Sugi Variant

Sugi Variant/GRK1

GRK1 — 217 ClinVar variants

All ClinVar germline GRK1 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 93 flagged for review →

4 Pathogenic · 3 Pathogenic/Likely pathogenic · 20 Likely pathogenic · 8 Conflicting · 8 Benign · 78 Likely benign · 96 Uncertain significance

Full GRK1 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions

⚑ Evidence disagreements 93

Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.

Predictors agree, ClinVar conflicts 4

ClinVar submitters conflict, but the independent predictors unanimously agree — a QC review flag, not a reclassification.

Predictors lean, ClinVar uncertain 57

ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.

Predictors split 32

The independent predictors disagree with each other — read with care.

All GRK1 variants

Pathogenic 4

Pathogenic/Likely pathogenic 3

Likely pathogenic 20

Conflicting classifications of pathogenicity 8

Benign 8

Likely benign 78

Uncertain significance 96