRIK5 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 109
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 72
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- GRIK5 p.Val839Leu Uncertain significance Multiple submitters
- GRIK5 p.Ala134Thr Uncertain significance Single submitter
- GRIK5 p.Ala294Gly Uncertain significance Single submitter
- GRIK5 p.Ala944Thr Uncertain significance Single submitter
- GRIK5 p.Arg197Gln Uncertain significance Single submitter
- GRIK5 p.Arg197Gly Uncertain significance Single submitter
- GRIK5 p.Arg25Cys Uncertain significance Single submitter
- GRIK5 p.Arg361Gln Uncertain significance Single submitter
- GRIK5 p.Arg382Gln Uncertain significance Single submitter
- GRIK5 p.Arg38His Uncertain significance Single submitter
- GRIK5 p.Arg459His Uncertain significance Single submitter
- GRIK5 p.Arg465Gln Uncertain significance Single submitter
- GRIK5 p.Arg582Cys Uncertain significance Single submitter
- GRIK5 p.Arg613Gly Uncertain significance Single submitter
- GRIK5 p.Arg62Gln Uncertain significance Single submitter
- GRIK5 p.Arg711Cys Uncertain significance Single submitter
- GRIK5 p.Arg730Gln Uncertain significance Single submitter
- GRIK5 p.Arg832Ser Uncertain significance Single submitter
- GRIK5 p.Arg856His Uncertain significance Single submitter
- GRIK5 p.Arg856Leu Uncertain significance Single submitter
- GRIK5 p.Arg863Pro Uncertain significance Single submitter
- GRIK5 p.Arg974Gln Uncertain significance Single submitter
- GRIK5 p.Asn322Ser Uncertain significance Single submitter
- GRIK5 p.Asn407Ser Uncertain significance Single submitter
- GRIK5 p.Asn52Ser Uncertain significance Single submitter
- GRIK5 p.Asp260Asn Uncertain significance Single submitter
- GRIK5 p.Asp80Asn Uncertain significance Single submitter
- GRIK5 p.Gln435Arg Uncertain significance Single submitter
- GRIK5 p.Glu456Lys Uncertain significance Single submitter
- GRIK5 p.Glu56Lys Uncertain significance Single submitter
- GRIK5 p.Glu69Gln Uncertain significance Single submitter
- GRIK5 p.Glu978Asp Uncertain significance Single submitter
- GRIK5 p.Gly747Asp Uncertain significance Single submitter
- GRIK5 p.Gly785Glu Uncertain significance Single submitter
- GRIK5 p.Gly914Arg Uncertain significance Single submitter
- GRIK5 p.His117Leu Uncertain significance Single submitter
- GRIK5 p.His979Tyr Uncertain significance Single submitter
- GRIK5 p.Ile118Val Uncertain significance Single submitter
- GRIK5 p.Ile388Val Uncertain significance Single submitter
- GRIK5 p.Ile54Val Uncertain significance Single submitter
- GRIK5 p.Ile766Val Uncertain significance Single submitter
- GRIK5 p.Leu128Phe Uncertain significance Single submitter
- GRIK5 p.Leu147Phe Uncertain significance Single submitter
- GRIK5 p.Leu227Ile Uncertain significance Single submitter
- GRIK5 p.Leu417Pro Uncertain significance Single submitter
- GRIK5 p.Leu942Arg Uncertain significance Single submitter
- GRIK5 p.Met247Val Uncertain significance Single submitter
- GRIK5 p.Pro126Ser Uncertain significance Single submitter
- GRIK5 p.Pro126Thr Uncertain significance Single submitter
- GRIK5 p.Pro2Leu Uncertain significance Single submitter
- GRIK5 p.Pro2Ser Uncertain significance Single submitter
- GRIK5 p.Pro867Thr Uncertain significance Single submitter
- GRIK5 p.Pro87Ala Uncertain significance Single submitter
- GRIK5 p.Pro924Ser Uncertain significance Single submitter
- GRIK5 p.Pro926His Uncertain significance Single submitter
- GRIK5 p.Pro973Thr Uncertain significance Single submitter
- GRIK5 p.Ser231Leu Uncertain significance Single submitter
- GRIK5 p.Ser756Phe Uncertain significance Single submitter
- GRIK5 p.Ser854Ala Uncertain significance Single submitter
- GRIK5 p.Ser854Cys Uncertain significance Single submitter
- GRIK5 p.Ser854Thr Uncertain significance Single submitter
- GRIK5 p.Ser892Leu Uncertain significance Single submitter
- GRIK5 p.Ser917Ile Uncertain significance Single submitter
- GRIK5 p.Ser945Leu Uncertain significance Single submitter
- GRIK5 p.Thr272Ala Uncertain significance Single submitter
- GRIK5 p.Thr272Met Uncertain significance Single submitter
- GRIK5 p.Val145Ile Uncertain significance Single submitter
- GRIK5 p.Val841Leu Uncertain significance Single submitter
- GRIK5 p.Val841Met Uncertain significance Single submitter
- GRIK5 p.Val930Leu Uncertain significance Single submitter
-
GRIK5 p.Ala161Ser
Uncertain significance
No assertion criteria
GRIK5-related disorder
-
GRIK5 p.His253Tyr
Uncertain significance
No assertion criteria
GRIK5-related disorder
Predictors split 37
The independent predictors disagree with each other — read with care.
- GRIK5 p.Arg832Met Benign Multiple submitters
- GRIK5 p.Ala134Val Uncertain significance Single submitter
- GRIK5 p.Ala310Thr Uncertain significance Single submitter
- GRIK5 p.Ala718Val Uncertain significance Single submitter
- GRIK5 p.Arg207His Uncertain significance Single submitter
- GRIK5 p.Arg386Cys Uncertain significance Single submitter
- GRIK5 p.Arg459Cys Uncertain significance Single submitter
- GRIK5 p.Arg463Cys Uncertain significance Single submitter
- GRIK5 p.Arg465Trp Uncertain significance Single submitter
- GRIK5 p.Arg580Trp Uncertain significance Single submitter
- GRIK5 p.Arg716Cys Uncertain significance Single submitter
-
GRIK5 p.Arg787Trp
Uncertain significance
Single submitter
GRIK5-related disorder
- GRIK5 p.Arg937Gly Uncertain significance Single submitter
- GRIK5 p.Asn285Thr Uncertain significance Single submitter
- GRIK5 p.Asn414Lys Uncertain significance Single submitter
- GRIK5 p.Asn490Lys Uncertain significance Single submitter
- GRIK5 p.Asp80Tyr Uncertain significance Single submitter
- GRIK5 p.Cys855Trp Uncertain significance Single submitter
-
GRIK5 p.Glu476Lys
Uncertain significance
Single submitter
GRIK5-related disorder
- GRIK5 p.Glu77Lys Uncertain significance Single submitter
- GRIK5 p.Glu882Lys Uncertain significance Single submitter
- GRIK5 p.Gly602Ser Uncertain significance Single submitter
- GRIK5 p.His274Gln Uncertain significance Single submitter
- GRIK5 p.His929Tyr Uncertain significance Single submitter
- GRIK5 p.Ile939Ser Uncertain significance Single submitter
- GRIK5 p.Met82Ile Uncertain significance Single submitter
- GRIK5 p.Phe249Ile Uncertain significance Single submitter
- GRIK5 p.Pro275Leu Uncertain significance Single submitter
- GRIK5 p.Ser324Gly Uncertain significance Single submitter
- GRIK5 p.Thr79Met Uncertain significance Single submitter
- GRIK5 p.Thr81Ile Uncertain significance Single submitter
- GRIK5 p.Tyr158Cys Uncertain significance Single submitter
- GRIK5 p.Tyr535Cys Uncertain significance Single submitter
-
GRIK5 p.Val106Leu
Uncertain significance
Single submitter
GRIK5-related disorder
- GRIK5 p.Val311Leu Uncertain significance Single submitter
- GRIK5 p.Val546Met Uncertain significance Single submitter
-
GRIK5 p.Met352Val
Likely benign
No assertion criteria
GRIK5-related disorder
All GRIK5 variants
Benign 3
- p.Arg832Met Multiple submitters ⚠
- p.Tyr692= Multiple submitters
- c.904-5C>T No assertion criteria GRIK5-related disorder
Likely benign 14
- c.2514+908G>A Single submitter
- p.Ala902= Single submitter
- p.Asn440= Single submitter
- p.Asp144= Single submitter
- p.Gly389= Single submitter
- c.2263+9C>T No assertion criteria GRIK5-related disorder
- c.2514+884C>G No assertion criteria GRIK5-related disorder
- p.Ala581Val No assertion criteria GRIK5-related disorder
- p.Asn219= No assertion criteria GRIK5-related disorder
- p.Glu124= No assertion criteria GRIK5-related disorder
- p.His342= No assertion criteria GRIK5-related disorder
- p.His670= No assertion criteria GRIK5-related disorder
- p.Met352Val No assertion criteria GRIK5-related disorder ⚠
- p.Ser261Phe No assertion criteria GRIK5-related disorder
Uncertain significance 114
- p.Val839Leu Multiple submitters ⚠
- c.342+2T>C Single submitter
- p.Ala134Thr Single submitter ⚠
- p.Ala134Val Single submitter ⚠
- p.Ala294Gly Single submitter ⚠
- p.Ala310Thr Single submitter ⚠
- p.Ala718Val Single submitter ⚠
- p.Ala944Thr Single submitter ⚠
- p.Arg197Gln Single submitter ⚠
- p.Arg197Gly Single submitter ⚠
- p.Arg207His Single submitter ⚠
- p.Arg25Cys Single submitter ⚠
- p.Arg361Gln Single submitter ⚠
- p.Arg382Gln Single submitter ⚠
- p.Arg386Cys Single submitter ⚠
- p.Arg38His Single submitter ⚠
- p.Arg459Cys Single submitter ⚠
- p.Arg459His Single submitter ⚠
- p.Arg463Cys Single submitter ⚠
- p.Arg465Gln Single submitter ⚠
- p.Arg465Trp Single submitter ⚠
- p.Arg580Trp Single submitter ⚠
- p.Arg582Cys Single submitter ⚠
- p.Arg613Gly Single submitter ⚠
- p.Arg62Gln Single submitter ⚠
- p.Arg711Cys Single submitter ⚠
- p.Arg716Cys Single submitter ⚠
- p.Arg730Gln Single submitter ⚠
- p.Arg787Trp Single submitter GRIK5-related disorder ⚠
- p.Arg832Ser Single submitter ⚠
- p.Arg856His Single submitter ⚠
- p.Arg856Leu Single submitter ⚠
- p.Arg863Pro Single submitter ⚠
- p.Arg937Gly Single submitter ⚠
- p.Arg974Gln Single submitter ⚠
- p.Asn285Thr Single submitter ⚠
- p.Asn322Ser Single submitter ⚠
- p.Asn407Ser Single submitter ⚠
- p.Asn414Lys Single submitter ⚠
- p.Asn490Lys Single submitter ⚠
- p.Asn52Ser Single submitter ⚠
- p.Asp260Asn Single submitter ⚠
- p.Asp80Asn Single submitter ⚠
- p.Asp80Tyr Single submitter ⚠
- p.Cys855Trp Single submitter ⚠
- p.Gln435Arg Single submitter ⚠
- p.Glu456Lys Single submitter ⚠
- p.Glu476Lys Single submitter GRIK5-related disorder ⚠
- p.Glu56Lys Single submitter ⚠
- p.Glu69Gln Single submitter ⚠
- p.Glu77Lys Single submitter ⚠
- p.Glu882Lys Single submitter ⚠
- p.Glu978Asp Single submitter ⚠
- p.Gly39Ser Single submitter
- p.Gly602Ser Single submitter ⚠
- p.Gly747Asp Single submitter ⚠
- p.Gly785Arg Single submitter
- p.Gly785Glu Single submitter ⚠
- p.Gly914Arg Single submitter ⚠
- p.His117Leu Single submitter ⚠
- p.His274Gln Single submitter ⚠
- p.His929Tyr Single submitter ⚠
- p.His979Tyr Single submitter ⚠
- p.Ile118Val Single submitter ⚠
- p.Ile388Val Single submitter ⚠
- p.Ile54Val Single submitter ⚠
- p.Ile766Val Single submitter ⚠
- p.Ile939Ser Single submitter ⚠
- p.Leu128Phe Single submitter ⚠
- p.Leu147Phe Single submitter ⚠
- p.Leu227Ile Single submitter ⚠
- p.Leu417Pro Single submitter ⚠
- p.Leu942Arg Single submitter ⚠
- p.Met247Val Single submitter ⚠
- p.Met550Val Single submitter
- p.Met82Ile Single submitter ⚠
- p.Phe249Ile Single submitter ⚠
- p.Pro126Ser Single submitter ⚠
- p.Pro126Thr Single submitter ⚠
- p.Pro275Leu Single submitter ⚠
- p.Pro2Leu Single submitter ⚠
- p.Pro2Ser Single submitter ⚠
- p.Pro867Thr Single submitter ⚠
- p.Pro87Ala Single submitter ⚠
- p.Pro924Ser Single submitter ⚠
- p.Pro926His Single submitter ⚠
- p.Pro973Thr Single submitter ⚠
- p.Ser231Leu Single submitter ⚠
- p.Ser324Gly Single submitter ⚠
- p.Ser756Phe Single submitter ⚠
- p.Ser854Ala Single submitter ⚠
- p.Ser854Cys Single submitter ⚠
- p.Ser854Thr Single submitter ⚠
- p.Ser892Leu Single submitter ⚠
- p.Ser917Ile Single submitter ⚠
- p.Ser945Leu Single submitter ⚠
- p.Thr272Ala Single submitter ⚠
- p.Thr272Met Single submitter ⚠
- p.Thr79Met Single submitter ⚠
- p.Thr81Ile Single submitter ⚠
- p.Tyr130His Single submitter
- p.Tyr158Cys Single submitter ⚠
- p.Tyr535Cys Single submitter ⚠
- p.Val106Leu Single submitter GRIK5-related disorder ⚠
- p.Val145Ile Single submitter ⚠
- p.Val311Leu Single submitter ⚠
- p.Val546Met Single submitter ⚠
- p.Val712Ile Single submitter
- p.Val841Leu Single submitter ⚠
- p.Val841Met Single submitter ⚠
- p.Val930Leu Single submitter ⚠
- p.Ala161Ser No assertion criteria GRIK5-related disorder ⚠
- p.Ala301= No assertion criteria GRIK5-related disorder
- p.His253Tyr No assertion criteria GRIK5-related disorder ⚠