GRIN3A — 150 ClinVar variants

All ClinVar germline GRIN3A variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 134 flagged for review →

1 Benign · 7 Likely benign · 142 Uncertain significance

Full GRIN3A gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions

⚑ Evidence disagreements 134

Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.

Predictors lean, ClinVar uncertain 111

ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.

Predictors split 23

The independent predictors disagree with each other — read with care.

All GRIN3A variants

Benign 1

p.Asn1062Ser Multiple submitters

Likely benign 7

p.Phe1029Leu Multiple submitters
p.Ala117Thr Single submitter
p.Arg1024Gln Single submitter
p.Arg337Gln Single submitter
p.Arg353His Single submitter
p.Tyr873= Single submitter
p.Val457Ile Single submitter

Uncertain significance 142

p.Ala1096Ser Single submitter ⚠
p.Ala127Thr Single submitter ⚠
p.Ala22Val Single submitter ⚠
p.Ala299Ser Single submitter ⚠
p.Ala397Thr Single submitter ⚠
p.Ala438Thr Single submitter ⚠
p.Ala637Ser Single submitter ⚠
p.Ala64Ser Single submitter ⚠
p.Ala668Gly Single submitter ⚠
p.Arg1009Cys Single submitter ⚠
p.Arg1009His Single submitter ⚠
p.Arg1041Trp Single submitter ⚠
p.Arg1052Lys Single submitter ⚠
p.Arg1053Ile Single submitter ⚠
p.Arg1059Gln Single submitter ⚠
p.Arg1072Gln Single submitter ⚠
p.Arg336Gln Single submitter ⚠
p.Arg337Leu Single submitter ⚠
p.Arg435Ser Single submitter
p.Arg49Ser Single submitter ⚠
p.Arg529Gly Single submitter ⚠
p.Arg63Leu Single submitter ⚠
p.Arg660Gln Single submitter ⚠
p.Arg67Pro Single submitter ⚠
p.Arg793Ser Single submitter ⚠
p.Arg999His Single submitter ⚠
p.Asn1023Ile Single submitter ⚠
p.Asn244Tyr Single submitter ⚠
p.Asn260Lys Single submitter ⚠
p.Asn285Lys Single submitter ⚠
p.Asn300Ser Single submitter ⚠
p.Asn462Asp Single submitter ⚠
p.Asn565Ser Single submitter ⚠
p.Asn709Asp Single submitter ⚠
p.Asn721Ser Single submitter ⚠
p.Asp1022Asn Single submitter ⚠
p.Asp160Asn Single submitter ⚠
p.Asp278Asn Single submitter ⚠
p.Asp306Ala Single submitter ⚠
p.Asp391Glu Single submitter ⚠
p.Asp533Asn Single submitter ⚠
p.Asp582Tyr Single submitter ⚠
p.Asp619Asn Single submitter ⚠
p.Asp804Val Single submitter
p.Asp856Val Single submitter ⚠
p.Asp858Asn Single submitter ⚠
p.Cys185Tyr Single submitter ⚠
p.Gln1010Lys Single submitter ⚠
p.Gln1085Leu Single submitter ⚠
p.Gln1091Glu Single submitter ⚠
p.Gln201Arg Single submitter ⚠
p.Gln925His Single submitter ⚠
p.Glu1033Lys Single submitter ⚠
p.Glu1083Ter Single submitter
p.Glu351Lys Single submitter ⚠
p.Glu815Gly Single submitter ⚠
p.Glu82Asp Single submitter ⚠
p.Glu830Lys Single submitter ⚠
p.Glu889Lys Single submitter ⚠
p.Gly1034Arg Single submitter ⚠
p.Gly1034Val Single submitter ⚠
p.Gly1063Ala Single submitter ⚠
p.Gly114Ala Single submitter ⚠
p.Gly204Asp Single submitter ⚠
p.Gly346Val Single submitter ⚠
p.Gly453Asp Single submitter ⚠
p.Gly453Val Single submitter ⚠
p.His226Arg Single submitter ⚠
p.His387Gln Single submitter ⚠
p.His506Asn Single submitter ⚠
p.His674Tyr Single submitter ⚠
p.His786Tyr Single submitter ⚠
p.Ile218Val Single submitter ⚠
p.Ile295Val Single submitter ⚠
p.Ile413Phe Single submitter ⚠
p.Ile495Met Single submitter ⚠
p.Ile521Ser Single submitter ⚠
p.Ile634Val Single submitter ⚠
p.Ile855Thr Single submitter ⚠
p.Ile875Val Single submitter ⚠
p.Ile946Leu Single submitter ⚠
p.Leu236Arg Single submitter ⚠
p.Leu23Pro Single submitter ⚠
p.Leu41Ile Single submitter ⚠
p.Leu597His Single submitter ⚠
p.Leu597Phe Single submitter ⚠
p.Leu727Phe Single submitter ⚠
p.Leu727Val Single submitter ⚠
p.Leu848Val Single submitter
p.Leu849Gln Single submitter ⚠
p.Lys1084Glu Single submitter ⚠
p.Met206Thr Single submitter ⚠
p.Met327Thr Single submitter ⚠
p.Met405Arg Single submitter ⚠
p.Met473Ile Single submitter ⚠
p.Met477Val Single submitter ⚠
p.Met547Val Single submitter ⚠
p.Met670Ile Single submitter ⚠
p.Phe558Ser Single submitter ⚠
p.Phe701Leu Single submitter ⚠
p.Phe810Leu Single submitter ⚠
p.Pro107Arg Single submitter ⚠
p.Pro107Leu Single submitter ⚠
p.Pro165Thr Single submitter ⚠
p.Pro177His Single submitter ⚠
p.Pro20Ser Single submitter ⚠
p.Pro235Thr Single submitter ⚠
p.Pro349Leu Single submitter ⚠
p.Pro497Ala Single submitter ⚠
p.Pro546Ala Single submitter ⚠
p.Pro546His Single submitter ⚠
p.Pro700Ser Single submitter ⚠
p.Ser303Pro Single submitter ⚠
p.Ser359Phe Single submitter ⚠
p.Ser809Gly Single submitter ⚠
p.Ser92Leu Single submitter ⚠
p.Ser986Pro Single submitter ⚠
p.Thr1101Met Single submitter ⚠
p.Thr441Ala Single submitter ⚠
p.Thr548Ile Single submitter
p.Thr60Ser Single submitter ⚠
p.Thr731Lys Single submitter ⚠
p.Thr761Met Single submitter ⚠
p.Trp496Arg Single submitter ⚠
p.Trp671Gly Single submitter ⚠
p.Trp697Cys Single submitter ⚠
p.Tyr388Asn Single submitter ⚠
p.Tyr493Cys Single submitter ⚠
p.Tyr493Phe Single submitter ⚠
p.Tyr577Cys Single submitter ⚠
p.Tyr956His Single submitter ⚠
p.Val1013Ile Single submitter ⚠
p.Val1070Ile Single submitter ⚠
p.Val1097Met Single submitter ⚠
p.Val138Leu Single submitter ⚠
p.Val400Ala Single submitter
p.Val400Ile Single submitter ⚠
p.Val641Leu Single submitter
p.Val767Ala Single submitter ⚠
p.Val829Ala Single submitter
p.Val911Leu Single submitter ⚠
p.Ser147Thr No assertion criteria myoepithelial tumor ⚠