GRK6 — 60 ClinVar variants
All ClinVar germline GRK6 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 54 flagged for review →
4 Likely benign · 56 Uncertain significance
Full GRK6 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 54
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 42
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- GRK6 p.Ala258Val Uncertain significance Single submitter
- GRK6 p.Ala429Val Uncertain significance Single submitter
- GRK6 p.Arg123Gln Uncertain significance Single submitter
- GRK6 p.Arg123Leu Uncertain significance Single submitter
- GRK6 p.Arg123Trp Uncertain significance Single submitter
- GRK6 p.Arg169Cys Uncertain significance Single submitter
- GRK6 p.Arg23Cys Uncertain significance Single submitter
- GRK6 p.Arg304Gln Uncertain significance Single submitter
- GRK6 p.Arg306Cys Uncertain significance Single submitter
- GRK6 p.Arg411Cys Uncertain significance Single submitter
- GRK6 p.Arg435Cys Uncertain significance Single submitter
- GRK6 p.Arg51His Uncertain significance Single submitter
- GRK6 p.Arg68Gln Uncertain significance Single submitter
- GRK6 p.Arg79His Uncertain significance Single submitter
- GRK6 p.Asp163His Uncertain significance Single submitter
- GRK6 p.Asp321Gly Uncertain significance Single submitter
- GRK6 p.Asp427Glu Uncertain significance Single submitter
- GRK6 p.Asp85Glu Uncertain significance Single submitter
- GRK6 p.Gln496Arg Uncertain significance Single submitter
- GRK6 p.Gln512Arg Uncertain significance Single submitter
- GRK6 p.Glu151Asp Uncertain significance Single submitter
- GRK6 p.Glu151Gly Uncertain significance Single submitter
- GRK6 p.Glu151Lys Uncertain significance Single submitter
- GRK6 p.Glu430Lys Uncertain significance Single submitter
- GRK6 p.Glu490Val Uncertain significance Single submitter
- GRK6 p.His335Arg Uncertain significance Single submitter
- GRK6 p.Lys343Arg Uncertain significance Single submitter
- GRK6 p.Phe412Leu Uncertain significance Single submitter
- GRK6 p.Phe483Ser Uncertain significance Single submitter
- GRK6 p.Pro414Leu Uncertain significance Single submitter
- GRK6 p.Pro547Arg Uncertain significance Single submitter
- GRK6 p.Pro94Leu Uncertain significance Single submitter
- GRK6 p.Ser383Leu Uncertain significance Single submitter
- GRK6 p.Ser48Arg Uncertain significance Single submitter
- GRK6 p.Thr127Met Uncertain significance Single submitter
- GRK6 p.Thr146Asn Uncertain significance Single submitter
- GRK6 p.Thr146Ile Uncertain significance Single submitter
- GRK6 p.Thr485Met Uncertain significance Single submitter
- GRK6 p.Val200Gly Uncertain significance Single submitter
- GRK6 p.Val289Ile Uncertain significance Single submitter
- GRK6 p.Val533Leu Uncertain significance Single submitter
- GRK6 p.Val92Leu Uncertain significance Single submitter
Predictors split 12
The independent predictors disagree with each other — read with care.
- GRK6 p.Arg31Trp Uncertain significance Single submitter
- GRK6 p.Arg399Gln Uncertain significance Single submitter
- GRK6 p.Arg558His Uncertain significance Single submitter
- GRK6 p.Asn359Asp Uncertain significance Single submitter
- GRK6 p.Cys562Tyr Uncertain significance Single submitter
- GRK6 p.Cys80Arg Uncertain significance Single submitter
- GRK6 p.Glu43Lys Uncertain significance Single submitter
- GRK6 p.Glu519Lys Uncertain significance Single submitter
- GRK6 p.Ile275Val Uncertain significance Single submitter
- GRK6 p.Phe36Leu Uncertain significance Single submitter
- GRK6 p.Pro463Ser Uncertain significance Single submitter
- GRK6 p.Ser365Thr Uncertain significance Single submitter
All GRK6 variants
Likely benign 4
- p.Asp567Asn Single submitter
- p.Gln559= Single submitter
- p.Glu569Lys Single submitter
- p.Ser568= Single submitter
Uncertain significance 56
- c.*33G>A Single submitter
- p.Ala258Val Single submitter ⚠
- p.Ala429Val Single submitter ⚠
- p.Arg123Gln Single submitter ⚠
- p.Arg123Leu Single submitter ⚠
- p.Arg123Trp Single submitter ⚠
- p.Arg169Cys Single submitter ⚠
- p.Arg23Cys Single submitter ⚠
- p.Arg304Gln Single submitter ⚠
- p.Arg306Cys Single submitter ⚠
- p.Arg31Trp Single submitter ⚠
- p.Arg399Gln Single submitter ⚠
- p.Arg411Cys Single submitter ⚠
- p.Arg435Cys Single submitter ⚠
- p.Arg51His Single submitter ⚠
- p.Arg558His Single submitter ⚠
- p.Arg68Gln Single submitter ⚠
- p.Arg79His Single submitter ⚠
- p.Asn359Asp Single submitter ⚠
- p.Asp163His Single submitter ⚠
- p.Asp321Gly Single submitter ⚠
- p.Asp427Glu Single submitter ⚠
- p.Asp85Glu Single submitter ⚠
- p.Cys562Tyr Single submitter ⚠
- p.Cys80Arg Single submitter ⚠
- p.Gln496Arg Single submitter ⚠
- p.Gln512Arg Single submitter ⚠
- p.Glu151Asp Single submitter ⚠
- p.Glu151Gly Single submitter ⚠
- p.Glu151Lys Single submitter ⚠
- p.Glu430Lys Single submitter ⚠
- p.Glu43Lys Single submitter ⚠
- p.Glu490Val Single submitter ⚠
- p.Glu519Lys Single submitter ⚠
- p.His335Arg Single submitter ⚠
- p.Ile275Val Single submitter ⚠
- p.Lys343Arg Single submitter ⚠
- p.Phe36Leu Single submitter ⚠
- p.Phe412Leu Single submitter ⚠
- p.Phe483Ser Single submitter ⚠
- p.Pro414Leu Single submitter ⚠
- p.Pro463Ser Single submitter ⚠
- p.Pro547Arg Single submitter ⚠
- p.Pro573= Single submitter
- p.Pro94Leu Single submitter ⚠
- p.Ser365Thr Single submitter ⚠
- p.Ser383Leu Single submitter ⚠
- p.Ser48Arg Single submitter ⚠
- p.Thr127Met Single submitter ⚠
- p.Thr146Asn Single submitter ⚠
- p.Thr146Ile Single submitter ⚠
- p.Thr485Met Single submitter ⚠
- p.Val200Gly Single submitter ⚠
- p.Val289Ile Single submitter ⚠
- p.Val533Leu Single submitter ⚠
- p.Val92Leu Single submitter ⚠