GRK3 — 6 ClinVar variants
All ClinVar germline GRK3 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 4 flagged for review →
1 Benign · 5 Uncertain significance
Full GRK3 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 4
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 2
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
Predictors split 2
The independent predictors disagree with each other — read with care.
All GRK3 variants
Benign 1
- p.Arg311= Multiple submitters
Uncertain significance 5
- p.Arg295Trp Single submitter
- p.His307Tyr Single submitter ⚠
- p.Lys57Arg Single submitter ⚠
- p.Thr54Ser Single submitter ⚠
- p.Tyr112Cys Single submitter ⚠