GRIN3B — 266 ClinVar variants

All ClinVar germline GRIN3B variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 239 flagged for review →

1 Conflicting · 7 Benign · 10 Likely benign · 248 Uncertain significance

Full GRIN3B gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions

⚑ Evidence disagreements 239

Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.

Predictors agree, ClinVar conflicts 1

ClinVar submitters conflict, but the independent predictors unanimously agree — a QC review flag, not a reclassification.

GRIN3B p.Gln327Pro Conflicting Single submitter

Predictors lean, ClinVar uncertain 173

ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification. · showing the 150 best-reviewed of 173

Predictors split 65

The independent predictors disagree with each other — read with care.

All GRIN3B variants

Conflicting classifications of pathogenicity 1

p.Gln327Pro Single submitter ⚠

Benign 7

c.-17A>G Multiple submitters
p.Ala403= Multiple submitters
p.Glu852Lys Multiple submitters
p.His117Tyr Multiple submitters
p.Pro1039Arg Multiple submitters
p.Thr562= Multiple submitters
p.Thr577Met Multiple submitters

Likely benign 10

p.Ala971= Single submitter
p.Arg208Gln Single submitter
p.Arg216Gln Single submitter
p.Arg216Trp Single submitter ⚠
p.Arg989His Single submitter
p.Asp457= Single submitter
p.Gly449Ser Single submitter
p.Pro737His Single submitter ⚠
p.Pro80= Single submitter
p.Ser901= Single submitter

Uncertain significance 248

p.Ala1025Gly Single submitter ⚠
p.Ala1027Val Single submitter ⚠
p.Ala1028Thr Single submitter ⚠
p.Ala12Glu Single submitter ⚠
p.Ala141Val Single submitter ⚠
p.Ala164Val Single submitter ⚠
p.Ala223Val Single submitter ⚠
p.Ala224Gly Single submitter ⚠
p.Ala224Val Single submitter ⚠
p.Ala292Thr Single submitter ⚠
p.Ala307Val Single submitter ⚠
p.Ala319Val Single submitter ⚠
p.Ala380Thr Single submitter ⚠
p.Ala380Val Single submitter ⚠
p.Ala403Val Single submitter ⚠
p.Ala461Thr Single submitter ⚠
p.Ala462Val Single submitter ⚠
p.Ala507Thr Single submitter ⚠
p.Ala528Val Single submitter
p.Ala55Val Single submitter ⚠
p.Ala568Thr Single submitter ⚠
p.Ala583Glu Single submitter ⚠
p.Ala583Val Single submitter ⚠
p.Ala589Val Single submitter
p.Ala625Thr Single submitter ⚠
p.Ala702Asp Single submitter ⚠
p.Ala722Pro Single submitter ⚠
p.Ala722Val Single submitter ⚠
p.Ala741Val Single submitter
p.Ala769Thr Single submitter ⚠
p.Ala85Thr Single submitter ⚠
p.Ala882Ser Single submitter ⚠
p.Ala917Thr Single submitter ⚠
p.Ala924Thr Single submitter ⚠
p.Ala952Gly Single submitter ⚠
p.Ala972Thr Single submitter ⚠
p.Arg1003Gln Single submitter ⚠
p.Arg1003Trp Single submitter ⚠
p.Arg1016His Single submitter ⚠
p.Arg1016Pro Single submitter ⚠
p.Arg1021His Single submitter ⚠
p.Arg110Leu Single submitter ⚠
p.Arg132Leu Single submitter ⚠
p.Arg194Trp Single submitter ⚠
p.Arg197Trp Single submitter ⚠
p.Arg207Trp Single submitter ⚠
p.Arg208Gly Single submitter ⚠
p.Arg208Trp Single submitter ⚠
p.Arg244Cys Single submitter ⚠
p.Arg302Gln Single submitter ⚠
p.Arg336Cys Single submitter ⚠
p.Arg340Gln Single submitter ⚠
p.Arg340Trp Single submitter ⚠
p.Arg366Trp Single submitter ⚠
p.Arg374Cys Single submitter ⚠
p.Arg374His Single submitter ⚠
p.Arg375Trp Single submitter ⚠
p.Arg378Gln Single submitter ⚠
p.Arg378Trp Single submitter ⚠
p.Arg390Trp Single submitter ⚠
p.Arg431Cys Single submitter ⚠
p.Arg470His Single submitter ⚠
p.Arg486Gln Single submitter ⚠
p.Arg509Gln Single submitter ⚠
p.Arg50Cys Single submitter ⚠
p.Arg512Cys Single submitter ⚠
p.Arg524Gln Single submitter ⚠
p.Arg538His Single submitter ⚠
p.Arg558Trp Single submitter
p.Arg560Gln Single submitter ⚠
p.Arg560Trp Single submitter ⚠
p.Arg59Gln Single submitter ⚠
p.Arg606Cys Single submitter ⚠
p.Arg606His Single submitter ⚠
p.Arg606Leu Single submitter ⚠
p.Arg610Cys Single submitter ⚠
p.Arg630His Single submitter ⚠
p.Arg643His Single submitter ⚠
p.Arg719Cys Single submitter ⚠
p.Arg82His Single submitter ⚠
p.Arg857Gly Single submitter ⚠
p.Arg89Gly Single submitter ⚠
p.Arg923Gly Single submitter ⚠
p.Arg923Trp Single submitter ⚠
p.Arg926Gln Single submitter ⚠
p.Arg926Trp Single submitter ⚠
p.Arg968His Single submitter ⚠
p.Arg998Cys Single submitter ⚠
p.Asn69Lys Single submitter ⚠
p.Asp173Asn Single submitter ⚠
p.Asp325Gly Single submitter ⚠
p.Asp391Ala Single submitter ⚠
p.Asp391Gly Single submitter ⚠
p.Asp452Asn Single submitter ⚠
p.Asp682Asn Single submitter ⚠
p.Asp735Glu Single submitter ⚠
p.Asp805Gly Single submitter
p.Cys27Ser Single submitter ⚠
p.Cys445Gly Single submitter ⚠
p.Gln298Arg Single submitter ⚠
p.Gln540Glu Single submitter ⚠
p.Gln912Glu Single submitter ⚠
p.Glu172Gln Single submitter ⚠
p.Glu250Gln Single submitter ⚠
p.Glu283Lys Single submitter ⚠
p.Glu435Lys Single submitter ⚠
p.Glu496Lys Single submitter ⚠
p.Glu789Lys Single submitter ⚠
p.Glu886Asp Single submitter ⚠
p.Glu886Lys Single submitter ⚠
p.Glu897Gln Single submitter ⚠
p.Glu919Asp Single submitter ⚠
p.Glu947Ala Single submitter ⚠
p.Gly1040Ala Single submitter ⚠
p.Gly1040Glu Single submitter ⚠
p.Gly21Arg Single submitter ⚠
p.Gly227Glu Single submitter ⚠
p.Gly22Ser Single submitter ⚠
p.Gly239Ser Single submitter ⚠
p.Gly255Ser Single submitter ⚠
p.Gly305Asp Single submitter ⚠
p.Gly324Arg Single submitter ⚠
p.Gly330Arg Single submitter ⚠
p.Gly392Ser Single submitter ⚠
p.Gly501Asp Single submitter
p.Gly503Ser Single submitter ⚠
p.Gly506Asp Single submitter ⚠
p.Gly511Ser Single submitter ⚠
p.Gly567Arg Single submitter ⚠
p.Gly670Arg Single submitter ⚠
p.Gly695Arg Single submitter ⚠
p.Gly728Ser Single submitter ⚠
p.Gly776Arg Single submitter ⚠
p.Gly798Asp Single submitter ⚠
p.Gly851Arg Single submitter ⚠
p.Gly890Glu Single submitter ⚠
p.Gly920Asp Single submitter ⚠
p.Gly920Cys Single submitter ⚠
p.His117Leu Single submitter ⚠
p.His169Gln Single submitter ⚠
p.His425Tyr Single submitter ⚠
p.His526Tyr Single submitter ⚠
p.His686Gln Single submitter ⚠
p.His874Tyr Single submitter ⚠
p.Ile293Val Single submitter ⚠
p.Ile481Val Single submitter ⚠
p.Ile566Met Single submitter ⚠
p.Ile706Val Single submitter ⚠
p.Ile775Thr Single submitter ⚠
p.Leu114Pro Single submitter ⚠
p.Leu139Ile Single submitter ⚠
p.Leu147Val Single submitter ⚠
p.Leu159Pro Single submitter ⚠
p.Leu289Arg Single submitter ⚠
p.Leu30Val Single submitter ⚠
p.Leu573Pro Single submitter ⚠
p.Leu592Phe Single submitter
p.Leu62Pro Single submitter ⚠
p.Leu70Val Single submitter ⚠
p.Leu732Arg Single submitter ⚠
p.Leu739Phe Single submitter ⚠
p.Leu748Val Single submitter ⚠
p.Leu762Arg Single submitter ⚠
p.Leu803His Single submitter ⚠
p.Leu87Met Single submitter ⚠
p.Lys815Asn Single submitter ⚠
p.Lys865Thr Single submitter ⚠
p.Met646Ile Single submitter ⚠
p.Met646Val Single submitter ⚠
p.Phe3Cys Single submitter ⚠
p.Phe495Leu Single submitter ⚠
p.Phe569Leu Single submitter ⚠
p.Phe710Leu Single submitter ⚠
p.Pro144Ala Single submitter ⚠
p.Pro221Leu Single submitter ⚠
p.Pro231Leu Single submitter ⚠
p.Pro265Leu Single submitter ⚠
p.Pro276Ser Single submitter ⚠
p.Pro287His Single submitter ⚠
p.Pro288Leu Single submitter ⚠
p.Pro312Leu Single submitter ⚠
p.Pro328Leu Single submitter ⚠
p.Pro381Leu Single submitter ⚠
p.Pro398Leu Single submitter ⚠
p.Pro406Leu Single submitter ⚠
p.Pro448Arg Single submitter ⚠
p.Pro44Ser Single submitter ⚠
p.Pro565Thr Single submitter ⚠
p.Pro600His Single submitter
p.Pro600Thr Single submitter
p.Pro67Ala Single submitter ⚠
p.Pro688Leu Single submitter ⚠
p.Pro726Leu Single submitter ⚠
p.Pro736Ala Single submitter ⚠
p.Pro736Thr Single submitter ⚠
p.Pro778Leu Single submitter ⚠
p.Pro778Thr Single submitter
p.Pro79Leu Single submitter ⚠
p.Pro812Ser Single submitter ⚠
p.Pro888Ser Single submitter ⚠
p.Pro918Leu Single submitter ⚠
p.Pro940Ser Single submitter ⚠
p.Pro978Leu Single submitter ⚠
p.Ser346Thr Single submitter ⚠
p.Ser467Leu Single submitter ⚠
p.Ser533Gly Single submitter ⚠
p.Ser546Gly Single submitter ⚠
p.Ser576Tyr Single submitter ⚠
p.Ser618Leu Single submitter ⚠
p.Ser659Asn Single submitter
p.Ser700Asn Single submitter ⚠
p.Ser71Ile Single submitter ⚠
p.Ser734Arg Single submitter ⚠
p.Ser788Cys Single submitter ⚠
p.Ser796Phe Single submitter ⚠
p.Ser797Cys Single submitter ⚠
p.Ser849Leu Single submitter ⚠
p.Ser867Gly Single submitter ⚠
p.Thr123Ala Single submitter ⚠
p.Thr345Met Single submitter ⚠
p.Thr455Ile Single submitter ⚠
p.Thr604Met Single submitter neurodevelopmental disorder ⚠
p.Thr612Ile Single submitter ⚠
p.Thr641Met Single submitter ⚠
p.Thr661Ala Single submitter ⚠
p.Thr725Ala Single submitter ⚠
p.Trp171Cys Single submitter ⚠
p.Trp371Cys Single submitter ⚠
p.Trp513Arg Single submitter ⚠
p.Trp597Gly Single submitter
p.Tyr479Cys Single submitter ⚠
p.Tyr616Cys Single submitter ⚠
p.Tyr705Cys Single submitter neurodevelopmental disorder ⚠
p.Tyr808Phe Single submitter ⚠
p.Val127Met Single submitter ⚠
p.Val174Leu Single submitter ⚠
p.Val188Ala Single submitter ⚠
p.Val252Ile Single submitter ⚠
p.Val297Met Single submitter ⚠
p.Val354Met Single submitter ⚠
p.Val517Ile Single submitter ⚠
p.Val632Met Single submitter ⚠
p.Val697Leu Single submitter ⚠
p.Val729Ala Single submitter ⚠
p.Val817Ile Single submitter ⚠
p.Val905Glu Single submitter ⚠
p.Val934Leu Single submitter ⚠
p.Val961Ile Single submitter ⚠