GRK5 — 85 ClinVar variants
All ClinVar germline GRK5 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 75 flagged for review →
7 Benign · 4 Likely benign · 74 Uncertain significance
Full GRK5 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 75
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 41
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- GRK5 p.Arg169His Uncertain significance Single submitter
- GRK5 p.Arg206Trp Uncertain significance Single submitter
- GRK5 p.Arg345Trp Uncertain significance Single submitter
- GRK5 p.Arg386Cys Uncertain significance Single submitter
- GRK5 p.Arg400Trp Uncertain significance Single submitter
- GRK5 p.Arg553Lys Uncertain significance Single submitter
- GRK5 p.Asn525Lys Uncertain significance Single submitter
- GRK5 p.Asp52Glu Uncertain significance Single submitter
- GRK5 p.Cys201Tyr Uncertain significance Single submitter
- GRK5 p.Gln179Pro Uncertain significance Single submitter
- GRK5 p.Glu151Gln Uncertain significance Single submitter
- GRK5 p.Glu239Gly Uncertain significance Single submitter
- GRK5 p.Glu284Ala Uncertain significance Single submitter
- GRK5 p.Glu286Lys Uncertain significance Single submitter
- GRK5 p.Glu294Gln Uncertain significance Single submitter
- GRK5 p.Glu395Gly Uncertain significance Single submitter
- GRK5 p.Glu414Lys Uncertain significance Single submitter
- GRK5 p.Gly102Arg Uncertain significance Single submitter
- GRK5 p.Gly196Ala Uncertain significance Single submitter
- GRK5 p.Gly19Ser Uncertain significance Single submitter
- GRK5 p.Gly20Arg Uncertain significance Single submitter
- GRK5 p.Gly387Ser Uncertain significance Single submitter
- GRK5 p.Gly488Asp Uncertain significance Single submitter
- GRK5 p.Gly588Arg Uncertain significance Single submitter
- GRK5 p.His445Gln Uncertain significance Single submitter
- GRK5 p.Ile39Val Uncertain significance Single submitter
- GRK5 p.Ile577Val Uncertain significance Single submitter
- GRK5 p.Leu34Arg Uncertain significance Single submitter
- GRK5 p.Lys29Thr Uncertain significance Single submitter
- GRK5 p.Lys487Glu Uncertain significance Single submitter
- GRK5 p.Met460Leu Uncertain significance Single submitter
- GRK5 p.Phe186Leu Uncertain significance Single submitter
- GRK5 p.Phe498Tyr Uncertain significance Single submitter
- GRK5 p.Pro115Ser Uncertain significance Single submitter
- GRK5 p.Thr107Ala Uncertain significance Single submitter
- GRK5 p.Thr348Ala Uncertain significance Single submitter
- GRK5 p.Tyr251Cys Uncertain significance Single submitter
- GRK5 p.Val116Phe Uncertain significance Single submitter
- GRK5 p.Val126Ile Uncertain significance Single submitter
- GRK5 p.Val205Phe Uncertain significance Single submitter
- GRK5 p.Val349Phe Uncertain significance Single submitter
Predictors split 34
The independent predictors disagree with each other — read with care.
- GRK5 p.Ala119Val Benign Multiple submitters
- GRK5 p.Ala471Thr Uncertain significance Single submitter
- GRK5 p.Arg216Cys Uncertain significance Single submitter
- GRK5 p.Arg343Cys Uncertain significance Single submitter
- GRK5 p.Arg361Ser Uncertain significance Single submitter
- GRK5 p.Arg399His Uncertain significance Single submitter
- GRK5 p.Arg400Gln Uncertain significance Single submitter
- GRK5 p.Arg46Gln Uncertain significance Single submitter
- GRK5 p.Arg557Gln Uncertain significance Single submitter
- GRK5 p.Arg74Gly Uncertain significance Single submitter
- GRK5 p.Asp44Gly Uncertain significance Single submitter
- GRK5 p.Asp497Asn Uncertain significance Single submitter
- GRK5 p.Asp52Val Uncertain significance Single submitter
- GRK5 p.Gln179His Uncertain significance Single submitter
- GRK5 p.Gln82His Uncertain significance Single submitter
- GRK5 p.Glu151Lys Uncertain significance Single submitter
- GRK5 p.Glu284Lys Uncertain significance Single submitter
- GRK5 p.Glu457Lys Uncertain significance Single submitter
- GRK5 p.Gly339Glu Uncertain significance Single submitter
- GRK5 p.Gly344Ser Uncertain significance Single submitter
- GRK5 p.Gly363Cys Uncertain significance Single submitter
- GRK5 p.Gly370Ser Uncertain significance Single submitter
- GRK5 p.Gly387Cys Uncertain significance Single submitter
- GRK5 p.Gly531Asp Uncertain significance Single submitter
- GRK5 p.Ile49Leu Uncertain significance Single submitter
- GRK5 p.Leu110Phe Uncertain significance Single submitter
- GRK5 p.Phe412Leu Uncertain significance Single submitter
- GRK5 p.Pro137Leu Uncertain significance Single submitter
- GRK5 p.Ser508Phe Uncertain significance Single submitter
- GRK5 p.Ser572Cys Uncertain significance Single submitter
- GRK5 p.Thr425Met Benign Single submitter
- GRK5 p.Val121Ala Uncertain significance Single submitter
- GRK5 p.Val308Ile Uncertain significance Single submitter
-
GRK5 p.Glu285Asp
Uncertain significance
No assertion criteria
GRK5-related disorder
All GRK5 variants
Benign 7
- c.440+9C>T Multiple submitters
- p.Ala119Val Multiple submitters ⚠
- p.Leu141Ile Multiple submitters
- p.Phe448Leu Multiple submitters
- c.52+42775A>G Single submitter
- p.Ser413= Single submitter
- p.Thr425Met Single submitter ⚠
Likely benign 4
- c.440+10G>A Multiple submitters
- p.Asn513= Single submitter
- p.Val466Ile Single submitter
- p.Thr182= No assertion criteria GRK5-related disorder
Uncertain significance 74
- p.Ala471Thr Single submitter ⚠
- p.Arg169His Single submitter ⚠
- p.Arg206Trp Single submitter ⚠
- p.Arg216Cys Single submitter ⚠
- p.Arg343Cys Single submitter ⚠
- p.Arg345Trp Single submitter ⚠
- p.Arg361Ser Single submitter ⚠
- p.Arg386Cys Single submitter ⚠
- p.Arg399His Single submitter ⚠
- p.Arg400Gln Single submitter ⚠
- p.Arg400Trp Single submitter ⚠
- p.Arg46Gln Single submitter ⚠
- p.Arg553Lys Single submitter ⚠
- p.Arg557Gln Single submitter ⚠
- p.Arg74Gly Single submitter ⚠
- p.Asn525Lys Single submitter ⚠
- p.Asp44Gly Single submitter ⚠
- p.Asp497Asn Single submitter ⚠
- p.Asp52Glu Single submitter ⚠
- p.Asp52Val Single submitter ⚠
- p.Cys201Tyr Single submitter ⚠
- p.Gln179His Single submitter ⚠
- p.Gln179Pro Single submitter ⚠
- p.Gln82His Single submitter ⚠
- p.Glu151Gln Single submitter ⚠
- p.Glu151Lys Single submitter ⚠
- p.Glu239Gly Single submitter ⚠
- p.Glu284Ala Single submitter ⚠
- p.Glu284Lys Single submitter ⚠
- p.Glu286Lys Single submitter ⚠
- p.Glu294Gln Single submitter ⚠
- p.Glu395Gly Single submitter ⚠
- p.Glu414Lys Single submitter ⚠
- p.Glu457Lys Single submitter ⚠
- p.Gly102Arg Single submitter ⚠
- p.Gly196Ala Single submitter ⚠
- p.Gly19Ser Single submitter ⚠
- p.Gly20Arg Single submitter ⚠
- p.Gly339Glu Single submitter ⚠
- p.Gly344Ser Single submitter ⚠
- p.Gly363Cys Single submitter ⚠
- p.Gly370Ser Single submitter ⚠
- p.Gly387Cys Single submitter ⚠
- p.Gly387Ser Single submitter ⚠
- p.Gly488Asp Single submitter ⚠
- p.Gly531Asp Single submitter ⚠
- p.Gly588Arg Single submitter ⚠
- p.His445Gln Single submitter ⚠
- p.Ile39Val Single submitter ⚠
- p.Ile49Leu Single submitter ⚠
- p.Ile577Val Single submitter ⚠
- p.Leu110Phe Single submitter ⚠
- p.Leu34Arg Single submitter ⚠
- p.Lys29Thr Single submitter ⚠
- p.Lys487Glu Single submitter ⚠
- p.Met460Leu Single submitter ⚠
- p.Phe186Leu Single submitter ⚠
- p.Phe412Leu Single submitter ⚠
- p.Phe498Tyr Single submitter ⚠
- p.Pro115Ser Single submitter ⚠
- p.Pro137Leu Single submitter ⚠
- p.Ser508Phe Single submitter ⚠
- p.Ser572Cys Single submitter ⚠
- p.Thr107Ala Single submitter ⚠
- p.Thr348Ala Single submitter ⚠
- p.Tyr251Cys Single submitter ⚠
- p.Val116Phe Single submitter ⚠
- p.Val11Phe Single submitter neurodevelopmental disorder
- p.Val121Ala Single submitter ⚠
- p.Val126Ile Single submitter ⚠
- p.Val205Phe Single submitter ⚠
- p.Val308Ile Single submitter ⚠
- p.Val349Phe Single submitter ⚠
- p.Glu285Asp No assertion criteria GRK5-related disorder ⚠