GRK7 — 87 ClinVar variants
All ClinVar germline GRK7 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 85 flagged for review →
1 Likely benign · 86 Uncertain significance
Full GRK7 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 85
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 66
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- GRK7 p.Ala298Thr Uncertain significance Single submitter
- GRK7 p.Ala351Asp Uncertain significance Single submitter
- GRK7 p.Ala46Thr Uncertain significance Single submitter
- GRK7 p.Ala6Asp Uncertain significance Single submitter
- GRK7 p.Ala84Glu Uncertain significance Single submitter
- GRK7 p.Arg286His Uncertain significance Single submitter
- GRK7 p.Arg34Gln Uncertain significance Single submitter
- GRK7 p.Arg388Gln Uncertain significance Single submitter
- GRK7 p.Arg438His Uncertain significance Single submitter
- GRK7 p.Arg535Thr Uncertain significance Single submitter
- GRK7 p.Arg68Leu Uncertain significance Single submitter
- GRK7 p.Arg71Cys Uncertain significance Single submitter
- GRK7 p.Asp165Asn Uncertain significance Single submitter
- GRK7 p.Asp173Asn Uncertain significance Single submitter
- GRK7 p.Asp326Asn Uncertain significance Single submitter
- GRK7 p.Asp499Asn Uncertain significance Single submitter
- GRK7 p.Asp499Gly Uncertain significance Single submitter
- GRK7 p.Cys219Arg Uncertain significance Single submitter
- GRK7 p.Cys219Tyr Uncertain significance Single submitter
- GRK7 p.Gln128Glu Uncertain significance Single submitter
- GRK7 p.Gln405His Uncertain significance Single submitter
- GRK7 p.Glu182Gln Uncertain significance Single submitter
- GRK7 p.Glu47Lys Uncertain significance Single submitter
- GRK7 p.Gly120Arg Uncertain significance Single submitter
- GRK7 p.Gly232Asp Uncertain significance Single submitter
- GRK7 p.Gly548Asp Uncertain significance Single submitter
- GRK7 p.Gly548Val Uncertain significance Single submitter
- GRK7 p.Gly66Arg Uncertain significance Single submitter
- GRK7 p.His279Gln Uncertain significance Single submitter
- GRK7 p.Ile294Met Uncertain significance Single submitter
- GRK7 p.Leu237Phe Uncertain significance Single submitter
- GRK7 p.Leu551Phe Uncertain significance Single submitter
- GRK7 p.Lys404Arg Uncertain significance Single submitter
- GRK7 p.Lys433Asn Uncertain significance Single submitter
- GRK7 p.Lys433Glu Uncertain significance Single submitter
- GRK7 p.Met216Thr Uncertain significance Single submitter
- GRK7 p.Met235Leu Uncertain significance Single submitter
- GRK7 p.Met317Val Uncertain significance Single submitter
- GRK7 p.Met384Ile Uncertain significance Single submitter
- GRK7 p.Phe202Leu Uncertain significance Single submitter
- GRK7 p.Phe80Val Uncertain significance Single submitter
- GRK7 p.Pro185Ser Uncertain significance Single submitter
- GRK7 p.Pro319Ala Uncertain significance Single submitter
- GRK7 p.Pro319Thr Uncertain significance Single submitter
- GRK7 p.Pro470Leu Uncertain significance Single submitter
- GRK7 p.Ser115Asn Uncertain significance Single submitter
- GRK7 p.Ser247Thr Uncertain significance Single submitter
- GRK7 p.Ser291Arg Uncertain significance Single submitter
- GRK7 p.Ser53Cys Uncertain significance Single submitter
- GRK7 p.Thr192Ala Uncertain significance Single submitter
- GRK7 p.Thr285Met Uncertain significance Single submitter
- GRK7 p.Thr285Ser Uncertain significance Single submitter
- GRK7 p.Thr537Met Uncertain significance Single submitter
- GRK7 p.Trp178Arg Uncertain significance Single submitter
- GRK7 p.Trp93Arg Uncertain significance Single submitter
- GRK7 p.Tyr16Cys Uncertain significance Single submitter
- GRK7 p.Tyr256Cys Uncertain significance Single submitter
- GRK7 p.Tyr370Cys Uncertain significance Single submitter
- GRK7 p.Val246Ile Uncertain significance Single submitter
- GRK7 p.Val283Leu Uncertain significance Single submitter
- GRK7 p.Val283Met Uncertain significance Single submitter
- GRK7 p.Val339Met Uncertain significance Single submitter
- GRK7 p.Val398Ile Uncertain significance Single submitter
- GRK7 p.Val398Leu Uncertain significance Single submitter
- GRK7 p.Val549Ala Uncertain significance Single submitter
- GRK7 p.Val90Met Uncertain significance Single submitter
Predictors split 19
The independent predictors disagree with each other — read with care.
- GRK7 p.Ala236Gly Uncertain significance Single submitter
- GRK7 p.Arg20Trp Uncertain significance Single submitter
- GRK7 p.Arg32Trp Uncertain significance Single submitter
- GRK7 p.Arg493Trp Uncertain significance Single submitter
- GRK7 p.Asn282Thr Uncertain significance Single submitter
- GRK7 p.Asn354Lys Uncertain significance Single submitter
- GRK7 p.Asp173Val Uncertain significance Single submitter
- GRK7 p.Cys134Tyr Uncertain significance Single submitter
- GRK7 p.Gln349His Uncertain significance Single submitter
- GRK7 p.Gln409Pro Uncertain significance Single submitter
- GRK7 p.Glu411Lys Uncertain significance Single submitter
- GRK7 p.Glu61Lys Uncertain significance Single submitter
- GRK7 p.Lys221Asn Uncertain significance Single submitter
- GRK7 p.Lys245Glu Uncertain significance Single submitter
- GRK7 p.Met235Ile Uncertain significance Single submitter
- GRK7 p.Pro435Thr Uncertain significance Single submitter
- GRK7 p.Pro64Ser Uncertain significance Single submitter
- GRK7 p.Val130Met Likely benign Single submitter
- GRK7 p.Val398Phe Uncertain significance Single submitter
All GRK7 variants
Likely benign 1
- p.Val130Met Single submitter ⚠
Uncertain significance 86
- p.Ala236Gly Single submitter ⚠
- p.Ala298Thr Single submitter ⚠
- p.Ala351Asp Single submitter ⚠
- p.Ala46Thr Single submitter ⚠
- p.Ala6Asp Single submitter ⚠
- p.Ala84Glu Single submitter ⚠
- p.Arg20Trp Single submitter ⚠
- p.Arg286His Single submitter ⚠
- p.Arg292Gln Single submitter
- p.Arg32Trp Single submitter ⚠
- p.Arg34Gln Single submitter ⚠
- p.Arg388Gln Single submitter ⚠
- p.Arg438His Single submitter ⚠
- p.Arg493Trp Single submitter ⚠
- p.Arg535Thr Single submitter ⚠
- p.Arg68Leu Single submitter ⚠
- p.Arg71Cys Single submitter ⚠
- p.Asn282Thr Single submitter ⚠
- p.Asn354Lys Single submitter ⚠
- p.Asp165Asn Single submitter ⚠
- p.Asp173Asn Single submitter ⚠
- p.Asp173Val Single submitter ⚠
- p.Asp326Asn Single submitter ⚠
- p.Asp499Asn Single submitter ⚠
- p.Asp499Gly Single submitter ⚠
- p.Cys134Tyr Single submitter ⚠
- p.Cys219Arg Single submitter ⚠
- p.Cys219Tyr Single submitter ⚠
- p.Gln128Glu Single submitter ⚠
- p.Gln349His Single submitter ⚠
- p.Gln405His Single submitter ⚠
- p.Gln409Pro Single submitter ⚠
- p.Glu182Gln Single submitter ⚠
- p.Glu411Lys Single submitter ⚠
- p.Glu47Lys Single submitter ⚠
- p.Glu61Lys Single submitter ⚠
- p.Gly120Arg Single submitter ⚠
- p.Gly232Asp Single submitter ⚠
- p.Gly548Asp Single submitter ⚠
- p.Gly548Val Single submitter ⚠
- p.Gly66Arg Single submitter ⚠
- p.His279Gln Single submitter ⚠
- p.Ile294Met Single submitter ⚠
- p.Leu237Phe Single submitter ⚠
- p.Leu551Phe Single submitter ⚠
- p.Lys221Asn Single submitter ⚠
- p.Lys245Glu Single submitter ⚠
- p.Lys404Arg Single submitter ⚠
- p.Lys433Asn Single submitter ⚠
- p.Lys433Glu Single submitter ⚠
- p.Met216Thr Single submitter ⚠
- p.Met235Ile Single submitter ⚠
- p.Met235Leu Single submitter ⚠
- p.Met317Val Single submitter ⚠
- p.Met384Ile Single submitter ⚠
- p.Phe202Leu Single submitter ⚠
- p.Phe80Val Single submitter ⚠
- p.Pro185Ser Single submitter ⚠
- p.Pro319Ala Single submitter ⚠
- p.Pro319Thr Single submitter ⚠
- p.Pro435Thr Single submitter ⚠
- p.Pro470Leu Single submitter ⚠
- p.Pro64Ser Single submitter ⚠
- p.Ser115Asn Single submitter ⚠
- p.Ser247Thr Single submitter ⚠
- p.Ser291Arg Single submitter ⚠
- p.Ser297Leu Single submitter
- p.Ser53Cys Single submitter ⚠
- p.Thr192Ala Single submitter ⚠
- p.Thr285Met Single submitter ⚠
- p.Thr285Ser Single submitter ⚠
- p.Thr537Met Single submitter ⚠
- p.Trp178Arg Single submitter ⚠
- p.Trp93Arg Single submitter ⚠
- p.Tyr16Cys Single submitter ⚠
- p.Tyr256Cys Single submitter ⚠
- p.Tyr370Cys Single submitter ⚠
- p.Val246Ile Single submitter ⚠
- p.Val283Leu Single submitter ⚠
- p.Val283Met Single submitter ⚠
- p.Val339Met Single submitter ⚠
- p.Val398Ile Single submitter ⚠
- p.Val398Leu Single submitter ⚠
- p.Val398Phe Single submitter ⚠
- p.Val549Ala Single submitter ⚠
- p.Val90Met Single submitter ⚠