GRIN2C — 180 ClinVar variants
All ClinVar germline GRIN2C variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 141 flagged for review →
6 Benign · 2 Benign/Likely benign · 18 Likely benign · 154 Uncertain significance
Full GRIN2C gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 141
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 113
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- GRIN2C p.Ala241Thr Uncertain significance Single submitter
- GRIN2C p.Ala267Thr Uncertain significance Single submitter
- GRIN2C p.Ala312Val Uncertain significance Single submitter
- GRIN2C p.Ala4Thr Uncertain significance Single submitter
- GRIN2C p.Ala503Glu Uncertain significance Single submitter
- GRIN2C p.Ala536Thr Uncertain significance Single submitter
- GRIN2C p.Ala596Thr Uncertain significance Single submitter
- GRIN2C p.Ala714Val Uncertain significance Single submitter
- GRIN2C p.Ala929Val Uncertain significance Single submitter
- GRIN2C p.Ala968Val Uncertain significance Single submitter
- GRIN2C p.Arg183His Uncertain significance Single submitter
- GRIN2C p.Arg282His Uncertain significance Single submitter
- GRIN2C p.Arg290His Uncertain significance Single submitter
- GRIN2C p.Arg328Trp Uncertain significance Single submitter
- GRIN2C p.Arg374Leu Uncertain significance Single submitter
- GRIN2C p.Arg434Cys Uncertain significance Single submitter
- GRIN2C p.Arg488Gly Uncertain significance Single submitter
- GRIN2C p.Arg49Cys Uncertain significance Single submitter
- GRIN2C p.Arg537Cys Uncertain significance Single submitter
- GRIN2C p.Arg690Gln Uncertain significance Single submitter
- GRIN2C p.Arg771Trp Uncertain significance Single submitter
- GRIN2C p.Arg861Gly Uncertain significance Single submitter
- GRIN2C p.Arg878Leu Uncertain significance Single submitter
- GRIN2C p.Arg901Cys Uncertain significance Single submitter
- GRIN2C p.Arg939Gln Uncertain significance Single submitter
- GRIN2C p.Arg939Trp Uncertain significance Single submitter
- GRIN2C p.Asn685Ser Uncertain significance Single submitter
- GRIN2C p.Asp344Asn Uncertain significance Single submitter
- GRIN2C p.Asp399His Uncertain significance Single submitter
- GRIN2C p.Asp658Asn Uncertain significance Single submitter
- GRIN2C p.Asp698Gly Uncertain significance Single submitter
- GRIN2C p.Asp883Asn Uncertain significance Single submitter
- GRIN2C p.Asp964His Uncertain significance Single submitter
- GRIN2C p.Gln287Arg Uncertain significance Single submitter
- GRIN2C p.Gln28Pro Uncertain significance Single submitter
- GRIN2C p.Gln53Glu Uncertain significance Single submitter
- GRIN2C p.Glu134Ala Uncertain significance Single submitter
- GRIN2C p.Glu147Lys Uncertain significance Single submitter
- GRIN2C p.Glu180Lys Uncertain significance Single submitter
- GRIN2C p.Glu231Lys Uncertain significance Single submitter
- GRIN2C p.Glu921Lys Uncertain significance Single submitter
- GRIN2C p.Glu954Gly Uncertain significance Single submitter
- GRIN2C p.Gly143Ser Uncertain significance Single submitter
- GRIN2C p.Gly16Ser Uncertain significance Single submitter
- GRIN2C p.Gly206Ala Uncertain significance Single submitter
- GRIN2C p.Gly22Asp Uncertain significance Single submitter
- GRIN2C p.Gly292Val Uncertain significance Single submitter
- GRIN2C p.Gly29Asp Uncertain significance Single submitter
- GRIN2C p.Gly2Cys Uncertain significance Single submitter
- GRIN2C p.Gly2Ser Uncertain significance Single submitter
- GRIN2C p.Gly322Arg Uncertain significance Single submitter
- GRIN2C p.Gly350Asp Uncertain significance Single submitter
- GRIN2C p.Gly425Asp Uncertain significance Single submitter
- GRIN2C p.Gly540Ser Uncertain significance Single submitter
- GRIN2C p.Gly593Arg Uncertain significance Single submitter
- GRIN2C p.Gly941Ser Uncertain significance Single submitter
- GRIN2C p.Gly965Glu Uncertain significance Single submitter
- GRIN2C p.Gly985Arg Uncertain significance Single submitter
- GRIN2C p.His116Asn Uncertain significance Single submitter
- GRIN2C p.His190Arg Uncertain significance Single submitter
- GRIN2C p.Ile569Val Uncertain significance Single submitter
- GRIN2C p.Ile657Val Uncertain significance Single submitter
- GRIN2C p.Ile812Val Uncertain significance Single submitter
- GRIN2C p.Leu733Val Uncertain significance Single submitter
- GRIN2C p.Leu745Pro Uncertain significance Single submitter
- GRIN2C p.Lys501Arg Uncertain significance Single submitter
- GRIN2C p.Lys722Arg Uncertain significance Single submitter
- GRIN2C p.Lys752Arg Uncertain significance Single submitter
- GRIN2C p.Met358Val Uncertain significance Single submitter
- GRIN2C p.Met534Thr Uncertain significance Single submitter
- GRIN2C p.Phe224Val Uncertain significance Single submitter
- GRIN2C p.Phe819Tyr Uncertain significance Single submitter
- GRIN2C p.Pro173Gln Uncertain significance Single submitter
- GRIN2C p.Pro313Leu Uncertain significance Single submitter
- GRIN2C p.Pro323Ser Uncertain significance Single submitter
- GRIN2C p.Pro421Ser Uncertain significance Single submitter
- GRIN2C p.Pro42His Uncertain significance Single submitter
- GRIN2C p.Pro52Ser Uncertain significance Single submitter
- GRIN2C p.Pro579Leu Uncertain significance Single submitter
- GRIN2C p.Pro671Leu Uncertain significance Single submitter
- GRIN2C p.Pro7Leu Uncertain significance Single submitter
- GRIN2C p.Pro882Leu Uncertain significance Single submitter
- GRIN2C p.Pro938Ala Uncertain significance Single submitter
- GRIN2C p.Pro953Arg Uncertain significance Single submitter
- GRIN2C p.Pro953Gln Uncertain significance Single submitter
- GRIN2C p.Pro955Ser Uncertain significance Single submitter
- GRIN2C p.Pro962Leu Uncertain significance Single submitter
- GRIN2C p.Pro978Gln Uncertain significance Single submitter
- GRIN2C p.Ser346Phe Uncertain significance Single submitter
- GRIN2C p.Ser418Gly Uncertain significance Single submitter
- GRIN2C p.Ser54Asn Uncertain significance Single submitter
- GRIN2C p.Ser875Arg Uncertain significance Single submitter
- GRIN2C p.Ser875Thr Uncertain significance Single submitter
- GRIN2C p.Ser912Phe Uncertain significance Single submitter
- GRIN2C p.Thr131Asn Uncertain significance Single submitter
- GRIN2C p.Thr262Ile Uncertain significance Single submitter
- GRIN2C p.Thr404Met Uncertain significance Single submitter
- GRIN2C p.Thr450Asn Uncertain significance Single submitter
- GRIN2C p.Thr644Met Uncertain significance Single submitter
- GRIN2C p.Thr682Met Uncertain significance Single submitter
- GRIN2C p.Thr72Ala Uncertain significance Single submitter
- GRIN2C p.Tyr582His Uncertain significance Single submitter
- GRIN2C p.Tyr656Asn Uncertain significance Single submitter
- GRIN2C p.Val144Ala Uncertain significance Single submitter
- GRIN2C p.Val152Met Uncertain significance Single submitter
- GRIN2C p.Val182Gly Uncertain significance Single submitter
- GRIN2C p.Val223Leu Uncertain significance Single submitter
- GRIN2C p.Val223Met Uncertain significance Single submitter
- GRIN2C p.Val324Ile Uncertain significance Single submitter
- GRIN2C p.Val414Leu Uncertain significance Single submitter
- GRIN2C p.Val67Ile Uncertain significance Single submitter
- GRIN2C p.Val69Ile Uncertain significance Single submitter
- GRIN2C p.Val971Leu Uncertain significance Single submitter
Predictors split 28
The independent predictors disagree with each other — read with care.
- GRIN2C p.Ala466Gly Uncertain significance Single submitter
- GRIN2C p.Ala858Gly Uncertain significance Single submitter
- GRIN2C p.Arg211Pro Uncertain significance Single submitter
- GRIN2C p.Arg305Cys Uncertain significance Single submitter
- GRIN2C p.Arg365Trp Uncertain significance Single submitter
- GRIN2C p.Arg401Trp Uncertain significance Single submitter
- GRIN2C p.Arg435Met Uncertain significance Single submitter
- GRIN2C p.Arg670Gln Uncertain significance Single submitter
- GRIN2C p.Arg709Cys Uncertain significance Single submitter
- GRIN2C p.Arg844Cys Uncertain significance Single submitter
- GRIN2C p.Arg844His Uncertain significance Single submitter
- GRIN2C p.Gln141Pro Uncertain significance Single submitter
- GRIN2C p.Gln584Lys Uncertain significance Single submitter
- GRIN2C p.Gln674Glu Uncertain significance Single submitter
- GRIN2C p.Gln764Arg Uncertain significance Single submitter
- GRIN2C p.Glu741Gln Uncertain significance Single submitter
- GRIN2C p.Gly181Val Uncertain significance Single submitter
- GRIN2C p.Gly244Ala Uncertain significance Single submitter
- GRIN2C p.Gly489Ser Uncertain significance Single submitter
- GRIN2C p.Ile459Met Uncertain significance Single submitter
- GRIN2C p.Leu146Pro Uncertain significance Single submitter
- GRIN2C p.Leu195Pro Uncertain significance Single submitter
- GRIN2C p.Met763Thr Uncertain significance Single submitter
- GRIN2C p.Phe237Leu Uncertain significance Single submitter
- GRIN2C p.Phe577Val Uncertain significance Single submitter
- GRIN2C p.Ser229Leu Uncertain significance Single submitter
- GRIN2C p.Thr51Ile Uncertain significance Single submitter
- GRIN2C p.Val571Ile Uncertain significance Single submitter
All GRIN2C variants
Benign 6
- p.Arg401Gln Multiple submitters
- p.Arg435= Multiple submitters
- p.Thr1196Ile Multiple submitters
- c.400-11dup Single submitter
- p.Ala33= Single submitter
- p.His1187_Gly1193del No assertion criteria GRIN2C-related disorder
Benign/Likely benign 2
- p.Ile519= Multiple submitters
- p.Val490Ile Multiple submitters
Likely benign 18
- p.Ala8Thr Multiple submitters
- p.Ala999= Multiple submitters
- p.Leu65Phe Multiple submitters
- p.Val191Ala Multiple submitters
- p.Ala776= Single submitter
- p.Arg183= Single submitter
- p.Arg47His Single submitter
- p.Arg488= Single submitter
- p.Phe680= Single submitter
- p.Ser302Gly Single submitter
- p.Ser795= Single submitter
- p.Ser887Gly Single submitter
- p.Thr131Ser Single submitter
- p.Tyr759= Single submitter
- p.Gly1110Ala No assertion criteria GRIN2C-related disorder
- p.Gly1189_Arg1190insGlyProLeuGlyHisArgGly No assertion criteria GRIN2C-related disorder
- p.Gly20Arg No assertion criteria GRIN2C-related disorder
- p.His1111Gln No assertion criteria GRIN2C-related disorder
Uncertain significance 154
- p.Ala233Thr Single submitter
- p.Ala241Thr Single submitter ⚠
- p.Ala267Thr Single submitter ⚠
- p.Ala312Val Single submitter ⚠
- p.Ala466Gly Single submitter ⚠
- p.Ala4Thr Single submitter ⚠
- p.Ala503Glu Single submitter ⚠
- p.Ala536Thr Single submitter ⚠
- p.Ala596Thr Single submitter ⚠
- p.Ala714Val Single submitter ⚠
- p.Ala858Gly Single submitter ⚠
- p.Ala929Val Single submitter ⚠
- p.Ala968Val Single submitter ⚠
- p.Arg183His Single submitter ⚠
- p.Arg211Pro Single submitter ⚠
- p.Arg282His Single submitter ⚠
- p.Arg290His Single submitter ⚠
- p.Arg305Cys Single submitter ⚠
- p.Arg328Trp Single submitter ⚠
- p.Arg365Trp Single submitter ⚠
- p.Arg374Leu Single submitter ⚠
- p.Arg401Trp Single submitter ⚠
- p.Arg411Trp Single submitter
- p.Arg434Cys Single submitter ⚠
- p.Arg434His Single submitter
- p.Arg435Met Single submitter ⚠
- p.Arg488Gly Single submitter ⚠
- p.Arg49Cys Single submitter ⚠
- p.Arg537Cys Single submitter ⚠
- p.Arg670Gln Single submitter ⚠
- p.Arg679His Single submitter
- p.Arg690Gln Single submitter ⚠
- p.Arg709Cys Single submitter ⚠
- p.Arg771Trp Single submitter ⚠
- p.Arg844Cys Single submitter ⚠
- p.Arg844His Single submitter ⚠
- p.Arg861Gly Single submitter ⚠
- p.Arg878Leu Single submitter ⚠
- p.Arg901Cys Single submitter ⚠
- p.Arg939Gln Single submitter ⚠
- p.Arg939Trp Single submitter ⚠
- p.Asn685Ser Single submitter ⚠
- p.Asp344Asn Single submitter ⚠
- p.Asp399His Single submitter ⚠
- p.Asp658Asn Single submitter ⚠
- p.Asp698Gly Single submitter ⚠
- p.Asp766Val Single submitter
- p.Asp883Asn Single submitter ⚠
- p.Asp964His Single submitter ⚠
- p.Gln141Pro Single submitter ⚠
- p.Gln287Arg Single submitter ⚠
- p.Gln28Pro Single submitter ⚠
- p.Gln53Glu Single submitter ⚠
- p.Gln584Lys Single submitter ⚠
- p.Gln674Glu Single submitter ⚠
- p.Gln764Arg Single submitter ⚠
- p.Glu134Ala Single submitter ⚠
- p.Glu147Lys Single submitter ⚠
- p.Glu180Lys Single submitter ⚠
- p.Glu231Lys Single submitter ⚠
- p.Glu741Gln Single submitter ⚠
- p.Glu921Lys Single submitter ⚠
- p.Glu954Gly Single submitter ⚠
- p.Gly143Ser Single submitter ⚠
- p.Gly16Ser Single submitter ⚠
- p.Gly181Val Single submitter ⚠
- p.Gly206Ala Single submitter ⚠
- p.Gly22Asp Single submitter ⚠
- p.Gly244Ala Single submitter ⚠
- p.Gly292Val Single submitter ⚠
- p.Gly29Asp Single submitter ⚠
- p.Gly2Cys Single submitter ⚠
- p.Gly2Ser Single submitter ⚠
- p.Gly322Arg Single submitter ⚠
- p.Gly350Asp Single submitter ⚠
- p.Gly425Asp Single submitter ⚠
- p.Gly489Ser Single submitter ⚠
- p.Gly540Ser Single submitter ⚠
- p.Gly593Arg Single submitter ⚠
- p.Gly941Ser Single submitter ⚠
- p.Gly965Glu Single submitter ⚠
- p.Gly985Arg Single submitter ⚠
- p.His116Asn Single submitter ⚠
- p.His175Gln Single submitter
- p.His190Arg Single submitter ⚠
- p.Ile459Met Single submitter ⚠
- p.Ile569Val Single submitter ⚠
- p.Ile657Val Single submitter ⚠
- p.Ile812Val Single submitter ⚠
- p.Leu146Pro Single submitter ⚠
- p.Leu195Pro Single submitter ⚠
- p.Leu733Val Single submitter ⚠
- p.Leu745Pro Single submitter ⚠
- p.Lys501Arg Single submitter ⚠
- p.Lys722Arg Single submitter ⚠
- p.Lys752Arg Single submitter ⚠
- p.Met358Val Single submitter ⚠
- p.Met534Thr Single submitter ⚠
- p.Met763Thr Single submitter ⚠
- p.Met826Val Single submitter
- p.Phe224Val Single submitter ⚠
- p.Phe237Leu Single submitter ⚠
- p.Phe577Val Single submitter ⚠
- p.Phe819Tyr Single submitter ⚠
- p.Pro173Gln Single submitter ⚠
- p.Pro313Leu Single submitter ⚠
- p.Pro323Ser Single submitter ⚠
- p.Pro421Ser Single submitter ⚠
- p.Pro42His Single submitter ⚠
- p.Pro432Arg Single submitter GRIN2C-related disorder
- p.Pro52Ser Single submitter ⚠
- p.Pro579Leu Single submitter ⚠
- p.Pro671Leu Single submitter ⚠
- p.Pro677Ser Single submitter
- p.Pro7Leu Single submitter ⚠
- p.Pro882Leu Single submitter ⚠
- p.Pro938Ala Single submitter ⚠
- p.Pro953Arg Single submitter ⚠
- p.Pro953Gln Single submitter ⚠
- p.Pro955Ser Single submitter ⚠
- p.Pro962Leu Single submitter ⚠
- p.Pro978Gln Single submitter ⚠
- p.Ser229Leu Single submitter ⚠
- p.Ser346Phe Single submitter ⚠
- p.Ser418Gly Single submitter ⚠
- p.Ser54Asn Single submitter ⚠
- p.Ser865Cys Single submitter
- p.Ser875Arg Single submitter ⚠
- p.Ser875Thr Single submitter ⚠
- p.Ser912Phe Single submitter ⚠
- p.Thr131Asn Single submitter ⚠
- p.Thr262Ile Single submitter ⚠
- p.Thr404Met Single submitter ⚠
- p.Thr450Asn Single submitter ⚠
- p.Thr51Ile Single submitter ⚠
- p.Thr644Met Single submitter ⚠
- p.Thr682Met Single submitter ⚠
- p.Thr72Ala Single submitter ⚠
- p.Tyr582His Single submitter ⚠
- p.Tyr656Asn Single submitter ⚠
- p.Val144Ala Single submitter ⚠
- p.Val152Met Single submitter ⚠
- p.Val182Ala Single submitter
- p.Val182Gly Single submitter ⚠
- p.Val223Leu Single submitter ⚠
- p.Val223Met Single submitter ⚠
- p.Val324Ile Single submitter ⚠
- p.Val414Leu Single submitter ⚠
- p.Val571Ile Single submitter ⚠
- p.Val67Ile Single submitter ⚠
- p.Val69Ile Single submitter ⚠
- p.Val971Leu Single submitter ⚠
- c.2583+4G>C No assertion criteria GRIN2C-related disorder
- p.Tyr1198_Arg1199delinsTer No assertion criteria GRIN2C-related disorder