GRK4 — 96 ClinVar variants

All ClinVar germline GRK4 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 79 flagged for review →

2 Benign · 5 Likely benign · 89 Uncertain significance

Full GRK4 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions

⚑ Evidence disagreements 79

Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.

Predictors lean, ClinVar uncertain 50

ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.

Predictors split 29

The independent predictors disagree with each other — read with care.

All GRK4 variants

Benign 2

p.Gln173Ter Multiple submitters
p.Gly283= Single submitter

Likely benign 5

p.Arg108= Single submitter
p.Arg323His Single submitter
p.Arg342Thr Single submitter
p.Glu532Lys Single submitter
p.Val350= Single submitter

Uncertain significance 89

p.Ala203Thr Single submitter ⚠
p.Ala259Gly Single submitter ⚠
p.Ala334Gly Single submitter
p.Ala86Thr Single submitter ⚠
p.Arg108Lys Single submitter ⚠
p.Arg207Gln Single submitter ⚠
p.Arg226Lys Single submitter ⚠
p.Arg237Ile Single submitter ⚠
p.Arg26His Single submitter
p.Arg327Gln Single submitter ⚠
p.Arg344Gln Single submitter ⚠
p.Arg432Gln Single submitter ⚠
p.Arg432Trp Single submitter ⚠
p.Arg502Trp Single submitter ⚠
p.Arg65Cys Single submitter ⚠
p.Asn317Thr Single submitter ⚠
p.Asn9Ser Single submitter ⚠
p.Asp285Gly Single submitter ⚠
p.Asp52Val Single submitter ⚠
p.Cys202Tyr Single submitter ⚠
p.Cys204Gly Single submitter ⚠
p.Cys215Phe Single submitter
p.Cys298Tyr Single submitter ⚠
p.Cys421Tyr Single submitter ⚠
p.Cys475Ser Single submitter
p.Gln219Lys Single submitter ⚠
p.Gln243Arg Single submitter ⚠
p.Gln513Pro Single submitter ⚠
p.Glu136Asp Single submitter ⚠
p.Glu255Asp Single submitter
p.Glu301Lys Single submitter ⚠
p.Glu356Lys Single submitter ⚠
p.Glu396Asp Single submitter ⚠
p.Glu407Asp Single submitter ⚠
p.Glu407Lys Single submitter ⚠
p.Glu411Asp Single submitter ⚠
p.Glu438Ala Single submitter ⚠
p.Glu518Asp Single submitter ⚠
p.Glu572Asp Single submitter ⚠
p.Gly19Val Single submitter ⚠
p.Gly270Glu Single submitter ⚠
p.Gly283Ser Single submitter ⚠
p.Gly351Asp Single submitter ⚠
p.Gly434Ala Single submitter
p.Gly434Arg Single submitter ⚠
p.Gly489Arg Single submitter ⚠
p.His151Arg Single submitter ⚠
p.His275Tyr Single submitter ⚠
p.Ile380Val Single submitter ⚠
p.Ile481Val Single submitter ⚠
p.Ile81Val Single submitter ⚠
p.Leu320Arg Single submitter ⚠
p.Leu331Phe Single submitter ⚠
p.Leu3Phe Single submitter ⚠
p.Leu3Pro Single submitter
p.Leu479Pro Single submitter ⚠
p.Leu492Arg Single submitter ⚠
p.Leu56Pro Single submitter ⚠
p.Leu84Ser Single submitter ⚠
p.Lys217Glu Single submitter
p.Lys392Glu Single submitter ⚠
p.Lys527Ile Single submitter ⚠
p.Met461Thr Single submitter ⚠
p.Phe284Leu Single submitter ⚠
p.Phe499Leu Single submitter ⚠
p.Pro138Ser Single submitter ⚠
p.Pro158Ala Single submitter ⚠
p.Pro181Ala Single submitter ⚠
p.Pro338Ser Single submitter ⚠
p.Pro355Thr Single submitter ⚠
p.Pro37Thr Single submitter ⚠
p.Pro465His Single submitter
p.Pro511Leu Single submitter ⚠
p.Pro568Ser Single submitter ⚠
p.Ser169Cys Single submitter ⚠
p.Ser27Asn Single submitter ⚠
p.Ser40Arg Single submitter ⚠
p.Ser485Leu Single submitter ⚠
p.Ser547Phe Single submitter ⚠
p.Thr183Arg Single submitter ⚠
p.Trp369Cys Single submitter ⚠
p.Tyr167His Single submitter ⚠
p.Tyr252Phe Single submitter ⚠
p.Tyr363Cys Single submitter ⚠
p.Tyr409His Single submitter ⚠
p.Val182Ile Single submitter ⚠
p.Val343Leu Single submitter ⚠
p.Val443Met Single submitter
p.Val508Ile Single submitter ⚠