Sugi Variant

Sugi Variant/GRIP1

GRIP1 — 811 ClinVar variants

All ClinVar germline GRIP1 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 225 flagged for review →

13 Pathogenic · 1 Pathogenic/Likely pathogenic · 17 Likely pathogenic · 23 Conflicting · 18 Benign · 10 Benign/Likely benign · 460 Likely benign · 269 Uncertain significance

Full GRIP1 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions

⚑ Evidence disagreements 225

Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.

Predictors agree, ClinVar conflicts 8

ClinVar submitters conflict, but the independent predictors unanimously agree — a QC review flag, not a reclassification.

Predictors lean, ClinVar uncertain 153

ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification. · showing the 150 best-reviewed of 153

Predictors split 64

The independent predictors disagree with each other — read with care.

All GRIP1 variants

Pathogenic 13

Pathogenic/Likely pathogenic 1

  • p.Cys10Ter Multiple submitters Fraser syndrome 3

Likely pathogenic 17

Conflicting classifications of pathogenicity 23

Benign 18

Benign/Likely benign 10

Likely benign 460

Showing the top 300 by review status; the full set is in the sitemap.

Uncertain significance 269